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Vabomere (Generic Meropenem and Vaborbactam Injection)

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Why is this medication prescribed?

Vabomere is typically prescribed for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis, caused by susceptible bacteria. It is important to note that the use of antibiotics, including Vabomere, should be guided by a healthcare professional based on the specific bacterial infection and the susceptibility of the bacteria to the medication.

Vabomere is a combination medication that contains two active ingredients:

  • Meropenem: This is a carbapenem antibiotic that works by inhibiting the synthesis of bacterial cell walls. It is effective against a broad spectrum of bacteria, including those that may be resistant to other classes of antibiotics.
  • Vaborbactam: This is a beta-lactamase inhibitor. Beta-lactamases are enzymes produced by some bacteria that can break down certain antibiotics, rendering them ineffective. Vaborbactam helps protect meropenem from degradation by these enzymes, enhancing its effectiveness.

How should this medicine be used?

Vabomere (meropenem-vaborbactam) is typically administered as an intravenous (IV) infusion, and it is usually given by a healthcare professional in a hospital or clinical setting. Here are general guidelines on how Vabomere is typically used:

  • Dosage and Administration: The specific dosage of Vabomere and the duration of treatment will be determined by your healthcare provider based on the type and severity of the infection, as well as your individual medical condition. Vabomere is usually administered by IV infusion over a specific period. The infusion time can vary, but it is typically given over a 3-hour period.
  • Frequency of Administration: The frequency of Vabomere administration will be determined by your healthcare provider. It may be given multiple times per day, depending on the severity of the infection.
  • Duration of Treatment: The duration of treatment with Vabomere will depend on the type and severity of the infection. It’s essential to complete the full course of treatment as prescribed by your healthcare provider, even if symptoms improve before the medication is finished.
  • Administration by Healthcare Professionals: Vabomere is administered by healthcare professionals who are trained in IV medication administration. It is not typically self-administered by patients.
  • Monitoring: Your healthcare provider will monitor your response to Vabomere during the course of treatment. This may include periodic blood tests and assessments of your overall health.
  • Missed Dose: If you miss a dose, it’s important to contact your healthcare provider promptly. They will provide guidance on how to proceed.
  • Side Effects and Adverse Reactions: Be aware of potential side effects or adverse reactions, and promptly report any unusual or severe symptoms to your healthcare provider.

It’s crucial to follow your healthcare provider’s instructions precisely and to communicate any concerns or questions you may have about the medication. Additionally, inform your healthcare provider about any other medications, supplements, or medical conditions you have, as they can affect the safety and effectiveness of Vabomere.

Other uses for this medicine

Vabomere (meropenem-vaborbactam) is specifically indicated for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis, in adults. It is not approved for other uses, and its safety and efficacy for conditions other than cUTI have not been established.

What special precautions should I follow?

Special precautions should be taken when using Vabomere, and it’s essential to follow your healthcare provider’s advice and instructions. Here are some general precautions associated with the use of Vabomere:

  • Allergies: Inform your healthcare provider about any known allergies to antibiotics, especially beta-lactams (e.g., penicillins, cephalosporins), or any other components of Vabomere.
  • Kidney Function: Vabomere is primarily eliminated through the kidneys. If you have impaired kidney function, your healthcare provider may need to adjust the dosage accordingly.
  • Seizure Risk: Carbapenem antibiotics, including meropenem in Vabomere, have been associated with an increased risk of seizures. Inform your healthcare provider if you have a history of seizures or other neurological conditions.
  • Clostridium difficile Infection: Antibiotic use, including Vabomere, may increase the risk of Clostridium difficile infection, which can cause severe diarrhea. Inform your healthcare provider if you develop persistent diarrhea during or after treatment.
  • Drug Interactions: Inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some medications may interact with Vabomere.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Vabomere during pregnancy and breastfeeding is not well-established, and your healthcare provider will weigh the potential risks and benefits.
  • Incomplete Treatment: It is crucial to complete the full course of treatment as prescribed by your healthcare provider, even if you start feeling better before the medication is finished. Incomplete treatment may lead to the development of antibiotic-resistant bacteria.
  • Superinfections: The use of antibiotics can sometimes result in the overgrowth of non-susceptible organisms, leading to secondary infections. If you notice new or worsening symptoms during or after treatment, contact your healthcare provider.

Always follow your healthcare provider’s recommendations and report any unusual or severe side effects promptly. If you have specific concerns or questions about Vabomere, discuss them with your healthcare provider for personalized guidance based on your medical history and current health status.

What special dietary instructions should I follow?

There are typically no specific dietary restrictions associated with Vabomere. However, it’s essential to maintain good overall nutrition and hydration during your course of treatment. If you have specific dietary concerns or restrictions, discuss them with your healthcare provider.

What should I do if I forget a dose?

If you forget a dose of Vabomere, contact your healthcare provider as soon as possible for guidance. It’s important not to double the dose to make up for a missed one. Your healthcare provider will provide instructions on how to proceed and may adjust the schedule or dosage as necessary.

What side effects can this medication cause?

Like any medication, Vabomere (meropenem-vaborbactam) can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Common and serious side effects associated with Vabomere include:

Common Side Effects:

  • Headache
  • Phlebitis (inflammation of a vein)
  • Diarrhea
  • Nausea
  • Infusion site reactions (pain, redness, swelling)

Serious Side Effects:

  • Allergic reactions: Serious allergic reactions, including anaphylaxis, can occur. Seek emergency medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, or severe rash.
  • Seizures: Carbapenem antibiotics, including meropenem in Vabomere, may increase the risk of seizures. Inform your healthcare provider if you have a history of seizures.
  • Clostridium difficile infection: Antibiotic use can lead to the overgrowth of C. difficile bacteria, causing severe diarrhea and colitis.
  • Decreased effectiveness of oral contraceptives: Women using hormonal contraceptives should use an additional non-hormonal method during and for one week after Vabomere treatment.

It’s essential to contact your healthcare provider if you experience any unusual or severe side effects while taking Vabomere. If you develop signs of an allergic reaction or a severe adverse event, seek medical attention immediately.

This list is not exhaustive, and there may be other side effects associated with Vabomere. Your healthcare provider can provide more detailed information based on your medical history and individual circumstances. Always follow your healthcare provider’s instructions, report any side effects promptly, and do not hesitate to seek medical attention if you have concerns about your health during treatment.

What should I know about storage and disposal of this medication?

Storage and Disposal of Vabomere:

  • Storage: Vabomere is typically stored in a healthcare setting, such as a hospital or clinic, where it is administered under the supervision of healthcare professionals. If Vabomere is prescribed for home use, your healthcare provider will provide specific instructions on storage. Follow those instructions carefully.
  • Disposal: Dispose of any unused or expired Vabomere according to local regulations and guidelines. Do not dispose of medications in wastewater or household waste unless specifically instructed to do so.

In case of emergency/overdose

  • In case of an emergency or overdose, contact your local poison control center (1-800-222-1222 in the United States) or seek emergency medical attention immediately.
  • Overdose symptoms may include seizures, confusion, and decreased consciousness.

What other information should I know?

  • Follow Healthcare Provider’s Instructions: Always take Vabomere exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your healthcare provider.
  • Complete the Full Course: Finish the full course of treatment, even if you start feeling better before the medication is finished. Incomplete treatment may result in the development of antibiotic-resistant bacteria.
  • Inform Healthcare Provider: Inform your healthcare provider about all medications you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Vabomere during pregnancy and breastfeeding is not well-established.
  • Allergic Reactions: Be aware of signs of allergic reactions, such as difficulty breathing, swelling of the face or throat, or severe rash. Seek medical attention immediately if you experience these symptoms.
  • Side Effects: Report any side effects or unusual symptoms to your healthcare provider promptly.
  • Contraception: If you are a woman using hormonal contraceptives, use an additional non-hormonal method during and for one week after Vabomere treatment.

Always consult with your healthcare provider for personalized advice and information based on your individual health status and medical history. If you have specific questions or concerns about Vabomere, your healthcare provider is the best source of information.

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