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Why is this medication prescribed?

Trofinetide is a medication primarily prescribed for the treatment of Rett syndrome, a rare genetic neurological disorder that affects mainly females. Rett syndrome is characterized by severe impairments in cognitive, motor, sensory, and autonomic function. Trofinetide works by targeting certain pathways in the brain associated with Rett syndrome, potentially improving symptoms and quality of life for individuals with the condition.

How should this medicine be used?

Trofinetide is typically administered via subcutaneous injection, which means it is injected under the skin. The specific dosage and administration schedule will be determined by a healthcare professional based on factors such as the patient’s age, weight, and the severity of their condition.

Here are general guidelines for using Trofinetide:

  • Preparation: Wash your hands thoroughly with soap and water. Gather all the necessary supplies, including Trofinetide vials, syringes, alcohol swabs, and a sharps disposal container.
  • Injection Site: Choose an appropriate injection site, typically on the abdomen or thigh. Rotate injection sites to prevent irritation or tissue damage.
  • Vial Preparation: If the medication is provided as a powder, you’ll need to reconstitute it with a diluent provided by the manufacturer. Follow the instructions provided carefully for reconstitution.
  • Drawing the Medication: Use a sterile syringe to draw up the prescribed dosage of Trofinetide from the vial. Make sure to remove any air bubbles from the syringe.
  • Injection: Clean the chosen injection site with an alcohol swab and allow it to dry. Pinch a fold of skin and fat between your fingers to create a small area for injection. Insert the needle at a 45 to 90-degree angle and inject the medication slowly.
  • Disposal: Dispose of needles and syringes in a sharps disposal container as instructed by your healthcare provider or local regulations.
  • Storage: Store Trofinetide vials and any reconstituted solution according to the manufacturer’s instructions. Keep them out of reach of children and pets.

It’s crucial to follow the instructions provided by your healthcare provider and undergo proper training on how to administer Trofinetide safely and effectively. If you have any questions or concerns about the administration process, be sure to consult your healthcare provider for guidance.

Other uses for this medicine

  • There are no other approved uses for Trofinetide as of last update. Always follow your healthcare provider’s instructions and the directions on the product label regarding the appropriate use of Trofinetide.

What special precautions should I follow?

Regarding special precautions for Trofinetide, it’s essential to follow the guidance provided by your healthcare provider. Here are some general precautions to consider:

  • Allergies: Inform your healthcare provider if you have any known allergies to Trofinetide or any of its components. This medication may contain inactive ingredients that can cause allergic reactions or other problems.
  • Medical History: Provide your healthcare provider with a comprehensive medical history, including any pre-existing conditions, such as kidney or liver problems, that may affect the use of Trofinetide.
  • Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, discuss the potential risks and benefits of using Trofinetide with your healthcare provider. It’s essential to weigh the potential benefits to the mother against any possible risks to the fetus or infant.
  • Drug Interactions: Inform your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking, as Trofinetide may interact with certain drugs. This includes vitamins and supplements.
  • Injection Safety: If you are administering Trofinetide through subcutaneous injection at home, ensure that you receive proper training from a healthcare professional on how to administer the medication safely. Follow all instructions for storage, handling, and disposal of needles and syringes.
  • Monitoring: Your healthcare provider may need to monitor your progress regularly while you are taking Trofinetide to ensure that it is working effectively and to detect any potential side effects.
  • Adverse Reactions: Be aware of any potential side effects or adverse reactions associated with Trofinetide and report them to your healthcare provider promptly. These may include injection site reactions, allergic reactions, or changes in mood or behavior.

Always consult your healthcare provider for personalized advice and guidance regarding the use of Trofinetide, including any specific precautions or considerations based on your individual medical history and circumstances.

What special dietary instructions should I follow?

There are no specific special dietary instructions associated with the use of Trofinetide. However, it’s essential to follow your healthcare provider’s advice regarding diet and nutrition, especially if you have any underlying medical conditions that require dietary restrictions or modifications.

What should I do if I forget a dose?

If you forget a dose of Trofinetide, it’s important to contact your healthcare provider or pharmacist for guidance on what to do next. They may advise you on whether to take the missed dose as soon as you remember or to skip it and continue with your regular dosing schedule. It’s essential not to double the dose to make up for a missed one unless instructed to do so by your healthcare provider. Consistent adherence to the prescribed dosing schedule is crucial for optimal treatment outcomes.

What side effects can this medication cause?

Trofinetide is a drug that has been investigated for the treatment of various neurodevelopmental disorders, particularly Rett syndrome. As of last update, Trofinetide is still under clinical investigation, and its side effects may vary based on ongoing clinical trials and research.

However, some common side effects reported in clinical trials of Trofinetide for Rett syndrome include:

  • Gastrointestinal disturbances: This may include symptoms such as diarrhea, constipation, nausea, vomiting, and abdominal pain.
  • Fatigue: Some individuals may experience increased fatigue or tiredness while taking Trofinetide.
  • Upper respiratory tract infections: There have been reports of increased susceptibility to respiratory infections such as colds and flu-like symptoms.
  • Sleep disturbances: Changes in sleep patterns, including difficulty falling asleep or staying asleep, have been reported in some individuals.
  • Headache: Headaches are a relatively common side effect reported in clinical trials of Trofinetide.
  • Irritability: Some individuals may experience increased irritability or mood changes while taking Trofinetide.

It’s important to note that the side effects of Trofinetide can vary from person to person, and not everyone will experience the same side effects. Additionally, ongoing clinical trials may provide more information about the safety profile of Trofinetide and any additional side effects that may emerge. Always consult with a healthcare professional for personalized medical advice and information about potential side effects associated with any medication.

What should I know about storage and disposal of this medication?

Storage and disposal of Trofinetide:


  • Follow the storage instructions provided by your healthcare provider or pharmacist. Trofinetide may require refrigeration or storage at room temperature, depending on the formulation.
  • Keep Trofinetide out of reach of children and pets.
  • Store Trofinetide away from direct sunlight, heat, and moisture.
  • Do not freeze Trofinetide unless instructed otherwise.


  • Dispose of any unused or expired Trofinetide according to local regulations or guidelines.
  • If you are administering Trofinetide injections at home, dispose of needles, syringes, and any unused medication in a sharps disposal container. Do not throw them in the household trash.

In case of emergency/overdose

  • In case of an emergency or suspected overdose, seek immediate medical attention or contact your local poison control center.
  • Provide healthcare professionals with information about the medication, dosage, and timing of ingestion.

What other information should I know?

  • Keep all appointments with your healthcare provider for monitoring and follow-up while taking Trofinetide.
  • Inform all healthcare providers involved in your care about your use of Trofinetide, including dentists and specialists.
  • Do not share Trofinetide with others, even if they have similar symptoms or conditions.
  • Follow your healthcare provider’s instructions carefully regarding dosing, administration, and any necessary precautions.
  • Report any new or worsening symptoms, side effects, or concerns to your healthcare provider promptly.
  • It’s essential to have a comprehensive understanding of your treatment plan, including the goals of therapy and potential benefits and risks of Trofinetide.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about the storage, disposal, administration, or potential side effects of Trofinetide. They can provide you with personalized guidance and support to ensure the safe and effective use of this medication.

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