PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Zaroxolyn (Generic Metolazone)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Zaroxolyn is a brand name for the medication metolazone, which belongs to a class of drugs known as diuretics or water pills. It is typically prescribed to treat conditions associated with fluid retention, such as edema (swelling) due to congestive heart failure, kidney problems, or liver cirrhosis.

The primary function of Zaroxolyn is to increase urine production by the kidneys, thereby helping the body eliminate excess water and salt. This can be beneficial in reducing edema and managing conditions where fluid buildup is a concern.

How should this medicine be used?

Dosage and usage instructions for Zaroxolyn may vary depending on the specific medical condition being treated and individual patient factors. It’s crucial to follow the doctor’s prescription and instructions carefully. Here are some general guidelines:

  • Dosage: The typical starting dose of Zaroxolyn can vary, but it’s usually taken once daily in the morning. The dosage may be adjusted by the healthcare provider based on the individual’s response to the medication.
  • Administration: Zaroxolyn is usually taken orally with or without food. It’s essential to take the medication consistently at the same time each day.
  • Monitoring: Regular medical check-ups and laboratory tests may be necessary to monitor the effectiveness of the medication and assess electrolyte levels (such as potassium) in the blood.
  • Fluid and Electrolyte Balance: While taking Zaroxolyn, it’s important to maintain a proper balance of fluids and electrolytes. Changes in diet, fluid intake, or the use of other medications can impact this balance.
  • Missed Dose: If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule should be resumed.

It’s crucial to inform the prescribing healthcare provider about any other medications, supplements, or medical conditions the individual may have, as interactions and contraindications can occur. Additionally, healthcare providers should be informed of any side effects or adverse reactions experienced while taking Zaroxolyn.

Patients should not adjust the dosage or stop taking Zaroxolyn without consulting their healthcare provider, as sudden changes can have adverse effects. As with any medication, the benefits and risks should be discussed with the prescribing healthcare professional.

Other uses for this medicine

In addition to treating conditions associated with fluid retention, Zaroxolyn (metolazone) may be used in the management of high blood pressure (hypertension). The medication’s diuretic effect helps lower blood pressure by reducing the volume of fluid in the blood vessels. However, its use for hypertension is often considered after other first-line antihypertensive medications have been tried.

What special precautions should I follow?

Special precautions should be taken when using Zaroxolyn, and it’s important to follow your healthcare provider’s guidance. Here are some general precautions to be aware of:

  • Medical History: Before taking Zaroxolyn, inform your healthcare provider about your complete medical history, especially if you have a history of kidney problems, liver disease, diabetes, gout, electrolyte imbalances, or if you are allergic to sulfa drugs.
  • Allergies: If you are allergic to sulfa drugs, it’s essential to let your healthcare provider know, as Zaroxolyn belongs to the thiazide-like diuretics, and some individuals who are allergic to sulfa drugs may also have a reaction to these medications.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Zaroxolyn during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with the healthcare provider.
  • Electrolyte Imbalance: Zaroxolyn can affect electrolyte levels, particularly potassium. Regular monitoring of electrolytes, especially potassium, is often recommended. Changes in diet or the use of other medications that affect electrolytes should be discussed with your healthcare provider.
  • Dehydration: Diuretics like Zaroxolyn can lead to increased urine production and potentially dehydration. It’s important to stay adequately hydrated and consult your healthcare provider if you experience symptoms of dehydration, such as excessive thirst, dry mouth, weakness, or dizziness.
  • Blood Pressure Monitoring: Regular monitoring of blood pressure is essential, especially when initiating or adjusting the dosage of Zaroxolyn.
  • Interactions with Other Medications: Inform your healthcare provider about all the medications, supplements, and over-the-counter drugs you are taking, as they may interact with Zaroxolyn.
  • Dizziness: Zaroxolyn may cause dizziness, especially when standing up quickly. Use caution when performing tasks that require alertness, such as driving, until you know how the medication affects you.

Always take Zaroxolyn exactly as prescribed by your healthcare provider, and do not adjust the dosage or stop taking it without consulting them. If you experience any side effects or have concerns about the medication, contact your healthcare provider promptly.

What special dietary instructions should I follow?

  • Potassium-Rich Foods: Be mindful of potassium-rich foods. Excessive intake may impact potassium levels. Foods high in potassium include bananas, oranges, potatoes, tomatoes, spinach, and certain nuts.
  • Salt Intake: Your healthcare provider may recommend a specific level of sodium (salt) intake.
  • Fluid Intake: Ensure adequate fluid intake, unless otherwise directed by your healthcare provider.

What should I do if I forget a dose?

Regarding a missed dose of Zarontin:

  • If You Forget a Dose: Take the missed dose as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
  • Do Not Double Dose: Do not take a double dose to make up for a missed one.
  • Consult Your Healthcare Provider: If you are unsure about what to do or if you miss multiple doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Zaroxolyn (metolazone) may cause side effects, and it’s important to be aware of potential adverse reactions while taking this medication. Keep in mind that not everyone will experience these side effects, and some individuals may not experience any at all. If you have concerns or notice any unusual symptoms, it’s crucial to contact your healthcare provider. Common side effects of Zaroxolyn include:

  • Frequent Urination: Zaroxolyn is a diuretic, and increased urine production is a common and expected side effect.
  • Electrolyte Imbalance: Diuretics can lead to changes in electrolyte levels, particularly potassium. This can cause symptoms such as muscle weakness, irregular heartbeat, or cramping.
  • Dizziness or Lightheadedness: Changes in blood pressure or fluid balance can result in dizziness or lightheadedness, especially when standing up quickly.
  • Dehydration: Increased urine production may lead to dehydration, which can cause symptoms such as excessive thirst, dry mouth, and weakness.
  • Increased Blood Uric Acid Levels: This can contribute to gout in susceptible individuals.
  • Elevated Blood Sugar Levels: Metolazone may affect blood glucose levels, and individuals with diabetes should monitor their blood sugar closely.
  • Impaired Kidney Function: In some cases, diuretics may affect kidney function. Regular monitoring of kidney function through blood tests may be recommended.
  • Allergic Reactions: Some individuals may be allergic to sulfa drugs, and since metolazone is structurally related to sulfonamides, allergic reactions can occur. Seek medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to note that this is not an exhaustive list of side effects, and other side effects may occur. Additionally, individual responses to medications can vary, and the severity of side effects can differ from person to person. Always report any unusual or severe symptoms to your healthcare provider promptly.

If you experience a medical emergency or severe allergic reaction, seek immediate medical attention. When taking any medication, it’s crucial to weigh the potential benefits against the risks and follow your healthcare provider’s guidance closely.

What should I know about storage and disposal of this medication?


  • Room Temperature: Store Zaroxolyn at room temperature away from light and moisture.
  • Specific Storage Instructions: Follow any specific storage instructions provided by your pharmacist or healthcare provider.
  • Keep Out of Reach of Children: As with all medications, keep Zaroxolyn out of the reach of children.


  • Follow Local Regulations: Dispose of unused or expired medications according to local regulations. Do not flush them down the toilet unless instructed to do so.
  • Pharmacy Disposal Programs: Many pharmacies have programs for the safe disposal of medications. Check with your local pharmacy to see if they offer such services.

In case of emergency/overdose

  • Seek Immediate Medical Attention: In case of overdose or emergency, seek immediate medical attention or call your local poison control center.
  • Symptoms of Overdose: Symptoms of overdose may include severe dizziness, weakness, confusion, dehydration, and electrolyte imbalance.
  • Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can lead to serious health consequences.

What other information should I know?

  • Regular Monitoring: Regular monitoring of blood pressure, electrolyte levels (especially potassium), and kidney function may be recommended by your healthcare provider.
  • Inform Healthcare Provider: Inform your healthcare provider about all the medications, supplements, and over-the-counter drugs you are taking to avoid potential interactions.
  • Allergic Reactions: If you experience symptoms of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.
  • Follow Prescribing Instructions: Take Zaroxolyn exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking it without consulting them.
  • Regular Check-ups: Attend regular check-ups with your healthcare provider to monitor the effectiveness of the medication and assess any potential side effects.
  • Medical Conditions: Inform your healthcare provider about any changes in your health status or the development of new medical conditions.

Always follow your healthcare provider’s instructions and guidance for the safe and effective use of Zaroxolyn. If you have specific concerns or questions about your medication, do not hesitate to reach out to your healthcare provider or pharmacist for clarification.

Copyright © 2023