WARNING

Xywav (calcium, magnesium, potassium, and sodium oxybates) is a medication prescribed for the treatment of narcolepsy. Like any medication, it comes with potential risks and side effects. It’s important to note that the information provided here is a brief overview, and individuals should consult with their healthcare providers for personalized advice. Common risks associated with Xywav include:

• Central Nervous System Effects: Xywav is a central nervous system depressant and can cause dizziness, drowsiness, and impair alertness. Caution is advised, especially when driving or operating machinery.
• Respiratory Depression: Xywav can slow down breathing, and this risk may be increased, especially at higher doses. Individuals with respiratory conditions should be closely monitored.
• Seizures: Xywav may lower the seizure threshold, so caution is advised, particularly in individuals with a history of seizures.
• Psychiatric Effects: Xywav has been associated with psychiatric symptoms such as depression, anxiety, and confusion. Changes in mood or behavior should be reported to healthcare providers.
• Interaction with Alcohol and Sedatives: Xywav can have additive effects with alcohol and other sedative medications, leading to increased central nervous system depression. Alcohol consumption should be avoided.
• Sodium Content: Xywav contains sodium, and individuals on a sodium-restricted diet should be cautious about their sodium intake.
• Pregnancy and Breastfeeding: The safety of Xywav during pregnancy and breastfeeding is not well-established, and the risks and benefits should be carefully evaluated by healthcare providers.
• Tolerance and Dependence: Tolerance or dependence may develop with long-term use. Abrupt discontinuation can lead to withdrawal symptoms, and dosage adjustments should be done under medical supervision.

It’s important for individuals prescribed Xywav to communicate openly with their healthcare providers about their medical history, existing conditions, and any concerns or side effects they may experience. This information is based on the knowledge, and there may have been updates or changes since then. Always refer to the most current prescribing information and consult with a healthcare professional for the latest guidance.

Why is this medication prescribed?

Xywav is a medication used for the treatment of narcolepsy in adults and pediatric patients aged 7 years and older. It contains a combination of two medications: calcium, magnesium, potassium, and sodium oxybates. These components are similar to those found in another medication called Xyrem, but Xywav is formulated as an oral solution with lower sodium content.

Narcolepsy is a chronic sleep disorder characterized by excessive daytime sleepiness, cataplexy (sudden loss of muscle strength), hallucinations, and sleep paralysis. Xywav, is a central nervous system depressant and is thought to work by affecting certain neurotransmitters in the brain.

How should this medicine be used?

It’s important to note that prescribing and usage information may change, and you should always follow the specific instructions provided by your healthcare provider and the medication’s official prescribing information. The following are general guidelines and may not cover all aspects of Xywav use:

• Dosage: The dosage of Xywav is individualized based on the patient’s weight and specific medical conditions. The dosage is typically divided into two doses per night.
• Administration: Xywav is an oral solution and should be taken by mouth. It is usually taken at bedtime and then 2.5 to 4 hours later.
• Preparation: The medication is supplied as a liquid and should be mixed with water before use. The patient or caregiver should follow specific instructions for preparing the solution.
• Monitoring: Patients should be monitored for side effects and changes in response to the medication.
• Food and Drink: Xywav should be taken on an empty stomach, at least 2 hours after eating.
• Safety Measures: Due to the sedative nature of the medication, caution should be exercised regarding activities requiring alertness, such as driving.
• Regular Follow-ups: Regular follow-up appointments with the healthcare provider are crucial to monitor the patient’s response to treatment and adjust the dosage if necessary.

Always consult with your healthcare provider for the most up-to-date information and specific instructions tailored to your individual needs. If you or someone you know has been prescribed Xywav, it’s important to follow the healthcare provider’s recommendations closely and communicate any concerns or side effects promptly.

Other uses for this medicine

As of last update, Xywav was primarily indicated for narcolepsy and related symptoms. It’s important not to use medications for purposes other than what they are prescribed for without consulting your healthcare provider.

What special precautions should I follow?

When using Xywav, there are several special precautions and considerations that individuals should be aware of:

• Central Nervous System Depression: Xywav is a central nervous system depressant, and its use may impair the ability to operate machinery, drive a car, or perform other potentially dangerous activities. Caution should be exercised, especially when starting the medication or adjusting the dosage.
• Respiratory Depression: Xywav can cause respiratory depression, which is a slowing of breathing. This risk may be increased in individuals with respiratory conditions. Patients should be monitored for signs of respiratory depression.
• Sodium Intake: Xywav contains sodium, and individuals on a sodium-restricted diet should be cautious about their sodium intake while using this medication. Patients should follow the specific dietary recommendations provided by their healthcare provider.
• Seizures: Xywav has the potential to increase the risk of seizures. Patients with a history of seizures should be closely monitored.
• Pregnancy and Breastfeeding: The safety of Xywav during pregnancy and breastfeeding is not well-established, and healthcare providers will carefully weigh the potential benefits and risks before prescribing it in these situations.
• Alcohol and Sedative Interaction: Xywav can have additive effects with alcohol and other sedative medications. Patients should avoid alcohol and inform their healthcare provider about all medications being taken.
• Psychiatric Effects: Xywav has been associated with psychiatric symptoms, including depression, anxiety, and confusion. Patients should report any changes in mood or behavior to their healthcare provider.
• Kidney Function: The medication may be excreted by the kidneys, and individuals with impaired kidney function may need dosage adjustments.

Always follow your healthcare provider’s instructions and communicate any concerns or side effects promptly. It’s essential to have open and transparent communication with your healthcare team to ensure the safe and effective use of any medication. If you have specific questions about Xywav or its use, consult your healthcare provider for the most accurate and up-to-date information.

What special dietary instructions should I follow?

• Empty Stomach: Xywav is usually taken on an empty stomach, at least 2 hours after eating.
• Low-Sodium Diet: If you are on a low-sodium diet, discuss dietary considerations with your healthcare provider.

What should I do if I forget a dose?

• Take as Soon as Possible: If you forget a dose, take it as soon as you remember, but make sure it’s not too close to the next scheduled dose.
• Skip if Close to Next Dose: If it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Dose: Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Xywav (calcium, magnesium, potassium, and sodium oxybates) is a medication used to treat cataplexy or excessive daytime sleepiness in patients with narcolepsy. It is a controlled substance, and its use requires close supervision by healthcare professionals.

It’s important to note that information about medications can change over time, and new side effects may be identified. Always consult with a healthcare professional or refer to the most recent prescribing information for the most up-to-date details.

As of my last update, common side effects of Xywav may include:

• Central Nervous System Effects:
  • Dizziness
  • Headache
  • Sleep disturbance
  • Tremor
• Gastrointestinal Effects:
  • Nausea
  • Vomiting
  • Abdominal pain
• Other Common Side Effects:
  • Weight loss
  • Decreased appetite
  • Sleepwalking
• Serious Side Effects:
  • Respiratory depression (particularly when used with other central nervous system depressants)
  • Sleepwalking, which can lead to injuries
  • Depression, suicidal thoughts, and other psychiatric symptoms

Patients taking Xywav should be closely monitored, and any concerning side effects should be reported to a healthcare professional promptly. It’s crucial to follow the prescribed dosage and instructions and to inform the healthcare provider about any other medications or substances being used concurrently.

Since the information provided here might be outdated, please consult a healthcare professional or refer to the latest prescribing information for Xywav for the most accurate and current information.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage:
  • Store Xywav at room temperature away from light and moisture.
  • Keep it out of reach of children and pets.
• Disposal:
  • Dispose of unused or expired medications following the specific guidelines provided by your healthcare provider or pharmacist.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so.

In case of emergency/overdose

• Emergency Assistance: In case of an overdose or if someone has ingested Xywav accidentally, seek emergency medical attention or contact your local poison control center.
• Symptoms of Overdose: Overdose symptoms may include confusion, difficulty breathing, seizures, loss of consciousness, and severe dizziness.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take Xywav exactly as prescribed by your healthcare provider. Do not adjust the dosage without consulting them.
• Avoid Alcohol and Sedatives: Avoid alcohol and other medications that have a sedative effect while taking Xywav, as this can increase the risk of central nervous system depression.
• Regular Follow-Up: Attend regular follow-up appointments with your healthcare provider to monitor your response to the medication and adjust the dosage if needed.
• Inform Healthcare Provider: Inform your healthcare provider of all medications, including over-the-counter drugs and supplements, that you are taking.
• Medical Conditions: Inform your healthcare provider of any medical conditions you have, especially if you have a history of seizures, respiratory conditions, or psychiatric disorders.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Xywav with your healthcare provider.
• Caution with Driving and Machinery: Xywav may cause dizziness and drowsiness. Use caution when operating machinery or driving, especially when starting the medication or adjusting the dosage.
• Sodium Intake: If you are on a sodium-restricted diet, discuss dietary considerations with your healthcare provider.
• Report Side Effects: Report any unusual or severe side effects to your healthcare provider.

Always consult with your healthcare provider for specific instructions and guidance related to your individual health and circumstances. This information is based on general guidelines and may not cover all aspects of Xywav use. If there are updates or changes to the prescribing information after last update, your healthcare provider will have the most current information.