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Xenleta (Generic Lefamulin)

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Why is this medication prescribed?

Lefamulin is an antibiotic that was approved for the treatment of community-acquired bacterial pneumonia (CABP) in adults. It belongs to a class of antibiotics called pleuromutilins and works by inhibiting bacterial protein synthesis.

Colds, the flu, and other viral diseases cannot be treated with antibiotics like lefamulin. Antibiotic use that is not necessary raises the likelihood of developing a later infection that is resistant to antibiotic treatment.

How should this medicine be used?

Lefamulin is typically administered as an oral. The specific dosage and administration instructions can vary based on the severity of the infection, the patient’s overall health, and other individual factors. It is crucial to follow the prescribing physician’s instructions and the information provided on the medication’s label. Below are general guidelines, but it’s important to note that individualized recommendations should be obtained from a healthcare professional:

  • Oral Tablets: Lefamulin is available in oral tablet form. If you are prescribed the oral form, it is usually taken with or without food.
  • Dosage: The dosage of lefamulin can vary depending on factors such as the type and severity of the infection and the patient’s age and health status.
  • Administration Schedule: Lefamulin is typically taken at regular intervals, and the schedule will be determined by the prescribing healthcare provider. It’s important to take the medication exactly as directed.
  • Completing the Course: Even if symptoms improve before completing the prescribed course, it is essential to finish the full course of lefamulin. This helps ensure that the infection is completely treated and reduces the risk of antibiotic resistance.
  • Missed Dose: If a dose is missed, it’s important to take it as soon as remembered. However, if it is almost time for the next dose, it’s advisable to skip the missed dose and continue with the regular schedule. It’s crucial not to double up on doses.
  • Side Effects and Concerns: If any side effects or concerns arise while taking lefamulin, it is important to contact the prescribing healthcare provider promptly. This includes reporting any unusual symptoms, allergic reactions, or severe side effects.

Always consult with your healthcare provider for personalized advice regarding the use of lefamulin, as individual circumstances may vary. This information is provided as a general guideline and may not cover all aspects of lefamulin use.

Other uses for this medicine

Lefamulin was primarily approved for the treatment of community-acquired bacterial pneumonia (CABP) in adults. Its approval and recommended uses may have expanded since then, so it’s important to consult the most recent medical literature or your healthcare provider for the latest information.

What special precautions should I follow?

Regarding special precautions for lefamulin, it’s crucial to follow your healthcare provider’s advice and consider the following general precautions:

  • Allergies: Inform your healthcare provider of any allergies to medications, including antibiotics or other substances. This information is crucial to avoid allergic reactions.
  • Medical History: Provide a comprehensive medical history, including any history of liver or kidney problems, gastrointestinal issues, or any other significant health conditions.
  • Drug Interactions: Inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, herbal supplements, and vitamins. Certain medications may interact with lefamulin, potentially affecting its efficacy or increasing the risk of side effects.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The safety of lefamulin during pregnancy and breastfeeding may need to be evaluated, and alternative options may be considered.
  • Liver Function: Lefamulin is metabolized by the liver, so individuals with pre-existing liver conditions may need special monitoring. Your healthcare provider may perform liver function tests during treatment.
  • Kidney Function: Individuals with impaired kidney function may also require careful monitoring during lefamulin treatment.
  • Clostridium difficile Infection: Antibiotic use, including lefamulin, can sometimes lead to the overgrowth of bacteria called Clostridium difficile, causing a severe form of diarrhea. If you experience persistent or severe diarrhea during or after treatment, inform your healthcare provider.
  • Driving and Operating Machinery: Lefamulin may cause dizziness. If you experience this side effect, use caution when driving or operating machinery.

Remember that these are general precautions, and individual circumstances may vary. Always follow your healthcare provider’s instructions and communicate any concerns or side effects promptly. If you have specific questions about lefamulin or any other medication, it’s best to consult with your healthcare provider or pharmacist for the most up-to-date and personalized information.

What special dietary instructions should I follow?

There are typically no specific dietary restrictions associated with lefamulin. However, it’s a good practice to take oral medications with or without food as directed by your healthcare provider unless stated otherwise.

What should I do if I forget a dose?

If you forget to take a dose of lefamulin, follow these general guidelines:

  • Oral Formulation: If it’s close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.
  • Consult Your Healthcare Provider: If you are unsure about what to do, or if you missed several doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Lefamulin, like any medication, may cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Below is a list of potential side effects associated with lefamulin:

  • Common Side Effects:
    • Nausea: Feeling an urge to vomit.
    • Diarrhea: Changes in bowel habits, which may be loose or more frequent than usual.
    • Elevated Liver Enzymes: Increased levels of certain liver enzymes may occur in some individuals.
  • Less Common Side Effects:
    • Headache: Pain or discomfort in the head.
    • Vomiting: The act of expelling stomach contents through the mouth.
  • Serious Side Effects:
    • Allergic Reactions: Serious allergic reactions are rare but can occur. Seek medical attention immediately if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
    • Clostridium difficile Infection: Prolonged use of antibiotics like lefamulin can lead to the overgrowth of bacteria called Clostridium difficile, causing severe diarrhea.

It’s important to contact your healthcare provider if you experience any side effects, especially if they are persistent, severe, or if you are concerned about them. Additionally, if you notice signs of an allergic reaction (such as difficulty breathing, swelling, or severe rash), seek emergency medical attention.

This is not an exhaustive list of side effects, and individuals may react differently to the medication. Always consult with your healthcare provider or pharmacist for personalized information based on your medical history and current health status. If you have any concerns or questions about the side effects of lefamulin, it’s crucial to discuss them with your healthcare provider.

What should I know about storage and disposal of this medication?


  • Temperature: Store lefamulin according to the specific instructions on the medication label. Generally, it is stored at room temperature, but it’s crucial to follow the guidelines provided by the manufacturer.
  • Protect from Light and Moisture: Some medications can be sensitive to light and moisture. Follow any specific instructions regarding exposure to light and moisture.
  • Keep Out of Reach of Children: Store medications in a place that is out of reach of children and pets.


  • Follow Local Guidelines: Dispose of lefamulin according to local guidelines and regulations. Some medications have specific disposal instructions to minimize environmental impact.
  • Do Not Flush: Do not flush medications down the toilet unless instructed to do so. Check with your local pharmacy or health department for safe disposal options.

In case of emergency/overdose

  • Seek Immediate Medical Attention: In case of an overdose or if you suspect someone has taken too much lefamulin, seek emergency medical attention or contact a poison control center immediately.
  • Symptoms of Overdose: Symptoms of overdose can vary but may include severe nausea, vomiting, diarrhea, or other adverse reactions. It’s important to get prompt medical help.

What other information should I know?

  • Follow Healthcare Provider’s Instructions: Take lefamulin exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your healthcare provider.
  • Complete the Course: Finish the entire prescribed course of lefamulin, even if symptoms improve before the medication is finished. This helps ensure the infection is fully treated.
  • Inform Healthcare Provider: Inform your healthcare provider of all medications, supplements, and medical conditions you have before starting lefamulin. This can help prevent potential interactions.
  • Follow-Up Appointments: Attend any follow-up appointments scheduled by your healthcare provider. These appointments may be essential to monitor your response to the medication and address any concerns.
  • Allergic Reactions: Be vigilant for signs of allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if any of these symptoms occur.

Always consult with your healthcare provider or pharmacist for personalized advice and the most up-to-date information. If you have any questions or concerns about lefamulin or its use, do not hesitate to reach out to your healthcare provider for guidance.

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