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Xtandi (Generic Enzalutamide)

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Why is this medication prescribed?

Enzalutamide is a medication used in the treatment of prostate cancer. It is an androgen receptor inhibitor, and it is primarily prescribed for the following indications:

  • Metastatic Castration-Resistant Prostate Cancer (mCRPC): Enzalutamide is used for the treatment of metastatic castration-resistant prostate cancer in adult men. This refers to prostate cancer that has spread to other parts of the body and is resistant to medical or surgical treatments that lower testosterone.
  • Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC): Enzalutamide is also prescribed for the treatment of non-metastatic castration-resistant prostate cancer in adult men who are at high risk of developing metastasis. This is a form of prostate cancer that does not yet show signs of spreading to other parts of the body but is resistant to hormonal therapies that lower testosterone.

How should this medicine be used?

Enzalutamide is a medication used in the treatment of prostate cancer. It belongs to a class of drugs known as anti-androgens, and it works by blocking the effects of androgens (male hormones) in the body. Here are general guidelines on how Enzalutamide is typically used:

  • Prescription and Dosage: Enzalutamide is a prescription medication, and you should only take it under the supervision of a healthcare professional. The dosage may vary based on individual health conditions, the stage of prostate cancer, and other factors. Always follow the prescribed dosage and administration schedule.
  • Administration: Enzalutamide is usually taken orally, with or without food. It’s essential to swallow the capsule whole with a glass of water. Do not crush, chew, or open the capsules.
  • Consistency: Take Enzalutamide at the same time each day to maintain a consistent level of the medication in your body.
  • Follow Healthcare Provider’s Instructions: Always follow the specific instructions provided by your healthcare provider or pharmacist. If you have any questions or concerns about the medication, consult your healthcare professional.
  • Monitoring: Your healthcare provider may monitor your response to Enzalutamide through regular check-ups, blood tests, and other assessments. Inform your healthcare provider about any side effects or changes in your health.
  • Missed Dose: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up on doses to make up for a missed one.
  • Precautions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions. If you experience severe side effects or allergic reactions, seek medical attention promptly.
  • Storage: Store Enzalutamide at room temperature, away from light and moisture.
  • Pregnancy and Breastfeeding: Enzalutamide can cause harm to an unborn baby, so it is crucial to use effective contraception during treatment if you are sexually active and capable of fathering a child. Pregnant or breastfeeding individuals should avoid handling broken or crushed capsules.

Always consult with your healthcare provider for personalized advice and guidance based on your specific medical condition and history. This information is a general guide and not a substitute for professional medical advice.

Other uses for this medicine

Enzalutamide is primarily used for the treatment of metastatic and non-metastatic castration-resistant prostate cancer in men. It is an androgen receptor inhibitor specifically designed for this purpose. However, it’s important to note that the information may have changed, and you should consult with a healthcare professional or refer to the latest medical resources for the most current information.

What special precautions should I follow?

Regarding special precautions for enzalutamide, it’s crucial to discuss your medical history, current medications, and any other relevant health information with your healthcare provider before starting this medication. Here are some general precautions associated with enzalutamide:

  • Pregnancy and Breastfeeding: Enzalutamide may cause harm to a developing fetus, and it is not intended for use in women. If there is a possibility of pregnancy, effective contraception should be used during treatment, and men should not father a child during and for at least 3 months after stopping enzalutamide.
  • Liver Function: Enzalutamide is metabolized by the liver, and caution is advised in patients with pre-existing liver conditions. Regular monitoring of liver function may be recommended during treatment.
  • Seizures: Enzalutamide has been associated with an increased risk of seizures. Patients with a history of seizures or other factors that may predispose them to seizures should be closely monitored, and the decision to use enzalutamide should be made with caution.
  • Interactions with Other Medications: Enzalutamide may interact with certain medications, including anticoagulants, antiplatelet drugs, and drugs that are metabolized by the liver. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins.
  • Cardiovascular Risk: There have been reports of an increased risk of cardiovascular events in patients taking enzalutamide. Patients with a history of cardiovascular disease should be monitored closely.

It’s crucial to follow your healthcare provider’s instructions carefully, attend regular check-ups, and communicate any concerns or side effects promptly. If you have specific questions or concerns about enzalutamide, it’s best to discuss them with your healthcare team. They can provide information tailored to your individual health situation and needs.

What special dietary instructions should I follow?

As of my last update, there were no specific dietary restrictions associated with enzalutamide. However, individual healthcare providers may provide personalized guidance based on a patient’s overall health and medical history.

What should I do if I forget a dose?

If you forget to take a dose of enzalutamide, the general advice is to take it as soon as you remember. However, if it is almost time for your next scheduled dose, it’s usually recommended to skip the missed dose and continue with your regular dosing schedule. It’s important not to take a double dose to make up for a missed one.

What side effects can this medication cause?

Enzalutamide, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person.

Common side effects of enzalutamide may include:

  • Fatigue: Feeling tired or lacking energy is a common side effect.
  • Hot Flashes: Many patients experience episodes of sudden warmth, often in the upper body and face.
  • Hypertension (High Blood Pressure): Enzalutamide may lead to an increase in blood pressure.
  • Headache: Some individuals may experience headaches while taking enzalutamide.
  • Joint Pain and Muscle Pain: Pain in the joints and muscles can occur.
  • Diarrhea: Digestive issues, including diarrhea, may occur.
  • Nausea: Some people may feel nauseous.
  • Edema (Fluid Retention): Swelling, typically in the legs and feet, can occur.
  • Decreased Appetite: Some individuals may experience a reduced desire to eat.
  • Seizures: While uncommon, enzalutamide has been associated with an increased risk of seizures.

It’s important to report any side effects or concerns to your healthcare provider promptly. Additionally, there may be other side effects not listed here, and individual responses to medications can vary.

In some cases, the benefits of taking enzalutamide in managing prostate cancer may outweigh the potential side effects. Your healthcare provider can help you understand the risks and benefits and work with you to manage any side effects that may occur.

If you experience severe or persistent side effects, contact your healthcare provider immediately. They can provide guidance on whether any adjustments to the treatment plan are needed.

What should I know about storage and disposal of this medication?

Storage and Disposal of Enzalutamide:

  • Storage: Store enzalutamide at room temperature, away from excessive heat and moisture. Keep it in its original packaging or container, and protect it from light.
  • Keep Out of Reach of Children: Store medications out of reach of children and pets.
  • Disposal: Follow local regulations for the proper disposal of medications. Do not flush enzalutamide down the toilet or pour it into a drain unless instructed to do so.

In case of emergency/overdose

In the case of a suspected overdose or if someone has ingested enzalutamide accidentally, seek emergency medical attention or contact a poison control center immediately. Symptoms of an overdose may include severe nausea, vomiting, seizures, or other serious side effects.

What other information should I know

  • Regular Follow-Up: Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness of the treatment and assess for any side effects.
  • Laboratory Tests: Your healthcare provider may order regular blood tests, including liver function tests, to monitor how your body is responding to enzalutamide.
  • Interactions with Other Medications: Inform your healthcare provider about all medications, supplements, and vitamins you are taking, as enzalutamide may interact with certain drugs.
  • Handling for Women: Women who are pregnant or planning to become pregnant should not handle enzalutamide due to the potential risk to the fetus.
  • Inform Healthcare Providers: Before undergoing any surgical or dental procedures, inform the healthcare professionals involved that you are taking enzalutamide.
  • Patient Assistance Programs: Some pharmaceutical companies offer patient assistance programs that provide financial assistance or free medications to eligible individuals. Check with your healthcare provider or the manufacturer for information on any available programs.

Always follow your healthcare provider’s instructions, read the medication guide provided with enzalutamide, and seek clarification if you have any questions. If you experience any adverse effects or have concerns about the medication, contact your healthcare provider promptly. The information provided here is general and may not cover all individual circumstances, so it’s important to discuss your specific situation with your healthcare team.

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