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Varubi (Generic Rolapitant Injection)

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Why is this medication prescribed?

In order to avoid nausea and vomiting that can happen a few days after taking some chemotherapy drugs, rolapitant injection is used in conjunction with other treatments. Rolapitant is a member of the antiemetics drug class. It functions by preventing the brain’s natural chemicals that induce nausea and vomiting, neurokinin and substance P.

How should this medicine be used?

A medical professional in a hospital or clinic will provide rolapitant injection intravenously (into a vein) as a solution (liquid). It is typically given intravenously two hours prior to the initiation of chemotherapy as a single dosage spread over 30 minutes.

When the drug is being infused, usually in the initial minutes, rolapitant injection can result in substantial side effects. While you are taking the drug, you will be closely observed by a physician or nurse. Inform your doctor right once if you encounter any of the following symptoms: breathing or swallowing difficulties, shortness of breath, swelling of the eyes, face, mouth, tongue, or throat, hives, rash, flushing, itching, chest discomfort, stomach pain or cramps, vomiting, dizziness, or fainting.

For the patient, request a copy of the manufacturer’s information from your pharmacist or physician.

Other uses for this medicine

Ask your doctor or pharmacist for more information if you think this medicine could be recommended for something else.

What special precautions should I follow?

Regarding special precautions for Rolapitant Injection, here are some important points to consider:

  • If you have an allergy to any of the following: soybean oil; legumes (beans, peanuts, peas, or lentils); rolapitant; other drugs; or any of the ingredients in rolapitant injection, let your doctor and pharmacist know. Get an ingredient list from your pharmacist.
  • Inform your physician if you take pimozide (Orap) or thioridazine. If you are on any of these medications, your doctor probably won’t want you to get rolapitant injection.
  • Inform your healthcare provider about all medications you are currently taking, including prescription, over-the-counter, and herbal supplements.
  • If you have liver disease or have ever had it, let your doctor know.
  • Inform your physician if you are nursing a baby, intend to get pregnant, or are already pregnant. Contact your doctor if you become pregnant while getting an injection of rolapitant.

Always follow the prescribed dosage and administration instructions provided by your healthcare provider. If you have any concerns or experience unexpected side effects while taking rolapitant, contact your healthcare professional promptly. This information is a general overview, and specific precautions may vary based on individual health circumstances and the latest medical guidelines.

What special dietary instructions should I follow?

Your healthcare provider or pharmacist will inform you if there are any specific dietary instructions or restrictions while taking Rolapitant Injection. Some medications may be taken with or without food, and your provider will provide guidance on the optimal way to take Rolapitant Injection.

What should I do if I forget a dose?

If you forget to take a dose of Rolapitant Injection:

  • If you forget a dose, it’s essential to contact your healthcare provider or follow the specific instructions provided with the medication.
  • Do not double the dose to make up for a missed one unless directed by your healthcare provider.

What side effects can this medication cause?

Rolapitant Injection may have adverse effects. If any of these symptoms are severe or persistent, let your doctor know:

  • Hiccups
  • Stomach pain
  • Decreased appetite
  • Dizziness
  • Heartburn
  • Mouth sores

Certain adverse effects may be dangerous. Call your doctor right away if you have any of these symptoms, or seek emergency care:

  • Fever, chills, sore throat, or other infection-related symptoms

Other adverse effects are possible with rolapitant injection. If you have any odd side effects while taking this medicine, contact your doctor.

What should I know about storage and disposal of this medication?

Here are important guidelines regarding the storage and disposal information about rolapitant injection:


  • Store the medication as directed on the packaging.
  • Keep it away from children and pets.
  • Protect it from light, moisture, and excessive heat.


  • Dispose of medications according to local regulations or guidelines.
  • Do not flush medications down the toilet unless specifically instructed to do so.
  • Check with your pharmacist or healthcare provider on the proper disposal method for the specific medication.

In case of emergency/overdose

  • In case of overdose or emergency, call your local emergency number immediately.
  • If possible, have the medication packaging available to provide information about the drug.

What other information should I know?

  • Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, and herbal supplements.
  • Report any side effects or concerns to your healthcare provider promptly.
  • Attend all scheduled follow-up appointments to monitor your response to the medication.

Remember, the information provided here is general, and it’s important to consult with your healthcare provider or pharmacist for specific instructions related to Rolapitant Injection. They can provide you with the most accurate and personalized information based on your medical history and the specific details of your treatment plan. If there have been updates or changes in medical guidelines since last update, your healthcare provider will have the latest information.

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