PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Zetonna (Generic Ciclesonide Nasal Spray)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Zetonna (ciclesonide) is a prescription nasal spray that is primarily used to treat symptoms of allergic rhinitis, including nasal congestion, sneezing, and runny nose. Allergic rhinitis is an inflammatory condition of the nasal passages that occurs in response to exposure to allergens such as pollen, dust mites, pet dander, or mold.

Ciclesonide, the active ingredient in Zetonna, is a corticosteroid. Corticosteroids work by reducing inflammation and suppressing the immune response, which helps alleviate symptoms associated with allergic reactions.

How should this medicine be used?

Here are general guidelines on how Zetonna should be used:

  • Dosage: The usual recommended dosage for Zetonna is typically one or two sprays in each nostril once daily.
  • Administration: Shake the nasal spray well before each use. Hold the spray bottle upright and close to your nostril. Breathe out gently, then insert the nozzle into your nostril while keeping your head upright. Close the other nostril with your finger and, while inhaling through your nose, press down on the pump to release the spray. Breathe out through your mouth.
  • Avoiding Contact with Eyes: Be careful to avoid spraying the medication into your eyes. If accidental contact with the eyes occurs, rinse your eyes thoroughly with water.
  • Cleaning the Spray Nozzle: To prevent blockage, clean the spray nozzle regularly. Instructions for cleaning can usually be found in the medication’s packaging or provided by your healthcare provider.
  • Consistency: It’s essential to use Zetonna consistently, even if you feel better. The full benefit of the medication may take several days to a couple of weeks to be realized.
  • Follow Healthcare Provider’s Instructions: Always follow your healthcare provider’s instructions and the information provided with the medication. Do not exceed the recommended dosage unless directed by your healthcare provider.

It’s important to note that these are general guidelines, and individual circumstances may vary. Always consult with your healthcare provider for personalized advice and to ensure that Zetonna is the right medication for your specific condition. Additionally, inform your healthcare provider about any other medications or health conditions you have to avoid potential interactions or complications.

Other uses for this medicine

Zetonna (ciclesonide) is primarily indicated for the treatment of allergic rhinitis. However, it’s essential to note that medications can sometimes be prescribed for off-label uses based on a healthcare provider’s judgment. Off-label use refers to using a medication for a purpose other than what it was initially approved for. If your healthcare provider prescribes Zetonna for a specific condition, it’s crucial to follow their guidance and discuss any concerns you may have.

What special precautions should I follow?

As for special precautions when using Zetonna, here are some key considerations:

  • Allergies: Inform your healthcare provider if you are allergic to ciclesonide or any other corticosteroids. Also, disclose any other allergies you may have.
  • Medical History: Provide your healthcare provider with a comprehensive medical history, including any previous or current medical conditions. Be sure to mention if you have a history of nasal problems, glaucoma, or other eye conditions.
  • Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss the potential risks and benefits of using Zetonna with your healthcare provider. It’s essential to weigh the potential benefits against any possible risks to the fetus or infant.
  • Infections: Corticosteroids like ciclesonide can suppress the immune system. Inform your healthcare provider if you have had recent or ongoing infections, as this may affect the decision to prescribe Zetonna.
  • Drug Interactions: Make sure to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Certain medications may interact with Zetonna.
  • Eye Precautions: While Zetonna is a nasal spray, it’s important to avoid getting the medication into your eyes. If accidental contact occurs, rinse your eyes with water.
  • Children: Zetonna is not typically recommended for children under the age of 12. If your child has allergies or nasal congestion, discuss appropriate treatment options with a pediatrician.
  • Consistent Use: Use Zetonna regularly as prescribed, even if you feel better. Abruptly stopping corticosteroid medications can lead to a rebound effect, where symptoms may worsen.

Always follow your healthcare provider’s instructions and ask any questions you may have about the medication. If you experience any unexpected or severe side effects, contact your healthcare provider promptly. These precautions are general in nature, and specific recommendations may vary based on individual health circumstances.

What special dietary instructions should I follow?

There are typically no specific dietary restrictions associated with Zetonna. However, it’s crucial to maintain a healthy and balanced diet to support overall well-being.

What should I do if I forget a dose?

If you forget to take a dose of Zetonna, follow these general guidelines:

  • As Soon As Possible:
    • Take the missed dose as soon as you remember.
  • Skip If Close to Next Dose:
    • If it’s almost time for your next scheduled dose, skip the missed one.
  • Do Not Double Dose:
    • Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Zetonna (ciclesonide) nasal spray, like any medication, may cause side effects. It’s important to be aware of potential side effects and to contact your healthcare provider if you experience any that are concerning or persistent. Common side effects of Zetonna include:

  • Nasal Irritation: This may include irritation or a burning sensation in the nose.
  • Nasal Dryness: Some individuals may experience dryness in the nasal passages.
  • Headache: Headaches are a common side effect reported by some users.
  • Throat Irritation: Zetonna may cause irritation in the throat.
  • Nosebleeds: In some cases, nasal corticosteroids can lead to nosebleeds.
  • Coughing: Coughing is another reported side effect.
  • Increased Risk of Infections: Corticosteroids can suppress the immune system, potentially increasing the risk of infections, especially if used at high doses for prolonged periods.
  • Adrenal Suppression: Prolonged use of high doses may lead to adrenal suppression, which is a decrease in the function of the adrenal glands.
  • Glaucoma and Cataracts: Long-term use of corticosteroids, particularly if used at high doses, may be associated with an increased risk of developing glaucoma or cataracts.
  • Systemic Effects: While Zetonna is a nasal corticosteroid and is designed to have minimal systemic effects, it’s important to be aware of the possibility of systemic absorption, especially at higher doses.

It’s crucial to follow your healthcare provider’s instructions regarding the use of Zetonna and to report any side effects promptly. Additionally, inform your healthcare provider about any other medications you are taking to avoid potential drug interactions.

If you experience severe or persistent side effects, or if you have concerns about the medication, contact your healthcare provider. They can provide guidance on whether adjustments to the treatment plan are needed or if an alternative medication may be more suitable for you.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zetonna:


  • Room Temperature: Store Zetonna at room temperature, away from moisture and heat.
  • Avoid Freezing: Do not allow the medication to freeze.
  • Protect from Light: Keep the nasal spray container away from direct light.
  • Keep Out of Reach of Children: Store Zetonna in a location that is not accessible to children or pets.


  • Follow Local Guidelines: Dispose of unused or expired medications according to local regulations and guidelines.
  • Do Not Flush: Do not flush Zetonna down the toilet or pour it into a drain unless instructed to do so.
  • Consult Pharmacist: If you are unsure about how to properly dispose of Zetonna, consult your pharmacist or healthcare provider.

In case of emergency/overdose

  • Seek Medical Attention: In case of an overdose or if someone accidentally ingests Zetonna, seek emergency medical attention or contact a poison control center immediately.
  • Symptoms of Overdose: Symptoms of overdose may include severe dizziness, fainting, or difficulty breathing.

What other information should I know

  • Regular Follow-ups: Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness of the medication and to discuss any concerns or potential side effects.
  • Inform Healthcare Provider: Keep your healthcare provider informed about all medications you are taking, including over-the-counter drugs and supplements.
  • Adherence to Instructions: Follow the instructions provided by your healthcare provider regarding the proper use of Zetonna, including dosage and administration.
  • Monitoring for Side Effects: Be vigilant for any potential side effects, and report them to your healthcare provider if they occur.
  • Inform Other Healthcare Providers: Make sure to inform other healthcare providers, including dentists and specialists, that you are using Zetonna.
  • Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the use of Zetonna with your healthcare provider to assess the potential risks and benefits.

Always follow the specific guidance provided by your healthcare provider and the information included with the medication. If you have any questions or concerns, don’t hesitate to reach out to your healthcare provider or pharmacist for clarification and advice.

Copyright © 2023