Why is this medication prescribed?

Zerbaxa is a prescription medication that is a combination of two active ingredients: ceftolozane and tazobactam. It is used for the treatment of various bacterial infections in adults. Ceftolozane is a cephalosporin antibiotic, and tazobactam is a beta-lactamase inhibitor. The combination of these two agents in Zerbaxa helps to broaden the spectrum of antibacterial activity.

Zerbaxa is specifically indicated for the treatment of complicated intra-abdominal infections (cIAI) and complicated urinary tract infections (cUTI), including pyelonephritis. These infections can be caused by susceptible Gram-negative bacteria.

How should this medicine be used?

Zerbaxa (ceftolozane/tazobactam) is a prescription medication, and its use should be directed by a healthcare professional. The dosage and administration instructions may vary based on the specific infection being treated, the severity of the infection, and individual patient factors. Always follow your healthcare provider’s instructions and read the medication guide provided by the pharmacist. Below are general guidelines, but they may not be suitable for every case:

• Dosage and Frequency: Zerbaxa is typically administered intravenously (IV) over a specific period. The dosage and frequency depend on the type and severity of the infection. Your healthcare provider will determine the appropriate dose for your specific situation.
• Administration: Zerbaxa is usually given by a healthcare professional in a hospital or clinical setting. It is infused into a vein over a set amount of time.
• Duration of Treatment: The duration of treatment with Zerbaxa will be determined by your healthcare provider based on the type of infection and how well you respond to the medication. It’s important to complete the full course of treatment even if symptoms improve before the medication is finished.
• Follow-up: Your healthcare provider may conduct periodic assessments to monitor your response to the medication. If there are any concerns or if your condition changes, adjustments to the treatment plan may be made.
• Precautions: Inform your healthcare provider about any allergies, medical conditions, or medications you are currently taking. This includes over-the-counter drugs, supplements, and herbal products.
• Side Effects: Be aware of potential side effects and contact your healthcare provider if you experience any unusual or severe reactions.
• Missed Dose: If you miss a dose, it’s important to contact your healthcare provider for guidance. Do not double up on doses unless specifically instructed to do so.
• Storage: If you are given any Zerbaxa to take home, follow proper storage instructions. Some medications may require refrigeration, while others may be stored at room temperature.

Always consult with your healthcare provider or pharmacist if you have any questions or concerns about the use of Zerbaxa. This information is a general guide and may not cover all situations. Individual circumstances and medical conditions can vary, so personalized advice from a healthcare professional is crucial.

Other uses for this medicine

Zerbaxa is primarily prescribed for the specified indications mentioned above. Any use of this medication for other conditions would be off-label and should be discussed thoroughly with a healthcare provider. Off-label use refers to the use of a medication for purposes not approved by regulatory authorities.

What special precautions should I follow?

Before using Zerbaxa, it’s crucial to inform your healthcare provider of your complete medical history, including any allergies, existing medical conditions, and medications you are currently taking. Here are some special precautions associated with Zerbaxa:

• Allergies: If you are allergic to any cephalosporin antibiotics, beta-lactam antibiotics, or any other components of Zerbaxa, inform your healthcare provider. Allergic reactions can range from mild to severe and may require immediate medical attention.
• Kidney Function: Zerbaxa is eliminated through the kidneys. If you have impaired kidney function, your healthcare provider may need to adjust the dosage. It’s essential to disclose any pre-existing kidney conditions.
• Pregnancy and Breastfeeding: The safety of Zerbaxa during pregnancy and breastfeeding is not well established. It should be used during pregnancy only if the potential benefits justify the potential risks. It’s crucial to discuss with your healthcare provider if you are pregnant or planning to become pregnant or if you are breastfeeding.
• Clostridium difficile Infection: Antibiotic use, including Zerbaxa, may be associated with the development of Clostridium difficile-associated diarrhea. If you experience persistent diarrhea, inform your healthcare provider.
• Seizure Risk: Like other beta-lactam antibiotics, Zerbaxa may increase the risk of seizures. Inform your healthcare provider if you have a history of seizures or other neurologic conditions.
• Drug Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking. Some drugs may interact with Zerbaxa, potentially affecting its efficacy or increasing the risk of side effects.

Always follow your healthcare provider’s instructions and guidance regarding the use of Zerbaxa. If you have specific concerns or questions about this medication, discuss them with your healthcare provider or pharmacist for personalized advice.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with Zerbaxa. However, it’s essential to maintain a well-balanced diet and stay hydrated, especially if you are dealing with an infection. If you have specific dietary concerns or restrictions, discuss them with your healthcare provider.

What should I do if I forget a dose?

If you forget a dose of Zerbaxa, it’s crucial to contact your healthcare provider for guidance. They will provide specific instructions based on the circumstances. In general:

• In a Hospital Setting: If you are receiving Zerbaxa in a hospital or clinic, the healthcare professionals administering the medication will manage the schedule. If a dose is missed, they will take appropriate action.
• At Home: If you are prescribed Zerbaxa to take at home and you miss a dose, contact your healthcare provider immediately. Do not double up on doses unless explicitly instructed to do so.

What side effects can this medication cause?

Zerbaxa (ceftolozane/tazobactam) may cause side effects, and it’s important to be aware of them and promptly report any unusual or severe reactions to your healthcare provider. Common side effects and potential adverse reactions associated with Zerbaxa include:

• Diarrhea: Like many antibiotics, Zerbaxa can disrupt the normal balance of bacteria in the digestive system, leading to diarrhea. If diarrhea is severe or persistent, inform your healthcare provider.
• Nausea and Vomiting: Some individuals may experience nausea or vomiting during Zerbaxa treatment.
• Headache: Headache is a relatively common side effect of Zerbaxa.
• Fever: Fever may occur as a response to infection or as a side effect of the medication.
• Elevated Liver Enzymes: Zerbaxa may cause changes in liver function tests. Your healthcare provider may monitor your liver function during treatment.
• Allergic Reactions: Allergic reactions to Zerbaxa can occur, ranging from mild skin reactions to severe reactions such as anaphylaxis. Seek immediate medical attention if you experience symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing.
• Clostridium difficile Infection: Use of Zerbaxa may be associated with the development of Clostridium difficile-associated diarrhea, a serious condition. Inform your healthcare provider if you experience persistent or severe diarrhea.
• Seizures: Like other beta-lactam antibiotics, Zerbaxa may increase the risk of seizures, especially in individuals with a history of seizures.

It’s important to note that this is not an exhaustive list, and individual reactions can vary. Always consult the prescribing healthcare provider or pharmacist for the most current information regarding potential side effects and what to watch for during Zerbaxa treatment.

If you experience severe or persistent side effects, or if you have concerns about your medication, contact your healthcare provider promptly. In case of a medical emergency, such as difficulty breathing or a severe allergic reaction, seek immediate medical attention or call emergency services.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zerbaxa:

• Storage: Zerbaxa is typically administered in a healthcare setting, and the storage is managed by healthcare professionals. If you are provided with Zerbaxa to take home, follow any specific storage instructions provided by your healthcare provider or pharmacist. Some medications may require refrigeration, while others may be stored at room temperature. Keep it out of reach of children.
• Disposal: If you have any leftover Zerbaxa or if it has expired, it’s important to dispose of it properly. Do not flush medications down the toilet or throw them in the trash. Check with your local pharmacy or healthcare facility for guidance on how to dispose of medications safely.

In case of emergency/overdose

In case of an emergency or suspected overdose, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention immediately. Overdose symptoms may include severe nausea, vomiting, or seizures. Provide as much information as possible about the medication taken, including the name (Zerbaxa), dosage, and the time it was taken.

What other information should I know

• Follow Instructions: Take Zerbaxa exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking it without consulting your healthcare provider.
• Complete the Course: Complete the full course of Zerbaxa, even if your symptoms improve before the medication is finished. Stopping antibiotics prematurely may result in the incomplete elimination of bacteria and contribute to antibiotic resistance.
• Allergic Reactions: Be vigilant for signs of allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience these symptoms.
• Inform Healthcare Provider: Inform your healthcare provider about all medications, supplements, and herbal products you are taking. This includes over-the-counter drugs.
• Regular Check-ups: Attend any follow-up appointments or laboratory tests recommended by your healthcare provider to monitor your response to the medication.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The safety of Zerbaxa during pregnancy and breastfeeding is not well established.
• Driving and Activities: Zerbaxa may cause dizziness. Avoid driving or engaging in activities requiring alertness until you know how the medication affects you.

This information is a general guide, and it’s important to consult with your healthcare provider or pharmacist for personalized advice based on your specific medical condition and needs.