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Zyflo CR (Generic Zileuton)

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Why is this medication prescribed?

Zyflo CR (zileuton) is a prescription medication used in the treatment of asthma. It belongs to a class of drugs known as leukotriene synthesis inhibitors. Asthma is a chronic respiratory condition characterized by inflammation and constriction of the airways, leading to symptoms such as wheezing, shortness of breath, and coughing.

Zyflo CR is specifically indicated for the prophylaxis and chronic treatment of asthma in adults and children who are 12 years of age and older. It is not intended for use as a rescue medication to relieve acute asthma attacks.

How should this medicine be used?

Here’s how Zyflo CR is typically used:

  • Dosage: The recommended dosage of Zyflo CR is usually twice daily, within one hour after morning and evening meals. The exact dosage may vary based on the individual’s age, weight, and the severity of their asthma. It’s essential to follow the prescribed dosage provided by the healthcare professional.
  • Administration: Zyflo CR is an extended-release tablet, meaning it releases the medication slowly over time. It is important not to crush or chew the tablets, as this can affect the way the medication is released.
  • Consistency: It is crucial to take Zyflo CR regularly and consistently as prescribed by the healthcare provider, even if the individual’s asthma symptoms are under control. This helps in maintaining a steady level of the medication in the body.
  • Monitoring: Regular follow-up with the healthcare provider is essential to monitor the effectiveness of Zyflo CR and to make any necessary adjustments to the treatment plan.
  • Not for Acute Attacks: Zyflo CR should not be used to treat acute asthma attacks or sudden worsening of symptoms. For the relief of acute symptoms, a short-acting bronchodilator (rescue inhaler) is typically prescribed.
  • Side Effects and Precautions: Like any medication, Zyflo CR can have side effects, and individuals should be aware of potential adverse reactions. Common side effects may include liver enzyme elevations, headache, and gastrointestinal disturbances. It’s important to inform the healthcare provider about any pre-existing medical conditions or other medications being taken to ensure there are no potential interactions or contraindications.

As with any medication, individuals should follow their healthcare provider’s instructions precisely and inform them of any concerns or side effects experienced during the course of treatment. Only a qualified healthcare professional can determine if Zyflo CR is the appropriate treatment for an individual’s specific condition.

Other uses for this medicine

Zyflo CR (zileuton) is primarily indicated for the prophylaxis and chronic treatment of asthma in individuals aged 12 and older. It is a leukotriene synthesis inhibitor that helps to reduce inflammation in the airways. However, it’s important to note that new uses or indications for medications may emerge over time, and it’s advisable to consult with a healthcare professional or check more recent sources for any updates.

What special precautions should I follow?

Regarding special precautions for Zyflo CR, here are some general guidelines:

  • Allergies: Inform your healthcare provider about any allergies you may have, especially if you have had a previous reaction to zileuton or any other medications.
  • Liver Function: Zyflo CR may affect liver function, and it’s important to monitor liver enzymes regularly. Inform your healthcare provider about any pre-existing liver conditions or if you experience symptoms such as persistent nausea, fatigue, yellowing of the eyes or skin (jaundice), or dark urine.
  • Interactions with Other Medications: Make sure to provide a comprehensive list of all medications, including prescription and over-the-counter drugs, as well as any herbal supplements or vitamins, to your healthcare provider. Some medications may interact with Zyflo CR.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The potential risks and benefits of using Zyflo CR during pregnancy or breastfeeding should be discussed with your healthcare provider.
  • Monitoring and Regular Check-ups: Regular check-ups and monitoring of your asthma symptoms, as well as any potential side effects, are important. Follow-up appointments allow your healthcare provider to assess the effectiveness of the medication and make any necessary adjustments to your treatment plan.
  • Not for Acute Attacks: Zyflo CR is not intended for the treatment of acute asthma attacks. A short-acting bronchodilator (rescue inhaler) should be used for the relief of acute symptoms.
  • Adherence to Dosage Instructions: Take Zyflo CR exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your healthcare provider.
  • Side Effects: Be aware of potential side effects and report any unusual or severe reactions to your healthcare provider promptly.

It’s important to note that this information is based on general guidelines, and individual circumstances may vary. Always follow the specific guidance provided by your healthcare provider, and consult them if you have any questions or concerns about your medication.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Zyflo CR. However, it’s advisable to take Zyflo CR with food to enhance its absorption. Always follow your healthcare provider’s advice regarding the timing and conditions for taking your medication.

What should I do if I forget a dose?

If you forget to take a dose of Zyflo CR:

  • Take it as soon as you remember: If it’s close to the time of your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
  • Do not double up: Do not take a double dose to make up for a missed one. Taking too much medication at once can increase the risk of side effects.
  • Contact your healthcare provider: If you have concerns about missed doses or if you are unsure about what to do, contact your healthcare provider for guidance.

What side effects can this medication cause?

Zyflo CR (zileuton) can cause various side effects, and it’s important to be aware of them. Common side effects may include:

  • Headache: Headaches are a relatively common side effect of Zyflo CR.
  • Nausea or Upset Stomach: Some individuals may experience gastrointestinal symptoms such as nausea or stomach discomfort.
  • Liver Enzyme Elevations: Zyflo CR may affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function is usually recommended.
  • Insomnia: Difficulty sleeping or insomnia can occur in some individuals taking Zyflo CR.
  • Abnormal Liver Function Tests: This medication can cause changes in liver function tests, and these should be monitored regularly.
  • Flu-like Symptoms: Some people may experience symptoms resembling the flu, such as body aches and fatigue.
  • Elevated Blood Pressure: Zyflo CR has been associated with increases in blood pressure in some individuals.
  • Allergic Reactions: While rare, allergic reactions to Zyflo CR can occur. Seek medical attention immediately if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed here. Additionally, the severity and duration of side effects can vary among individuals. If you are prescribed Zyflo CR, your healthcare provider will monitor your response to the medication and adjust the treatment plan if necessary.

If you experience any concerning side effects or have questions about your medication, it’s crucial to contact your healthcare provider promptly. They can provide guidance on whether any side effects are expected or if adjustments to the treatment plan are needed. As with any medication, the benefits of Zyflo CR in managing asthma symptoms should be weighed against the potential risks, and your healthcare provider can help you make informed decisions about your treatment.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zyflo CR:

  • Storage:
    • Store Zyflo CR (zileuton) at room temperature, away from moisture and heat.
    • Keep the medication in its original container, and make sure the container is tightly closed.
    • Do not store Zyflo CR in the bathroom.
  • Disposal:
    • Follow any specific disposal instructions provided by your healthcare provider or pharmacist.
    • If no specific instructions are given, the U.S. Food and Drug Administration (FDA) recommends disposing of most medicines by mixing them with an unpalatable substance (such as kitty litter) in a sealed plastic bag and throwing it in the household trash.
    • Do not flush medications down the toilet unless instructed to do so, as this can potentially contaminate water sources.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention or contact your local poison control center immediately. Symptoms of an overdose may include:

  • Extreme drowsiness
  • Loss of consciousness
  • Seizures
  • Nausea or vomiting
  • Rapid breathing

What other information should I know?

  • Regular Follow-up: Attend regular follow-up appointments with your healthcare provider to monitor your response to Zyflo CR and make any necessary adjustments to your treatment plan.
  • Inform Healthcare Provider: Keep your healthcare provider informed about all medications, supplements, and herbal products you are taking, as well as any changes in your health.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Zyflo CR with your healthcare provider.
  • Not for Acute Attacks: Zyflo CR is not intended for the treatment of acute asthma attacks. Use a short-acting bronchodilator (rescue inhaler) for acute symptoms.
  • Medical Alert Bracelet: If applicable, wear a medical alert bracelet or carry a card indicating that you are taking Zyflo CR in case of emergency.
  • Follow Instructions: Follow your healthcare provider’s instructions regarding the timing, dosage, and administration of Zyflo CR.
  • Potential Drug Interactions: Be aware of potential drug interactions with Zyflo CR, and inform your healthcare provider about all medications you are taking.
  • Allergic Reactions: If you experience signs of an allergic reaction (such as rash, itching, swelling, severe dizziness, or difficulty breathing), seek medical attention immediately.

Always consult with your healthcare provider or pharmacist for the most up-to-date and personalized information regarding the storage, disposal, and use of Zyflo CR. The information provided here is general and may not cover all individual cases or considerations.

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