WARNING

Zestoretic is a combination medication that contains two active ingredients: lisinopril (an angiotensin-converting enzyme, or ACE, inhibitor) and hydrochlorothiazide (a diuretic). While Zestoretic can be effective in treating conditions such as hypertension, it also carries some risks and potential side effects. Here is a brief overview of the risks associated with taking Zestoretic:

• Hypotension (Low Blood Pressure): Zestoretic can cause a significant drop in blood pressure, especially when starting the medication or increasing the dose. This may result in symptoms such as dizziness, lightheadedness, and fainting.
• Electrolyte Imbalance: The hydrochlorothiazide component in Zestoretic is a diuretic that can lead to electrolyte imbalances, including low levels of potassium. This can result in muscle weakness, irregular heartbeats, and other complications.
• Kidney Impairment: ACE inhibitors like lisinopril can affect kidney function, particularly in individuals with pre-existing kidney conditions. Regular monitoring of kidney function is usually recommended.
• Allergic Reactions: Some individuals may experience allergic reactions to Zestoretic, which can manifest as rash, itching, swelling, severe dizziness, or difficulty breathing. Immediate medical attention is necessary if allergic reactions occur.
• Angioedema: This is a rare but serious side effect associated with ACE inhibitors like lisinopril. Angioedema involves the swelling of deeper layers of the skin, often around the eyes and lips, and can be life-threatening if it affects the airways.
• Photosensitivity: Zestoretic may increase sensitivity to sunlight, making individuals more prone to sunburn. It’s advisable to use sunscreen and take other precautions when exposed to sunlight.
• Worsening of Diabetes: Zestoretic may affect blood sugar levels, and individuals with diabetes should monitor their blood sugar closely. Adjustments to diabetes medications may be necessary.
• Gout: Hydrochlorothiazide, being a diuretic, can increase the levels of uric acid in the blood and potentially trigger gout attacks in susceptible individuals.

It’s crucial for individuals taking Zestoretic to be aware of these potential risks and side effects. Regular monitoring by a healthcare professional is essential to assess blood pressure, kidney function, and overall health. Before starting Zestoretic, it’s important to inform your healthcare provider about any existing medical conditions, medications, or allergies, and to follow their instructions closely. If you experience any concerning side effects, seek prompt medical attention. Never stop or adjust your medication without consulting your healthcare provider.

Why is this medication prescribed?

Zestoretic is a prescription medication that combines two active ingredients: lisinopril and hydrochlorothiazide. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide is a thiazide diuretic. This combination is used to treat high blood pressure (hypertension).

• Lisinopril (ACE inhibitor): It works by relaxing blood vessels, which helps reduce blood pressure and makes it easier for the heart to pump blood.
• Hydrochlorothiazide (thiazide diuretic): It increases urine production, leading to the removal of excess salt and water from the body. This helps to lower blood pressure.

The combination of these two medications in Zestoretic helps to control blood pressure more effectively than using either drug alone.

How should this medicine be used?

Here are general guidelines for the use of Zestoretic:

• Dosage: The dosage of Zestoretic can vary depending on the specific condition being treated and the patient’s response to the medication. It is important to take the medication exactly as prescribed by the healthcare provider.
• Administration: Zestoretic is typically taken orally, with or without food. It is important to take the medication at the same time each day to maintain a consistent level in the bloodstream.
• Follow your doctor’s instructions: It’s crucial to follow your healthcare provider’s instructions regarding the dosage and duration of treatment. Do not alter the dosage or stop taking the medication without consulting your doctor.
• Regular monitoring: Your doctor may monitor your blood pressure and kidney function regularly while you are taking Zestoretic. This is to ensure that the medication is effective and not causing any adverse effects.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses to make up for a missed one.
• Precautions: Inform your healthcare provider about any other medications, supplements, or medical conditions you have, as they may interact with Zestoretic.

Always consult with your healthcare provider for personalized advice regarding your specific medical condition and the use of Zestoretic. This information is general and should not replace professional medical advice.

Other uses for this medicine

• Heart Failure: In some cases, healthcare providers may prescribe Zestoretic for the management of heart failure, especially when high blood pressure is a contributing factor.
• Kidney Protection: Zestoretic might be used to protect the kidneys in certain conditions, such as in individuals with diabetes who have both high blood pressure and protein in their urine.
• Prevention of Stroke: Zestoretic may be considered for stroke prevention in certain individuals at high risk.

What special precautions should I follow?

Special precautions and considerations for Zestoretic may include the following:

• Pregnancy and Breastfeeding: Zestoretic is generally not recommended during pregnancy, especially in the second and third trimesters, as it can harm the developing fetus. It may also pass into breast milk, so breastfeeding is usually not recommended while taking Zestoretic.
• Allergies: Inform your healthcare provider about any known allergies to ACE inhibitors or thiazide diuretics, as Zestoretic contains both.
• Kidney Function: Zestoretic can affect kidney function. Regular monitoring of kidney function, including blood tests, is usually recommended.
• Electrolyte Imbalance: Zestoretic can lead to changes in electrolyte levels, particularly potassium. Periodic monitoring of electrolytes is often advised.
• Dehydration: Because of its diuretic effect, Zestoretic may lead to dehydration. It’s essential to stay adequately hydrated, especially in hot weather or during vigorous exercise.
• Blood Pressure Drops: The combination of lisinopril and hydrochlorothiazide in Zestoretic can cause a significant drop in blood pressure, especially when starting the medication or increasing the dose. This may result in dizziness or fainting.
• Interaction with Other Medications: Zestoretic may interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), potassium supplements, and certain antidiabetic drugs. Inform your doctor about all medications you are taking.

Always follow your healthcare provider’s instructions and attend regular follow-up appointments to monitor your response to the medication and address any concerns or side effects. Do not adjust your dosage or stop taking the medication without consulting your healthcare provider. Individual responses to medications can vary, and your healthcare provider will tailor the treatment plan to your specific needs.

What special dietary instructions should I follow?

• Salt Intake: Zestoretic is used to control high blood pressure, and reducing salt intake can enhance its effectiveness. Follow your doctor’s advice on a low-sodium diet.
• Potassium-Rich Foods: Since Zestoretic can affect potassium levels, your doctor may recommend monitoring your potassium intake. Foods rich in potassium include bananas, oranges, tomatoes, and potatoes.
• Fluid Intake: Stay adequately hydrated, especially if you are experiencing excessive fluid loss due to diuretic effects.

What should I do if I forget a dose?

• Take it as Soon as Possible: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
• Do Not Double Up: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can lead to increased side effects and complications.
• Consult Your Doctor: If you are unsure about what to do or if you have missed multiple doses, consult your healthcare provider for guidance.

What side effects can this medication cause?

Zestoretic, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed. If you are prescribed Zestoretic, your healthcare provider will monitor you for potential side effects. Common side effects and less common, but more serious side effects of Zestoretic include:

Common Side Effects:

• Dizziness or Lightheadedness: Zestoretic can cause a drop in blood pressure, leading to dizziness or lightheadedness, especially when standing up quickly.
• Cough: An ACE inhibitor component in Zestoretic, lisinopril, may cause a persistent cough in some individuals. If this occurs, inform your healthcare provider.
• Fatigue: Some people may experience fatigue or weakness while taking Zestoretic.
• Headache: Headaches are a common side effect of many medications, including Zestoretic.

Less Common but Serious Side Effects:

• Hypotension (Low Blood Pressure): Zestoretic can cause a significant drop in blood pressure, leading to symptoms like fainting. This is more likely to occur at the beginning of treatment or when the dosage is increased.
• Kidney Problems: Zestoretic can affect kidney function, and in rare cases, it may lead to kidney problems. Regular monitoring of kidney function is typically recommended.
• High Blood Potassium Levels: Zestoretic can lead to increased levels of potassium in the blood (hyperkalemia), which can be serious. Symptoms of high potassium may include weakness, irregular heartbeat, or tingling sensations.
• Allergic Reactions: Some individuals may experience allergic reactions, including swelling of the face, lips, or tongue, and difficulty breathing.
• Angioedema: This is a rare but serious side effect involving swelling of deeper layers of the skin, often around the eyes and lips.
• Blood Disorders: In rare cases, Zestoretic may affect blood cell counts, leading to conditions like agranulocytosis or thrombocytopenia.

If you experience any severe or persistent side effects, contact your healthcare provider immediately. Do not stop taking Zestoretic without consulting your doctor, as abrupt discontinuation can have adverse effects.

It’s crucial to communicate openly with your healthcare provider about any side effects or concerns you may have. They can help determine whether the benefits of the medication outweigh the potential risks and may adjust the treatment plan accordingly. This information is not exhaustive, and individual responses to medications can vary, so always consult with your healthcare provider for personalized advice.

What should I know about storage and disposal of this medication?

Storage:

• Store Zestoretic at room temperature, away from moisture and heat.
• Keep the medication in its original packaging to protect it from light.
• Avoid storing it in the bathroom, as moisture can affect the medication.

Disposal:

• Dispose of Zestoretic as directed by your healthcare provider or pharmacist.
• Do not flush medications down the toilet unless instructed to do so.
• Check with your local pharmacy or healthcare provider for information on safe disposal methods for unused or expired medications.

In case of emergency/overdose

In case of an emergency or overdose, seek medical attention immediately. Symptoms of overdose may include extreme dizziness, weakness, or fainting.

What other information should I know

• Regular Monitoring: Your healthcare provider may conduct regular check-ups and monitor your blood pressure, kidney function, and electrolyte levels while you are taking Zestoretic.
• Lab Tests: Regular blood tests may be required to check potassium levels and kidney function.
• Informing Healthcare Providers: Make sure to inform all healthcare providers (doctors, dentists, emergency room staff) about your use of Zestoretic.
• Avoiding Alcohol: Limit alcohol consumption while taking Zestoretic, as alcohol can potentiate the blood pressure-lowering effects of the medication.
• Dehydration and Sweating: Inform your healthcare provider if you experience excessive sweating, dehydration, or vomiting, as these can affect electrolyte balance.
• Medical Alert Bracelet: If you are at risk of severe allergic reactions or have a history of angioedema, your healthcare provider may recommend wearing a medical alert bracelet.
• Informing About Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Zestoretic may interact with other drugs.
• Avoiding Salt Substitutes: If your healthcare provider advises you to limit salt intake, avoid using potassium-containing salt substitutes without their approval.
• Pregnancy and Planning: If you are planning to become pregnant or suspect you are pregnant, inform your healthcare provider, as Zestoretic may not be suitable during pregnancy.
• Allergic Reactions: Be aware of signs of allergic reactions, such as swelling of the face, lips, or tongue, and difficulty breathing. Seek immediate medical attention if these occur.

Always follow your healthcare provider’s advice and instructions carefully. This information provides general guidelines and is not a substitute for professional medical advice. Individual responses to medications can vary, so consult with your healthcare provider for personalized information based on your health condition.