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Trialodine (Generic Trazodone)

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Trialodine, also known as trihexyphenidyl, is a medication primarily used to treat symptoms of Parkinson’s disease and certain movement disorders. While it can be effective in managing these conditions, there are several potential risks associated with its use:

  • Side Effects: Common side effects of Trialodine may include dry mouth, blurred vision, constipation, urinary retention, and dizziness. These side effects can impair daily functioning and reduce quality of life for some individuals.
  • Central Nervous System Effects: Trialodine can cause various central nervous system effects, such as confusion, hallucinations, agitation, and delirium, particularly in elderly patients. These effects can be concerning, especially in individuals with preexisting cognitive impairment.
  • Cardiovascular Effects: There is a risk of cardiovascular side effects with Trialodine, including tachycardia (rapid heartbeat), palpitations, and arrhythmias. Patients with a history of cardiovascular disease should be closely monitored when taking this medication.
  • Heat Intolerance: Trialodine can interfere with the body’s ability to regulate temperature, leading to heat intolerance and an increased risk of heat stroke, especially in hot weather or during physical activity.
  • Interaction with Other Medications: Trialodine may interact with other medications, including certain antipsychotics, antidepressants, and antihistamines, potentially leading to adverse effects or reduced efficacy of either medication.
  • Risk of Abuse: There is a potential for Trialodine to be abused, particularly in individuals seeking its anticholinergic effects for recreational purposes. Abuse of Trialodine can lead to dependence, tolerance, and serious health consequences.
  • Contraindications: Trialodine is contraindicated in individuals with a history of hypersensitivity to the drug, narrow-angle glaucoma, and certain gastrointestinal conditions like paralytic ileus. It should be used cautiously in patients with conditions such as prostatic hypertrophy, urinary retention, and myasthenia gravis.
  • Withdrawal Symptoms: Abrupt discontinuation of Trialodine can lead to withdrawal symptoms such as nausea, vomiting, sweating, anxiety, and tremors. Tapering off the medication under medical supervision is usually recommended to minimize these effects.

It’s important for individuals prescribed Trialodine to be aware of these potential risks and to discuss any concerns with their healthcare provider. Close monitoring and adherence to prescribed dosages can help mitigate some of these risks while maximizing the benefits of treatment.

Why is this medication prescribed?

Trialodine, also known as trihexyphenidyl, is prescribed for several medical conditions, primarily to alleviate symptoms associated with movement disorders such as Parkinson’s disease and extrapyramidal side effects caused by certain medications, particularly antipsychotics. Here’s why it’s prescribed for these conditions:

  • Parkinson’s Disease: Trialodine is used to help manage the symptoms of Parkinson’s disease, including tremors, muscle stiffness, and involuntary movements. It works by blocking acetylcholine receptors in the brain, thereby helping to restore the balance of neurotransmitters involved in motor control.
  • Extrapyramidal Side Effects: Some antipsychotic medications can cause extrapyramidal symptoms such as dystonia, akathisia, and Parkinsonism. Trialodine may be prescribed alongside these antipsychotics to reduce or alleviate these side effects, improving the tolerability of the antipsychotic treatment.

How should this medicine be used?

As for how Trialodine should be used, it’s essential to follow the prescribing physician’s instructions carefully. Here are some general guidelines:

  • Dosage: The dosage of Trialodine varies depending on the individual’s condition, age, and response to treatment. It’s typically started at a low dose and gradually increased as necessary under medical supervision.
  • Administration: Trialodine is usually taken orally in the form of tablets or capsules. It can be taken with or without food, but consistency in administration (either always with food or always without food) is recommended.
  • Frequency: The medication is typically taken multiple times per day to maintain therapeutic levels in the body. The exact dosing frequency will depend on the individual’s condition and the formulation of the medication.
  • Duration: Trialodine is often used as a long-term treatment for chronic conditions like Parkinson’s disease. It’s essential to continue taking the medication as prescribed, even if symptoms improve, unless instructed otherwise by a healthcare professional.
  • Monitoring: Regular follow-up appointments with the prescribing physician are important to monitor the effectiveness of Trialodine and to adjust the dosage as needed. It’s crucial to report any side effects or concerns during these appointments.
  • Discontinuation: If discontinuation of Trialodine is necessary, it should be done gradually under medical supervision to minimize the risk of withdrawal symptoms.

Overall, adherence to the prescribed dosage and regimen, along with open communication with healthcare providers, is key to maximizing the benefits of Trialodine while minimizing the risk of adverse effects.

Other uses for this medicine

In addition to its primary use in managing Parkinson’s disease and extrapyramidal side effects, Trialodine may have off-label uses in certain medical conditions. These off-label uses include:

  • Dystonia: Trialodine may be used to alleviate symptoms of dystonia, a movement disorder characterized by sustained muscle contractions that cause repetitive or twisting movements and abnormal postures.
  • Tardive Dyskinesia: This condition involves involuntary movements, typically of the face and tongue, that can occur as a side effect of long-term use of certain medications, particularly antipsychotics. Trialodine may be prescribed to help manage these symptoms.
  • Hyperhidrosis: Some individuals may experience excessive sweating (hyperhidrosis), particularly in specific areas of the body. Trialodine’s anticholinergic properties can help reduce sweating in these cases.

What special precautions should I follow?

Regarding special precautions for Trialodine, here are some important considerations:

  • Medical History: Before starting Trialodine, inform your healthcare provider about any medical conditions you have, especially glaucoma, urinary retention, gastrointestinal disorders, heart disease, or psychiatric disorders.
  • Allergies: If you have a known allergy to Trialodine or any of its ingredients, inform your doctor. Allergic reactions can range from mild to severe and may require immediate medical attention.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Trialodine during pregnancy and breastfeeding has not been well studied, and its use in these situations should be carefully considered.
  • Driving and Operating Machinery: Trialodine can cause dizziness, blurred vision, and other central nervous system effects that may impair your ability to drive or operate machinery safely. Use caution when engaging in activities that require mental alertness until you know how Trialodine affects you.
  • Alcohol and Sedatives: Trialodine can enhance the sedative effects of alcohol and other central nervous system depressants. Avoid consuming alcohol or taking sedatives while on Trialodine unless directed otherwise by your healthcare provider.
  • Heat Exposure: Trialodine can impair the body’s ability to regulate temperature, increasing the risk of heat-related illnesses. Avoid prolonged exposure to high temperatures and take precautions to stay hydrated in hot environments.
  • Interaction with Other Medications: Trialodine may interact with other medications, including certain antipsychotics, antidepressants, antihistamines, and medications that affect heart rhythm. Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.

By being aware of these precautions and discussing any concerns with your healthcare provider, you can help ensure the safe and effective use of Trialodine for your condition.

What special dietary instructions should I follow?

Special dietary instructions for Trialodine are generally not required. However, it’s essential to maintain a balanced diet and stay hydrated, especially if Trialodine causes dry mouth or constipation.

What should I do if I forget a dose?

If you forget a dose of Trialodine, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance. Consistency in taking Trialodine as prescribed is important for maintaining therapeutic levels in your body.

What side effects can this medication cause?

Trialodine, also known as trihexyphenidyl, can cause several side effects, ranging from mild to severe. Common side effects include:

  • Dry Mouth: This is one of the most common side effects of Trialodine. It can be bothersome but is usually not serious. Drinking water or sucking on sugar-free candy can help alleviate dry mouth.
  • Blurred Vision: Trialodine can cause blurred vision, making it difficult to see clearly. This effect may improve over time as your body adjusts to the medication.
  • Constipation: Some individuals may experience constipation while taking Trialodine. Increasing fiber intake and staying hydrated can help manage this side effect.
  • Urinary Retention: Trialodine can cause difficulty urinating or urinary retention in some individuals. If you experience this side effect, contact your healthcare provider.
  • Dizziness: Trialodine may cause dizziness, especially when standing up quickly or moving suddenly. Take caution when engaging in activities that require balance and coordination.
  • Confusion: Some individuals may experience confusion or cognitive impairment while taking Trialodine, particularly at higher doses or in elderly patients.
  • Hallucinations: In some cases, Trialodine can cause hallucinations or delusions, particularly in susceptible individuals or at higher doses.
  • Agitation: Trialodine may lead to increased agitation or restlessness, particularly in individuals with a history of psychiatric disorders.
  • Tachycardia: Rapid heartbeat or palpitations can occur as a side effect of Trialodine, especially in individuals with underlying heart conditions.
  • Sweating: Trialodine can cause increased sweating, particularly in hot environments or during physical activity.

It’s important to note that not everyone will experience these side effects, and the severity and frequency of side effects can vary from person to person. If you experience any concerning or bothersome side effects while taking Trialodine, contact your healthcare provider for further evaluation and guidance. Additionally, if you experience severe side effects such as difficulty breathing, chest pain, or severe allergic reactions, seek immediate medical attention.

What should I know about storage and disposal of this medication?

Storage and Disposal:


  • Store Trialodine at room temperature, away from moisture, heat, and light.
  • Keep Trialodine in its original container with the lid tightly closed.
  • Store Trialodine out of reach of children and pets to prevent accidental ingestion.


  • Dispose of expired or unused Trialodine properly according to local guidelines or regulations.
  • Do not flush Trialodine down the toilet or pour it down the drain unless instructed to do so.
  • Consult your healthcare provider, pharmacist, or local waste disposal facility for proper disposal instructions.

In case of emergency/overdose

  • In case of emergency or overdose, call your local emergency services or poison control center immediately.
  • Symptoms of Trialodine overdose may include confusion, hallucinations, seizures, difficulty breathing, rapid heartbeat, and coma.
  • Be prepared to provide information about the amount of Trialodine ingested and any symptoms experienced.

What other information should I know?

  • Inform all healthcare providers involved in your care that you are taking Trialodine, including dentists and pharmacists.
  • Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to Trialodine and adjust your treatment plan as needed.
  • Avoid sudden discontinuation of Trialodine without consulting your healthcare provider, as this can lead to withdrawal symptoms.
  • Keep a list of all medications, supplements, and herbal products you are taking and share it with your healthcare provider to avoid potential drug interactions.
  • Be aware of the potential side effects of Trialodine and report any new or worsening symptoms to your healthcare provider promptly.

By following these guidelines and staying informed about Trialodine, you can help ensure safe and effective use of the medication for your condition.

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