PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Triamterene and Hydrochlorothiazide

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Triamterene and hydrochlorothiazide are medications commonly prescribed together for the treatment of hypertension (high blood pressure) and edema (fluid retention) caused by various conditions such as congestive heart failure, liver cirrhosis, or kidney disorders. They belong to a class of drugs known as diuretics or “water pills,” which work by increasing the amount of urine produced by the kidneys, thereby helping to remove excess water and salt from the body.

Triamterene works by directly blocking the reabsorption of sodium in the kidneys, while hydrochlorothiazide enhances the excretion of sodium and water by the kidneys by inhibiting sodium reabsorption in the distal convoluted tubule.

How should this medicine be used?

Here’s how Triamterene and Hydrochlorothiazide are typically used:

  • Dosage: The dosage of Triamterene and Hydrochlorothiazide will depend on various factors such as the patient’s age, medical condition, and response to treatment. It’s important to follow the dosage instructions provided by the healthcare provider or pharmacist carefully.
  • Administration: These medications are usually taken orally, with or without food, as directed by the healthcare provider. It’s essential to take them exactly as prescribed. Do not take more or less than the prescribed dose, and do not stop taking them without consulting your doctor, even if you feel well.
  • Timing: Typically, Triamterene and Hydrochlorothiazide are taken once or twice daily. It’s important to take them at the same time(s) each day to maintain a consistent level of the medication in the body.
  • Follow-up: Regular follow-up appointments with the healthcare provider are essential to monitor blood pressure, electrolyte levels, and kidney function while taking Triamterene and Hydrochlorothiazide.
  • Avoiding certain substances: While taking these medications, it’s important to avoid excessive consumption of potassium-rich foods or supplements, as Triamterene can cause hyperkalemia (high potassium levels). Additionally, it’s important to stay adequately hydrated, especially in hot weather or during vigorous exercise, to prevent dehydration and electrolyte imbalances.
  • Potential side effects: Like all medications, Triamterene and Hydrochlorothiazide can cause side effects, including dizziness, headache, nausea, weakness, electrolyte imbalances, and changes in blood sugar levels. If you experience any concerning side effects, contact your healthcare provider.

It’s crucial to communicate with your healthcare provider about any concerns or questions you may have regarding the use of Triamterene and Hydrochlorothiazide. They can provide personalized guidance based on your individual medical history and needs.

Other uses for this medicine

Some potential off-label uses include:

  • Management of certain types of kidney stones: Triamterene may help prevent the formation of certain types of kidney stones by reducing the amount of calcium excreted in the urine.
  • Treatment of Meniere’s disease: Triamterene may be used in some cases to reduce fluid retention in the inner ear, which can help alleviate symptoms of Meniere’s disease, such as vertigo and dizziness.
  • Hypokalemia (low potassium levels): Triamterene, in combination with hydrochlorothiazide, may be used to help correct low potassium levels in the body, as it can spare potassium loss caused by hydrochlorothiazide.
  • Polycystic ovarian syndrome (PCOS): Some healthcare providers may prescribe Triamterene and hydrochlorothiazide off-label to manage symptoms associated with PCOS, such as fluid retention and hypertension.

What special precautions should I follow?

As for special precautions for Triamterene and Hydrochlorothiazide, there are several key considerations:

  • Allergies: Before taking Triamterene and Hydrochlorothiazide, inform your healthcare provider if you have any allergies to sulfa drugs or any other medications.
  • Medical history: Discuss your medical history with your healthcare provider, especially if you have a history of kidney problems, liver disease, gout, diabetes, or lupus. These conditions may affect the safety and effectiveness of Triamterene and Hydrochlorothiazide.
  • Pregnancy and breastfeeding: Triamterene and Hydrochlorothiazide are generally not recommended during pregnancy, especially during the second and third trimesters, as they may harm the fetus. They may also pass into breast milk and could harm a nursing infant. Discuss the risks and benefits with your healthcare provider if you are pregnant or breastfeeding.
  • Electrolyte imbalances: Triamterene and Hydrochlorothiazide can cause electrolyte imbalances, particularly low potassium levels (hypokalemia) or high potassium levels (hyperkalemia). Your healthcare provider may monitor your electrolyte levels periodically while you are taking these medications.
  • Interaction with other medications: Triamterene and Hydrochlorothiazide may interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), lithium, digoxin, certain blood pressure medications, and corticosteroids. Inform your healthcare provider about all the medications you are taking to avoid potential interactions.
  • Dehydration: Triamterene and Hydrochlorothiazide can increase urination, leading to dehydration, especially in hot weather or during vigorous exercise. Drink plenty of fluids and avoid excessive sweating to prevent dehydration.

Always follow your healthcare provider’s instructions and guidance regarding the use of Triamterene and Hydrochlorothiazide, and do not hesitate to ask questions or seek clarification about any concerns you may have.

What special dietary instructions should I follow?

As for special dietary instructions:

  • Potassium-Rich Foods: Since Triamterene can increase potassium levels, it’s advisable to avoid excessive consumption of potassium-rich foods such as bananas, oranges, tomatoes, potatoes, spinach, and certain nuts.
  • Salt Intake: Depending on your condition, your healthcare provider may recommend reducing your salt intake to help control blood pressure and fluid retention.

What should I do if I forget a dose?

If you miss a dose of Triamterene and Hydrochlorothiazide, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance. It’s important to maintain a consistent dosing schedule to ensure the effectiveness of the medication in controlling your blood pressure and managing fluid retention.

What side effects can this medication cause?

Triamterene and hydrochlorothiazide, like any medication, can potentially cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of Triamterene and hydrochlorothiazide may include:

  • Dizziness or lightheadedness
  • Headache
  • Nausea or vomiting
  • Weakness or fatigue
  • Dry mouth
  • Increased sensitivity to sunlight (photosensitivity)
  • Muscle cramps or weakness
  • Electrolyte imbalances, including low sodium (hyponatremia) or high potassium (hyperkalemia) levels
  • Increased urination
  • Changes in blood sugar levels

It’s important to note that some side effects, such as electrolyte imbalances, may be more serious and require medical attention. Additionally, there may be other, less common side effects not listed here. If you experience any concerning or persistent side effects while taking Triamterene and hydrochlorothiazide, contact your healthcare provider for further evaluation and guidance.

In rare cases, Triamterene and hydrochlorothiazide may cause more severe side effects, including:

  • Allergic reactions such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
  • Severe skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis, which are rare but potentially life-threatening. These conditions typically manifest as severe skin blistering, rash, and skin peeling.
  • Blood disorders such as thrombocytopenia (low platelet count) or agranulocytosis (severe reduction in white blood cell count), which can increase the risk of bleeding or infections.
  • Liver problems, including hepatitis or liver failure, which may present with symptoms such as yellowing of the skin or eyes, dark urine, or persistent abdominal pain.

It’s important to report any unusual or severe symptoms to your healthcare provider promptly. They can evaluate your symptoms and determine whether any adjustments to your treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage and disposal of Triamterene and Hydrochlorothiazide:


  • Store Triamterene and Hydrochlorothiazide at room temperature, away from moisture, heat, and light.
  • Keep the medication in its original container or packaging, tightly closed, and out of reach of children and pets.
  • Do not store Triamterene and Hydrochlorothiazide in the bathroom or near the kitchen sink, where it could be exposed to moisture and humidity.
  • Avoid storing the medication in extreme temperatures, such as in the freezer or in direct sunlight.


  • If you have unused or expired Triamterene and Hydrochlorothiazide, dispose of it properly according to local regulations or guidelines.
  • Do not flush medications down the toilet or pour them down the drain unless instructed to do so by your healthcare provider or pharmacist.
  • Contact your local pharmacy or waste disposal facility to inquire about proper medication disposal methods in your area.

In case of emergency/overdose

In case of emergency or overdose of Triamterene and Hydrochlorothiazide:

  • If you suspect an overdose of Triamterene and Hydrochlorothiazide or experience severe symptoms such as fainting, irregular heartbeat, extreme weakness, confusion, or seizures, seek immediate medical attention or contact your local poison control center.
  • Be prepared to provide information about the medication taken, including the dosage and time of ingestion, to healthcare providers or emergency responders.
  • Do not attempt to induce vomiting unless instructed to do so by medical professionals.

What other information should I know?

  • Keep all appointments with your healthcare provider for regular monitoring of blood pressure, kidney function, and electrolyte levels while taking Triamterene and Hydrochlorothiazide.
  • Inform all healthcare providers involved in your care, including dentists and specialists, about your use of Triamterene and Hydrochlorothiazide.
  • Carry a list of all medications you are taking, including prescription and over-the-counter drugs, herbal supplements, and vitamins, and show it to healthcare providers during medical appointments or emergencies.
  • Avoid alcohol consumption while taking Triamterene and Hydrochlorothiazide, as it can exacerbate side effects such as dizziness or drowsiness.
  • Do not share Triamterene and Hydrochlorothiazide with others, even if they have similar symptoms or conditions, as it may not be safe or effective for them.

By following these guidelines and being informed about the proper storage, disposal, and emergency procedures for Triamterene and Hydrochlorothiazide, you can help ensure the safe and effective use of this medication.

Copyright © 2023