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Triderm (Generic Triamcinolone Topical)

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Why is this medication prescribed?

Triderm is prescribed for the treatment of various skin conditions, particularly those involving inflammation, infection, or both. It contains three active ingredients:

  • Betamethasone: This is a corticosteroid medication that helps reduce inflammation and itching associated with various skin conditions such as eczema, dermatitis, psoriasis, and allergic reactions.
  • Clotrimazole: This is an antifungal medication used to treat fungal infections of the skin, including athlete’s foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis).
  • Gentamicin: This is an antibiotic medication that works by stopping the growth of bacteria. It is used to treat bacterial infections of the skin, including those caused by Staphylococcus aureus and other bacteria susceptible to gentamicin.

Triderm is often prescribed when there is a combination of inflammation, fungal infection, and bacterial infection present on the skin. This combination medication can help address multiple aspects of the skin condition simultaneously, providing relief from symptoms and promoting healing.

Common conditions for which Triderm may be prescribed include eczema with secondary bacterial or fungal infections, dermatitis complicated by infection, and other inflammatory skin disorders where bacterial or fungal infection is present or likely to occur.

How should this medicine be used?

Here’s how Triderm should be used:

  • Clean and dry the affected area: Before applying Triderm, wash the affected area with mild soap and water, and pat it dry gently.
  • Apply a thin layer: Apply a thin layer of Triderm cream or ointment to the affected area and gently rub it in. Be sure to cover the entire affected area with a thin film of the medication.
  • Frequency of application: The frequency of application will depend on the severity of the condition and your doctor’s instructions. Typically, Triderm is applied two to three times daily.
  • Duration of use: Follow your doctor’s instructions regarding the duration of use. It’s essential not to use Triderm for longer than prescribed, as prolonged use of corticosteroids can lead to adverse effects.
  • Avoid covering the treated area unless instructed: Unless directed by your doctor, avoid covering the treated area with bandages or dressings, as this may increase the absorption of the medication and the risk of side effects.
  • Wash hands after application: After applying Triderm, wash your hands thoroughly to avoid inadvertently spreading the medication to other areas of the body or transferring it to others.
  • Monitor for side effects: Be vigilant for any signs of adverse reactions, such as irritation, burning, itching, or redness at the application site. If you experience any concerning side effects, contact your doctor promptly.
  • Do not use on broken or infected skin: Avoid using Triderm on broken or infected skin unless specifically directed by your doctor, as it may exacerbate the condition or lead to systemic absorption of the antibiotic component.

Always follow your doctor’s instructions and read the patient information leaflet provided with the medication for specific guidance on how to use Triderm correctly. If you have any questions or concerns about the use of Triderm, don’t hesitate to consult your healthcare provider.

Other uses for this medicine

Triderm is primarily used for the treatment of various skin conditions involving inflammation, fungal infections, and bacterial infections, as described earlier. However, it’s essential to note that its use should be limited to conditions for which it has been specifically prescribed by a healthcare professional.

What special precautions should I follow?

As for special precautions to follow when using Triderm:

  • Use as directed: Use Triderm exactly as prescribed by your healthcare provider. Follow the dosage instructions, frequency of application, and duration of treatment as recommended.
  • Avoid prolonged use: Prolonged use of corticosteroids like betamethasone can lead to adverse effects, including skin thinning, stretch marks, and increased susceptibility to infections. Follow your doctor’s instructions regarding the duration of Triderm use.
  • Avoid contact with eyes and mucous membranes: Avoid getting Triderm cream or ointment in your eyes or mucous membranes (such as inside your nose, mouth, or genital area). If accidental contact occurs, rinse thoroughly with water.
  • Do not use on broken or infected skin without medical supervision: While Triderm contains an antibiotic (gentamicin) for bacterial infections, it should not be used on open wounds, broken skin, or infected areas without medical supervision. Doing so may lead to systemic absorption of the antibiotic and potential adverse effects.
  • Monitor for adverse effects: Pay attention to any signs of skin irritation, allergic reactions, or worsening of symptoms while using Triderm. If you experience significant discomfort or adverse effects, consult your healthcare provider.
  • Avoid abrupt discontinuation: If your doctor has prescribed Triderm for a specific duration, do not discontinue its use abruptly unless instructed to do so by your healthcare provider. Abrupt discontinuation of corticosteroids can lead to withdrawal symptoms and flare-ups of the underlying skin condition.
  • Inform your healthcare provider about other medications: Inform your doctor about any other medications, supplements, or topical treatments you are using, as they may interact with Triderm or affect its efficacy.
  • Keep out of reach of children: Store Triderm out of reach of children and pets, and avoid accidental ingestion.

Always consult your healthcare provider for specific guidance and precautions related to the use of Triderm, especially if you have underlying health conditions or are taking other medications.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are typically no specific dietary restrictions associated with the use of Triderm. However, it’s always a good idea to maintain a balanced diet and stay hydrated to support overall skin health and healing.

What should I do if I forget a dose?

If you forget a dose of Triderm, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream or ointment to make up for the missed dose. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Triderm, like any medication, can cause side effects, although not everyone experiences them. Common side effects of Triderm may include:

  • Skin irritation: This may include burning, itching, redness, or stinging at the site of application.
  • Skin thinning: Prolonged use of corticosteroids like betamethasone can lead to thinning of the skin, particularly in areas where the medication is applied frequently or for extended periods.
  • Stretch marks: Long-term use of corticosteroids may increase the risk of developing stretch marks, especially in areas of the body where the skin is thin (such as the face, groin, and armpits).
  • Acne or worsening of acne: Corticosteroids can sometimes trigger or worsen acne in some individuals.
  • Hypersensitivity reactions: Rarely, individuals may experience allergic reactions to one or more of the components of Triderm, leading to symptoms such as rash, hives, swelling, or difficulty breathing.
  • Folliculitis: Inflammation or infection of hair follicles may occur, particularly if Triderm is used on hairy areas of the body.
  • Skin discoloration: Prolonged use of corticosteroids may lead to changes in skin pigmentation, such as lightening or darkening of the skin.
  • Increased hair growth: Some individuals may experience increased hair growth in the area where Triderm is applied.
  • Bacterial or fungal overgrowth: Prolonged use of corticosteroids and antibiotics can lead to overgrowth of bacteria or fungi on the skin, resulting in secondary infections.

It’s important to note that the likelihood and severity of side effects can vary from person to person and depend on factors such as the duration of treatment, the area of application, and individual susceptibility. If you experience any concerning side effects while using Triderm, contact your healthcare provider for further guidance. Additionally, always read the patient information leaflet provided with the medication for a comprehensive list of potential side effects and safety information.

What should I know about storage and disposal of this medication?

Storage and Disposal:


  • Store Triderm at room temperature away from light and moisture.
  • Keep the medication out of reach of children and pets.
  • Do not freeze Triderm.


  • Dispose of Triderm properly according to local regulations or as directed by your healthcare provider or pharmacist.
  • Do not flush medications down the toilet unless instructed to do so.
  • If you have any unused or expired Triderm, consult your pharmacist or healthcare provider for guidance on proper disposal.

In case of emergency/overdose

In case of emergency or overdose of Triderm, take the following steps:

  • In case of an overdose or accidental ingestion of Triderm, contact your local poison control center or seek emergency medical attention immediately.
  • Overdose of topical corticosteroids like Triderm can lead to symptoms such as skin thinning, increased blood pressure, fluid retention, and electrolyte imbalance.
  • If possible, bring the Triderm packaging or container with you to the emergency room to assist healthcare providers in treatment.

What other information should I know?

  • Inform your healthcare provider about any other medications, supplements, or topical treatments you are using, as they may interact with Triderm.
  • Avoid exposure to sunlight or artificial UV rays (e.g., tanning beds) while using Triderm, as corticosteroids can increase sensitivity to sunlight and increase the risk of sunburn.
  • Do not use Triderm for conditions other than those for which it has been prescribed.
  • Follow your doctor’s instructions regarding the duration of treatment with Triderm. Prolonged or excessive use can lead to adverse effects.
  • Keep all appointments with your healthcare provider for follow-up evaluations while using Triderm.
  • If you have any questions or concerns about Triderm or its use, consult your healthcare provider or pharmacist for guidance.

It’s important to adhere to these guidelines to ensure the safe and effective use of Triderm and to minimize the risk of adverse effects or complications.

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