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Zinplava (Generic Bezlotoxumab Injection)

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Why is this medication prescribed?

Zinplava (bezlotoxumab) is a medication used in the prevention of Clostridium difficile infection (CDI) recurrence in adults who are at high risk for recurrence of this infection. Clostridium difficile is a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon.

Zinplava is not used to treat the initial infection with C. difficile but is rather prescribed to reduce the risk of recurrence in patients who have already had an episode of C. difficile infection and are at high risk for it to come back.

How should this medicine be used?

The standard dosing and administration information for Zinplava (bezlotoxumab) is as follows. However, please note that specific dosing and administration guidelines may vary, and it’s important to follow the instructions provided by the healthcare provider or the prescribing information for the most accurate and up-to-date information.

Dosage and Administration of Zinplava:

  • Dosing: The recommended dose of Zinplava is a single intravenous infusion of 10 mg/kg administered over 60 minutes.
  • Timing of Administration: Zinplava is administered as a one-time infusion in conjunction with standard-of-care antibiotic therapy for the treatment of the initial episode of C. difficile infection.
  • Co-administration with Antibiotics: Zinplava is typically administered during the same hospitalization as the course of antibiotics used to treat the initial C. difficile infection. It is not a treatment for the infection itself but is intended to prevent recurrence.
  • Reconstitution and Dilution: The specific reconstitution and dilution procedures should be followed according to the instructions provided in the prescribing information or by the healthcare provider.
  • Monitoring: Patients should be monitored during and after the infusion for any signs of adverse reactions.
  • Storage: Zinplava should be stored as directed by the manufacturer and healthcare provider. Proper storage conditions are essential to maintaining the effectiveness and stability of the medication.

It’s crucial to note that this information is based on knowledge, and there may have been updates or changes since then. Therefore, healthcare providers should always refer to the most recent prescribing information, guidelines, and protocols for Zinplava when prescribing and administering the medication. If you or someone you know is prescribed Zinplava, it’s important to follow the healthcare provider’s instructions and seek clarification on any questions or concerns.

Other uses for this medicine

Zinplava (bezlotoxumab) is primarily used for the prevention of recurrence of Clostridium difficile infection in adults who are at high risk. It is not indicated for the treatment of the initial infection or for other conditions.

What special precautions should I follow?

Special precautions and considerations for Zinplava include:

  • Patient Selection: Zinplava is typically prescribed to adults who are at high risk for recurrent C. difficile infection.
  • Not a Treatment for Active Infection: Zinplava is not used to treat the initial C. difficile infection. It is specifically for preventing recurrence in patients who have already had an episode.
  • Monitoring: Patients should be monitored for signs and symptoms of C. difficile infection and for adverse reactions during and after Zinplava administration.
  • Co-administration with Antibiotics: Zinplava does not interfere with the efficacy of the antibiotic used to treat the initial C. difficile infection. It is typically administered alongside standard-of-care antibiotics.
  • Side Effects: Common side effects may include nausea, fever, and headache. As with any medication, individuals may react differently, and serious allergic reactions are possible, although uncommon.
  • Pregnancy and Breastfeeding: The safety of Zinplava during pregnancy or breastfeeding has not been well studied, and the potential benefits should be weighed against potential risks.

It’s important to note that specific precautions and guidelines may vary, and healthcare providers will consider individual patient factors and medical history when prescribing medications. Since medical information and guidelines can change, it’s crucial to consult with a healthcare professional or refer to the most recent medical literature and prescribing information for the latest details on Zinplava and its precautions. If you have questions about this medication, it’s best to discuss them with your healthcare provider.

What special dietary instructions should I follow?

As of last update, Zinplava does not have specific dietary restrictions or interactions listed in the available information. However, always consult with your healthcare provider to ensure there are no specific dietary considerations or restrictions for your individual case.

What should I do if I forget a dose?

Since Zinplava is typically administered as a single infusion, the concept of a “missed dose” may not be applicable in the same way as it is for medications that are taken on a regular schedule. However, if you have any concerns or if there are changes to the planned administration, it’s crucial to communicate with your healthcare provider. They will provide guidance on how to proceed based on your specific situation.

What side effects can this medication cause?

Zinecard (dexrazoxane) is generally well-tolerated, but like any medication, it can cause side effects. Not everyone will experience these side effects, and some individuals may experience them to varying degrees. Common side effects of Zinecard include:

  • Nausea and Vomiting: Gastrointestinal symptoms such as nausea and vomiting are relatively common. Taking the medication with food may help alleviate these symptoms.
  • Low Blood Pressure: Zinecard can cause a temporary drop in blood pressure, leading to dizziness or lightheadedness. It’s important to get up slowly from a sitting or lying position to minimize the risk of dizziness.
  • Injection Site Reactions: Some individuals may experience pain, redness, or swelling at the site where Zinecard is injected.

Less common and more serious side effects can also occur. If you experience any of the following, it’s important to seek medical attention promptly:

  • Allergic Reactions: Allergic reactions to Zinecard are rare but can be serious. Seek medical attention if you develop symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
  • Blood Disorders: Zinecard can affect blood cell counts. Your healthcare provider may monitor your blood counts during treatment.
  • Liver Problems: In rare cases, Zinecard may cause liver problems. Symptoms may include yellowing of the eyes or skin (jaundice), dark urine, or persistent nausea.
  • Fever or Infection: Zinecard may suppress the bone marrow’s ability to produce blood cells, which can increase the risk of infection. Contact your healthcare provider if you experience signs of infection, such as fever or persistent sore throat.

It’s important to note that the above list is not exhaustive, and individual responses to medication can vary. Always inform your healthcare provider if you experience any unusual or bothersome symptoms during treatment with Zinecard. Additionally, discuss any concerns you may have about potential side effects with your healthcare team before starting treatment. They can provide personalized information based on your medical history and specific circumstances.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zinecard:


  • Store Zinplava as directed by the healthcare provider or pharmacist.
  • Follow the manufacturer’s recommendations for temperature and storage conditions.
  • Keep Zinplava out of the reach of children.


  • Dispose of any unused or expired Zinplava as directed by your healthcare provider or pharmacist.
  • Do not flush medications down the toilet unless specifically instructed to do so. Proper disposal helps prevent environmental contamination.

In case of emergency/overdose

  • In case of emergency or suspected overdose, seek medical attention or contact your local poison control center immediately.
  • Be prepared to provide information about the medication, the amount taken, and the time of ingestion.

What other information should I know?

  • Inform your healthcare provider of all medications you are taking, including prescription, over-the-counter, and herbal supplements.
  • Keep a record of your medical history, including allergies and previous reactions to medications.
  • Attend follow-up appointments as scheduled by your healthcare provider.
  • Report any new or worsening symptoms to your healthcare provider promptly.

Always consult with your healthcare provider or pharmacist for the most accurate and up-to-date information regarding the storage, disposal, and emergency procedures associated with Zinplava. Medication guidelines and recommendations may change, so it’s essential to stay informed and follow the advice of healthcare professionals.

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