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Wellcovorin (Generic Leucovorin)

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Why is this medication prescribed?

Wellcovorin, also known as leucovorin, is a medication that is commonly used in combination with certain cancer medications (such as methotrexate) to counteract the toxic effects of these drugs on normal cells. It is also used in the treatment of folate deficiency. Wellcovorin is a brand name for leucovorin, which is a form of folic acid (vitamin B9). It is commonly prescribed in medical settings for several purposes:

  • Folate Deficiency: Wellcovorin is used to treat or prevent folic acid deficiency. Folic acid is essential for the formation of DNA and red blood cells.
  • Methotrexate Rescue: In cancer treatment, methotrexate is a medication that interferes with the growth of certain cancer cells. However, it can also affect normal cells, including those in the bone marrow. Wellcovorin is often given in a process known as “rescue” to counteract the effects of high-dose methotrexate and protect normal cells.
  • Overdose of Folate Antagonists: Wellcovorin may be used in cases of overdose or toxic reactions to medications that act as folate antagonists, such as certain antibiotics.

How should this medicine be used?

The specific instructions for using Wellcovorin can vary based on the condition being treated and the other medications involved. Therefore, it’s crucial to follow your doctor’s instructions and the dosing guidelines provided on the medication label. Here are some general guidelines:

  • Dosage: The dosage of Wellcovorin can vary depending on the specific situation and the medications being used in conjunction. Your doctor will determine the appropriate dosage for your condition.
  • Administration: Wellcovorin can be administered orally or through injection. The method of administration will depend on your specific treatment plan. If it’s an injection, a healthcare professional will typically administer it.
  • Frequency: The frequency of administration will be determined by your doctor. It may be given daily, weekly, or at other intervals, depending on the treatment protocol.
  • Follow-up: Regular follow-up appointments with your healthcare provider are essential to monitor your response to the treatment and adjust the dosage if necessary.
  • Duration of Treatment: The duration of treatment with Wellcovorin will depend on the specific medical condition being addressed. It’s important to complete the entire course of treatment as prescribed by your doctor.
  • Special Instructions: Depending on your medical history, your doctor may provide specific instructions. For example, if you have certain allergies or medical conditions, your doctor needs to be aware of them.
  • Side Effects: Be aware of potential side effects and contact your healthcare provider if you experience any unusual symptoms. Side effects can vary but may include nausea, vomiting, diarrhea, or allergic reactions.

Remember, this information is general, and you should always follow the specific instructions given by your healthcare provider. If you have any questions or concerns about how to use Wellcovorin, don’t hesitate to discuss them with your doctor or pharmacist.

Other uses for this medicine

In addition to its primary uses in cancer treatment, Wellcovorin (leucovorin) has other applications and is prescribed for various conditions. Some of these uses include:

  • Methotrexate Overdose: Wellcovorin can be used as an antidote to treat and counteract the toxic effects of methotrexate in cases of overdose.
  • Colon Cancer Treatment: It may be used in combination with fluorouracil for the treatment of advanced colorectal cancer.
  • Rheumatoid Arthritis: In some cases, leucovorin has been used as a treatment for rheumatoid arthritis, particularly in combination with methotrexate.

What special precautions should I follow?

Regarding special precautions, it’s important to be aware of the following:

  • Allergies: Inform your healthcare provider if you are allergic to leucovorin or any other medications.
  • Medical History: Provide a comprehensive medical history, including information about any pre-existing conditions, such as kidney problems or certain blood disorders.
  • Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the risks and benefits of using Wellcovorin with your healthcare provider. It may be prescribed if the potential benefits outweigh the risks.
  • Interactions with Other Medications: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medicines, and herbal supplements. Wellcovorin can interact with certain medications.
  • Dosage Adherence: It’s crucial to adhere to the prescribed dosage and administration schedule. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider.
  • Monitoring: Regular monitoring of blood counts and other relevant parameters may be necessary during treatment with Wellcovorin.
  • Side Effects: Be aware of potential side effects, and contact your healthcare provider if you experience any unusual or severe symptoms.
  • Medical Emergencies: If you are receiving Wellcovorin for methotrexate rescue, it’s important to have access to medical care in case of an emergency.

Always follow your healthcare provider’s instructions and communicate openly about your health status and any concerns you may have. If you have questions or experience side effects, consult your healthcare provider promptly.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Wellcovorin. However, it’s generally important to maintain a balanced and healthy diet during cancer treatment. Certain foods and supplements may interact with medications, so it’s advisable to discuss your dietary habits with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Wellcovorin, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Wellcovorin (leucovorin) is generally well-tolerated, but like any medication, it can cause side effects. The severity and occurrence of side effects can vary from person to person. Common side effects may include:

  • Allergic Reactions: Some people may experience allergic reactions such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you observe any signs of an allergic reaction.
  • Nausea and Vomiting: Gastrointestinal symptoms like nausea and vomiting can occur. Inform your healthcare provider if these symptoms are severe.
  • Diarrhea: Diarrhea is another gastrointestinal side effect that may occur.
  • Skin Reactions: Skin reactions, including rash or redness, may occur.
  • Low Blood Calcium Levels: Leucovorin can affect calcium levels in the blood, leading to symptoms such as muscle spasms or twitching. Your healthcare provider may monitor your calcium levels during treatment.
  • Mouth Sores: Some people may develop sores in the mouth.
  • Injection Site Reactions: If Wellcovorin is administered by injection, there may be some local reactions at the injection site.
  • Fever: An elevation in body temperature (fever) can occur.

These are not the only possible side effects, and others may occur. It’s important to report any unexpected or severe symptoms to your healthcare provider. Additionally, certain side effects may be more likely to occur when Wellcovorin is used in combination with other chemotherapy drugs.

Remember that your healthcare provider has prescribed this medication because they have judged that the benefits outweigh the risks. If you have concerns about potential side effects or experience any adverse reactions, it’s crucial to communicate with your healthcare provider promptly. They can provide guidance on managing side effects and adjust the treatment plan if necessary.

What should I know about storage and disposal of this medication?


  • Room Temperature: Store Wellcovorin at room temperature away from light and moisture unless otherwise directed by your healthcare provider or the medication’s packaging.
  • Keep Away from Children: Store medications in a place that is out of reach of children and pets.
  • Do Not Freeze: Avoid freezing Wellcovorin.
  • Proper Packaging: Keep Wellcovorin in its original packaging or container to protect it from environmental factors.


  • Follow Local Regulations: Dispose of Wellcovorin according to local regulations for medication disposal. Many communities have specific guidelines for safe disposal.
  • Don’t Flush: Do not flush medications down the toilet unless instructed to do so. Flushing medications can contribute to water pollution.
  • Take-Back Programs: Check if there are any medication take-back programs or collection sites in your community where you can safely dispose of unused or expired medications.
  • Ask Pharmacist: If you’re unsure about how to dispose of Wellcovorin, consult your pharmacist for guidance.

In case of emergency/overdose

In case of emergency or overdose, contact your local emergency services or a poison control center immediately. If possible, have the medication packaging with you to provide necessary information to healthcare professionals.

What other information should I know?

  • Regular Follow-ups: Attend all scheduled appointments with your healthcare provider for regular follow-ups and monitoring.
  • Lab Tests: Your healthcare provider may order laboratory tests to monitor your response to Wellcovorin and to check for any side effects.
  • Inform Healthcare Providers: Keep your healthcare providers informed about all medications you are taking, including over-the-counter drugs and supplements.
  • Allergies: Inform any healthcare provider (such as emergency room staff or dentists) about your allergy to leucovorin or any other medications.
  • Pregnancy/Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Wellcovorin with your healthcare provider.

Always follow your healthcare provider’s instructions regarding the use, storage, and disposal of Wellcovorin. If you have any concerns or questions, don’t hesitate to reach out to your healthcare provider or pharmacist for clarification.

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