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Zynlonta (Generic Loncastuximab Tesirine-lpyl Injection)

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Why is this medication prescribed?

Zynlonta (loncastuximab tesirine) was a prescription medication used for the treatment of relapsed or refractory large B-cell lymphoma. Specifically, it was indicated for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, including DLBCL arising from low-grade lymphoma, who had received at least two prior systemic therapies.

How should this medicine be used?

Zynlonta is typically administered intravenously by a healthcare professional. The recommended dosage and schedule can depend on factors such as the patient’s weight, overall health, and response to previous treatments. The treatment regimen may involve multiple cycles, and each cycle may consist of one or more doses.

Here is a general overview of the administration process:

  • Administration by Healthcare Professional: Zynlonta is usually administered by a qualified healthcare professional, such as a nurse or doctor, in a healthcare facility.
  • Preparation of the Medication: The medication may need to be prepared and diluted before administration. This is typically done by the healthcare provider according to specific guidelines.
  • Intravenous Infusion: Zynlonta is often given as an intravenous (IV) infusion, meaning it is delivered directly into the bloodstream through a vein.
  • Monitoring: During and after the infusion, healthcare providers monitor the patient for any potential side effects or adverse reactions. This may include checking vital signs and conducting other assessments.

It’s crucial to attend all scheduled appointments and follow-up visits as recommended by your healthcare provider. If you have any questions or concerns about the use of Zynlonta, do not hesitate to discuss them with your healthcare team.

For the most accurate and current information, consult with your prescribing healthcare provider or refer to the official prescribing information provided by the drug manufacturer. They can provide you with personalized guidance based on your medical history and condition.

Other uses for this medicine

Zynlonta was specifically approved for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, including DLBCL arising from low-grade lymphoma, who had received at least two prior systemic therapies. The use of Zynlonta for other conditions or in populations other than those specified in the prescribing information would be considered off-label and should only be done under the guidance of a healthcare professional.

What special precautions should I follow?

When using Zynlonta or any other medication, it’s crucial to follow the prescribed treatment plan and adhere to any special precautions outlined by your healthcare provider. Here are some general considerations:

  • Patient Evaluation: Before starting Zynlonta, your healthcare provider will assess your overall health, medical history, and any pre-existing conditions. This evaluation helps determine if Zynlonta is a suitable treatment for you.
  • Monitoring: Regular monitoring is typically required during and after treatment with Zynlonta. This may include blood tests, imaging studies, and other assessments to monitor treatment response and detect any potential side effects.
  • Adverse Reactions: Zynlonta, like any medication, may be associated with side effects. It’s important to report any unusual or severe reactions to your healthcare provider promptly.
  • Contraindications: There may be certain contraindications or situations where Zynlonta should not be used. Your healthcare provider will consider your individual circumstances and medical history to determine if Zynlonta is appropriate for you.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it’s crucial to discuss this with your healthcare provider. They can provide guidance on the potential risks and benefits of Zynlonta in these situations.

Always consult with your healthcare provider for the most up-to-date and personalized information regarding the use of Zynlonta, including any special precautions based on your individual health status.

What special dietary instructions should I follow?

As of last update, there were no specific dietary instructions associated with Zynlonta. However, always consult your healthcare provider or pharmacist for any specific dietary considerations related to your treatment. They can provide guidance based on your individual health status and the latest information.

What should I do if I forget a dose?

If you miss a dose of Zynlonta, it’s important to contact your healthcare provider as soon as possible for guidance. They will provide instructions on how to proceed, which may involve rescheduling the missed dose or adjusting the treatment plan. Do not attempt to make up for a missed dose without consulting your healthcare provider, as they will consider the specific circumstances and your overall treatment plan.

What side effects can this medication cause?

Zynlonta (loncastuximab tesirine) can cause a range of side effects, and it’s important to note that individual responses to the medication can vary. The information provided here is based on the available data up to that point, and new information may have emerged since then. Always consult with your healthcare provider or refer to the latest prescribing information for the most up-to-date details. Common side effects and adverse reactions associated with Zynlonta can include:

  • Infusion-Related Reactions: This may include symptoms such as fever, chills, nausea, fatigue, headache, and low blood pressure. These reactions typically occur during or shortly after the infusion.
  • Hematologic Side Effects: Zynlonta can affect blood cell counts, leading to conditions such as neutropenia (low levels of neutrophils, a type of white blood cell), anemia, and thrombocytopenia (low platelet count). This may result in an increased risk of infections, fatigue, and easy bruising or bleeding.
  • Liver Enzyme Elevation: Zynlonta may cause an increase in liver enzymes, which can be detected through blood tests. Your healthcare provider will monitor liver function regularly during treatment.
  • Skin Reactions: Rash and itching are among the reported skin-related side effects.
  • Other Common Side Effects: Other common side effects may include fatigue, fever, cough, and difficulty breathing.
  • Serious Adverse Events: In some cases, serious and potentially life-threatening events can occur, including severe skin reactions, liver problems, and infusion-related reactions.

It’s important to report any side effects or unusual symptoms to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment plan if necessary.

This list is not exhaustive, and the occurrence and severity of side effects can vary from person to person. Before starting Zynlonta, your healthcare provider will discuss the potential risks and benefits with you, considering your individual health status and the specific characteristics of your condition. If you have been prescribed Zynlonta, it’s crucial to have open and regular communication with your healthcare team to ensure the most effective and safe management of your treatment.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zynlonta:


  • Temperature: Zynlonta is typically stored in a controlled environment. Follow the storage temperature recommendations provided by the manufacturer and your healthcare provider.
  • Refrigeration: Some medications, including certain intravenous drugs, may require refrigeration. Check the product label or packaging for specific instructions.


  • Dispose of Unused Medication: If you have unused Zynlonta or if it has expired, follow the disposal instructions provided by your healthcare provider or pharmacist.
  • Proper Disposal: Medications should not be disposed of in household trash or flushed down the toilet unless specifically instructed. Instead, consult with your healthcare provider or local pharmacy for proper disposal methods.

In case of emergency/overdose

  • Seek Medical Attention: In case of an overdose or emergency, seek immediate medical attention. Contact your local poison control center or emergency room.
  • Symptoms of Overdose: Symptoms of overdose may vary but could include severe infusion-related reactions, hematologic abnormalities, and other serious adverse events. Prompt medical attention is essential.

What other information should I know?

  • Follow Healthcare Provider’s Instructions: Always use Zomig Nasal Spray as directed by your healthcare provider. Do not exceed the recommended dosage.
  • Inform Healthcare Provider: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. This is important to avoid potential drug interactions.
  • Report Side Effects: Report any unusual or severe side effects to your healthcare provider promptly.
  • Allergies: If you are allergic to zolmitriptan or any components of Zomig Nasal Spray, inform your healthcare provider.
  • Medical Conditions: Inform your healthcare provider about any existing medical conditions, especially cardiovascular conditions, before using Zomig Nasal Spray.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Zomig Nasal Spray with your healthcare provider.
  • Regular Monitoring: Regularly monitor your response to the medication and discuss any concerns with your healthcare provider.
  • Driving and Operating Machinery: Zomig Nasal Spray may cause dizziness. Avoid driving or operating machinery until you know how the medication affects you.

Always consult your healthcare provider or pharmacist for specific and up-to-date information about the storage, disposal, and emergency procedures associated with Zomig Nasal Spray.

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