Why is this medication prescribed?

Vizimpro (dacomitinib) is a prescription medication used in the treatment of non-small cell lung cancer (NSCLC), specifically for patients with metastatic NSCLC that has certain genetic mutations. It belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs), which work by blocking specific proteins that play a role in the growth and spread of cancer cells.

How should this medicine be used?

Vizimpro (dacomitinib) is a prescription medication used in the treatment of non-small cell lung cancer (NSCLC) with specific genetic mutations. It is important to follow your healthcare provider’s instructions and the information provided with the medication. Here are general guidelines for how Vizimpro is typically used:

• Dosage: Take Vizimpro exactly as prescribed by your healthcare provider. The usual recommended dose is one tablet (45 mg) orally once daily.
• Timing: Vizimpro can be taken with or without food. Try to take it at the same time every day.
• Swallowing the Tablet: Swallow the tablet whole with a glass of water. Do not crush, cut, or chew the tablet.
• Other Medications: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as some may interact with Vizimpro.
• Follow-up Appointments: Attend all scheduled appointments with your healthcare provider. Regular check-ups and monitoring are essential to assess the effectiveness of the treatment and manage any potential side effects.
• Side Effects: Be aware of potential side effects and report any unusual symptoms or concerns to your healthcare provider promptly.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up to make up for a missed dose.
• Do Not Stop Abruptly: Do not stop taking Vizimpro without consulting your healthcare provider. Abruptly stopping the medication can have adverse effects on your condition.
• Storage: Store Vizimpro at room temperature away from light and moisture. Keep it out of reach of children.

Always follow your healthcare provider’s specific instructions, and if you have any questions or concerns about the use of Vizimpro, do not hesitate to discuss them with your healthcare team. They are there to provide guidance based on your individual health situation.

Other uses for this medicine

Vizimpro (dacomitinib) is primarily prescribed for the treatment of non-small cell lung cancer (NSCLC) with specific genetic mutations, particularly those with epidermal growth factor receptor (EGFR) mutations like exon 19 deletions or exon 21 L858R mutations. It is not generally used for other conditions. The decision to prescribe Vizimpro is based on the specific genetic profile of the patient’s lung cancer.

What special precautions should I follow?

Special precautions should be taken when using Vizimpro, and it’s important to discuss your medical history and any potential risks with your healthcare provider. Here are some general precautions associated with Vizimpro:

• Inform Your Healthcare Provider: Provide your healthcare provider with a comprehensive medical history, including information about any pre-existing medical conditions, allergies, or medications you are currently taking.
• Liver and Kidney Function: Vizimpro is metabolized by the liver, so inform your healthcare provider if you have liver problems. Also, discuss kidney function, as the drug is eliminated from the body through the kidneys.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant or planning to become pregnant. Vizimpro may cause harm to an unborn baby. Use effective contraception during treatment and for at least 17 days after the last dose. It is not recommended for use during breastfeeding.
• Lung Disease: Vizimpro may cause interstitial lung disease (ILD) or pneumonitis. Inform your healthcare provider if you experience new or worsening respiratory symptoms, such as cough, difficulty breathing, or fever.
• Eye Disorders: Vizimpro may cause keratitis, an inflammation of the cornea. If you experience eye symptoms such as eye pain, redness, sensitivity to light, or changes in vision, contact your healthcare provider.
• Skin Reactions: Serious skin reactions, including rash and acne, have been reported with Vizimpro. Inform your healthcare provider if you develop skin-related issues.
• Drug Interactions: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements, as they may interact with Vizimpro.

Always follow your healthcare provider’s instructions and attend regular check-ups to monitor your response to the medication and manage any potential side effects. If you have concerns or experience any unusual symptoms, contact your healthcare provider promptly.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Vizimpro. However, it’s crucial to maintain a balanced and healthy diet to support your overall well-being during cancer treatment. If you have any specific concerns or dietary restrictions, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Vizimpro:

• Take it as soon as you remember: If it’s close to the time of your next scheduled dose, skip the missed dose and take the next one at the regular time.
• Do not double up: Do not take a double dose to make up for the missed one. Taking extra doses can increase the risk of side effects without providing additional benefits.

What side effects can this medication cause?

Vizimpro (dacomitinib) may cause various side effects, and it’s important to be aware of them and promptly report any unusual or severe symptoms to your healthcare provider. Common side effects and potential adverse reactions associated with Vizimpro include:

• Diarrhea: Diarrhea is a common side effect of Vizimpro. Inform your healthcare provider if you experience persistent or severe diarrhea, as it can lead to dehydration and electrolyte imbalances.
• Skin Rash: Skin rash, including acneiform rash, may occur. It’s important to inform your healthcare provider if you develop a rash, as it could be a sign of a more serious skin reaction.
• Paronychia (Nail Infection): Inflammation of the tissue surrounding the nails, known as paronychia, can occur.
• Stomatitis (Inflammation of the Mouth): Vizimpro may cause inflammation of the mouth and mucous membranes. Inform your healthcare provider if you experience mouth sores or discomfort.
• Decreased Appetite: Some individuals may experience a decrease in appetite while taking Vizimpro.
• Dry Skin: Dry skin is a possible side effect.
• Fatigue: Feeling tired or fatigued may occur.
• Eye Disorders: Vizimpro may cause eye-related side effects, such as conjunctivitis (pink eye) or keratitis (inflammation of the cornea). Report any changes in vision, eye pain, or redness to your healthcare provider.
• Interstitial Lung Disease (ILD) or Pneumonitis: Serious lung problems, including ILD or pneumonitis, have been reported. Notify your healthcare provider if you experience new or worsening respiratory symptoms, such as cough, difficulty breathing, or fever.
• Hepatotoxicity: Vizimpro can affect the liver. Inform your healthcare provider if you experience symptoms such as yellowing of the skin or eyes (jaundice), dark urine, or persistent abdominal pain.

It’s important to note that individual experiences with medications can vary, and not everyone will experience these side effects. Your healthcare provider will monitor your response to the medication and may adjust the treatment plan if needed. If you have concerns about potential side effects or if you experience any symptoms that worry you, contact your healthcare provider for guidance.

What should I know about storage and disposal of this medication?

Storage and disposal of Vizimpro:

• Storage:
  • Store Vizimpro at room temperature, away from light and moisture.
  • Keep the medication in its original container or packaging.
  • Keep it out of reach of children and pets.
• Disposal:
  • Dispose of unused or expired medication properly. Check with your pharmacist or local waste disposal facility for guidance on the proper disposal of medications.
  • Do not flush Vizimpro down the toilet or throw it in the trash unless instructed to do so.

In case of emergency/overdose

In case of emergency/overdose of Vizimpro:

• If you suspect an overdose or experience severe side effects, seek emergency medical attention or contact your local poison control center immediately.
• Symptoms of overdose may include severe diarrhea, skin rash, and other side effects. It’s important to communicate with healthcare professionals promptly.

What other information should I know?

• Regular Monitoring: Attend all scheduled appointments with your healthcare provider for regular check-ups and monitoring of your response to Vizimpro.
• Follow Healthcare Provider’s Instructions: Take Vizimpro exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription drugs, over-the-counter medications, and herbal supplements, as they may interact with Vizimpro.
• Pregnancy and Contraception: If you are pregnant or planning to become pregnant, discuss this with your healthcare provider. Use effective contraception during treatment and for at least 17 days after the last dose.
• Breastfeeding: Vizimpro is not recommended during breastfeeding.
• Report Side Effects: Report any side effects or concerns to your healthcare provider promptly.
• Communication: Maintain open communication with your healthcare team. Discuss any questions or concerns you may have about Vizimpro or your overall treatment plan.

Always follow your healthcare provider’s advice and instructions. The information provided here is a general guide, and individual circumstances may vary. If you have specific questions or concerns about Vizimpro, consult with your healthcare provider or pharmacist for personalized information based on your health condition.