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Xerava (Generic Eravacycline Injection)

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Why is this medication prescribed?

Xerava (eravacycline) is a tetracycline-class antibiotic that has been approved for the treatment of complicated intra-abdominal infections (cIAI). It is used in adults when alternative treatments are not suitable.

Complicated intra-abdominal infections are serious infections that occur in the abdomen and may involve various organs such as the stomach, liver, gallbladder, appendix, and others. These infections can be caused by a variety of bacteria, and Xerava is specifically designed to target these bacteria and help combat the infection.

How should this medicine be used?

Xerava is indicated for the treatment of complicated intra-abdominal infections caused by susceptible Gram-negative and Gram-positive microorganisms.

Dosage and Administration:

  • Dosage: The recommended dose of Xerava is typically administered intravenously (IV) over a specific period.
  • Frequency: The frequency and duration of treatment may vary based on the severity of the infection and the response to treatment. Your healthcare provider will determine the appropriate dosage regimen.
  • Administration: Xerava is administered by a healthcare professional in a hospital setting. It is not usually prescribed for self-administration.
  • Duration: The treatment duration will depend on the specific infection being treated. It is important to complete the full course of antibiotics as prescribed by your healthcare provider, even if symptoms improve before the medication is finished.

Administration Precautions:

  • Xerava is administered through an IV line, and it is crucial to follow proper sterile techniques during the administration.
  • Before starting Xerava, inform your healthcare provider about any allergies, other medications you are taking, and your medical history.


  • Your healthcare provider may monitor your response to treatment through clinical assessments and laboratory tests.

It’s essential to follow your healthcare provider’s instructions carefully and to report any side effects or concerns promptly. Additionally, this information might have changed since my last update, so it’s crucial to consult with a healthcare professional or refer to the most recent medical literature for the latest guidance on Xerava and its use.

Other uses for this medicine

Xerava (eravacycline) is primarily indicated for the treatment of complicated intra-abdominal infections (cIAI) in adults. It’s important to note that the use of antibiotics, including Xerava, should be guided by a healthcare professional, and the medication should be taken only for the specific condition for which it is prescribed.

What special precautions should I follow?

As for special precautions when using Xerava, here are some general considerations:

  • Allergies: Inform your healthcare provider if you are allergic to tetracycline antibiotics or any other ingredients in Xerava.
  • Medical History: Provide your healthcare provider with a comprehensive medical history, including any history of kidney problems or other pre-existing conditions.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Xerava with your healthcare provider. The safety of Xerava during pregnancy and breastfeeding may not be well-established.
  • Drug Interactions: Inform your healthcare provider about all medications, vitamins, and herbal supplements you are currently taking. Certain medications may interact with Xerava, affecting its efficacy or increasing the risk of side effects.
  • Liver and Kidney Function: Individuals with impaired liver or kidney function may require adjustments to the dosage of Xerava. Your healthcare provider will assess your overall health before prescribing this medication.
  • Photosensitivity: Tetracycline antibiotics, including Xerava, can increase sensitivity to sunlight. It’s advisable to take precautions such as using sunscreen and protective clothing to minimize exposure to sunlight and UV rays.
  • Completion of Course: It’s important to complete the entire course of Xerava as prescribed by your healthcare provider, even if your symptoms improve before the medication is finished. Stopping antibiotics prematurely may lead to the development of antibiotic-resistant bacteria.
  • Side Effects: Be aware of potential side effects and report any unusual or severe reactions to your healthcare provider promptly.

Please note that this information is based on knowledge, and there may have been developments or updates since then. Always follow your healthcare provider’s instructions, and if you have any specific concerns or questions about Xerava, consult with your healthcare professional for the most accurate and current information.

What special dietary instructions should I follow?

Xerava is typically administered intravenously in a healthcare setting, so specific dietary instructions may not be applicable. However, it’s crucial to stay well-hydrated during the course of treatment unless otherwise advised by your healthcare provider.

What should I do if I forget a dose?

If you forget to apply a dose of Xerava:

  • If you miss a dose of Xerava, contact your healthcare provider or the medical staff overseeing your treatment as soon as possible.
  • It’s essential to follow your provider’s instructions regarding missed doses. In some cases, they may recommend adjusting the timing of the next dose or may administer the missed dose if it’s still within a reasonable timeframe.

What side effects can this medication cause?

Like any medication, Xerava (eravacycline) can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed. The severity of side effects can also vary. If you are prescribed Xerava, it’s crucial to discuss potential side effects with your healthcare provider and report any unusual or severe reactions promptly. Common side effects and adverse reactions associated with Xerava may include:

  • Nausea: Feeling sick to your stomach is a common side effect.
  • Vomiting: Some individuals may experience vomiting as a side effect of Xerava.
  • Diarrhea: Diarrhea can occur as a result of changes in the gut microbiota.
  • Headache: Some people may experience headaches while taking Xerava.
  • Elevated Liver Enzymes: Xerava may cause increases in liver enzyme levels, which can be monitored through blood tests.
  • Infusion Site Reactions: Since Xerava is administered intravenously, there may be local reactions at the infusion site, such as redness or pain.
  • Increased Blood Pressure: There have been reports of increased blood pressure in some individuals taking Xerava.
  • Photosensitivity: Tetracycline antibiotics, including Xerava, can increase sensitivity to sunlight, leading to sunburn more easily.
  • Allergic Reactions: In rare cases, individuals may experience allergic reactions such as rash, itching, or swelling. Serious allergic reactions are uncommon but can occur.

It’s important to seek medical attention if you experience severe or persistent side effects. Additionally, some side effects may not be immediately apparent, so regular monitoring by healthcare professionals is often necessary during the course of treatment.

This list is not exhaustive, and there may be other side effects associated with Xerava. Always refer to the medication’s prescribing information, and consult with your healthcare provider for the most accurate and up-to-date information tailored to your specific health condition. If you have concerns about side effects or notice any unusual symptoms while taking Xerava, do not hesitate to contact your healthcare provider for guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal of Xerava:


  • Temperature: Store Xerava as directed by your healthcare provider. Typically, it should be stored at room temperature, away from excessive heat and moisture.
  • Refrigeration: In some cases, Xerava may need to be stored in a refrigerator. Follow the specific storage instructions provided with the medication.
  • Protect from Light: Certain medications are sensitive to light, so it’s essential to store them in packaging that protects them from light exposure.


  • Do Not Flush: Do not flush Xerava down the toilet unless instructed to do so. Check with your local waste management or pharmacy for guidance on safe disposal.
  • Medication Take-Back Programs: Many communities have medication take-back programs or specific drop-off locations for safe disposal of medications. Check with your local pharmacy or health department.
  • Sealed Containers: If no take-back options are available, you can dispose of Xerava in a sealed container with an undesirable substance (e.g., coffee grounds or cat litter) and throw it in the household trash.

In case of emergency/overdose

  • In case of an emergency or suspected overdose, seek immediate medical attention or contact your local poison control center.
  • Symptoms of overdose may include severe nausea, vomiting, and diarrhea. Provide healthcare professionals with as much information as possible, including the amount of Xerava taken and when.

What other information should I know?

  • Follow Instructions: Always take Xerava exactly as prescribed by your healthcare provider. Do not alter the dosage or stop the medication without consulting your healthcare professional.
  • Regular Monitoring: Your healthcare provider may conduct regular monitoring, including laboratory tests, to assess your response to treatment and to check for any potential side effects.
  • Inform Healthcare Providers: Inform all healthcare providers, including dentists and surgeons, about your use of Xerava before any medical procedures or treatments.
  • Allergies: If you develop signs of an allergic reaction (e.g., rash, itching, swelling), seek medical attention immediately.
  • Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Xerava may interact with other substances.
  • Stay Hydrated: Ensure adequate hydration during the course of treatment unless otherwise advised by your healthcare provider.

These are general guidelines, and specific instructions may vary. Always consult your healthcare provider and carefully read the medication’s prescribing information for the most accurate and up-to-date guidance on storage, disposal, and emergency situations related to Xerava. If you have questions or concerns, discuss them with your healthcare professional.

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