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Treprostinil Oral Inhalation

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Why is this medication prescribed?

Treprostinil oral inhalation is prescribed primarily for the treatment of pulmonary arterial hypertension (PAH). PAH is a condition characterized by high blood pressure in the arteries of the lungs. Treprostinil is a prostacyclin analogue, which means it mimics the effects of prostacyclin, a natural substance in the body that helps to widen blood vessels and prevent blood clots.

By inhaling treprostinil, patients can experience vasodilation (widening of blood vessels) in the lungs, which helps to reduce blood pressure and improve blood flow. This can lead to symptom relief, such as decreased shortness of breath, increased exercise tolerance, and improved overall quality of life for individuals with PAH.

Treprostinil oral inhalation is typically prescribed when other treatments for PAH have not been effective or are not suitable for a patient’s particular condition. It is important to note that treprostinil inhalation therapy requires specialized equipment and careful administration, so it should only be used under the supervision of a healthcare professional experienced in managing PAH.

How should this medicine be used?

Treprostinil is typically used as part of a comprehensive treatment plan for PAH, which may include other medications and lifestyle changes. It is important to follow your doctor’s instructions closely when using Treprostinil Oral Inhalation. Here’s how Treprostinil Oral Inhalation is typically used:

  • Preparation: Before using Treprostinil Oral Inhalation, make sure you have read the patient information leaflet provided by your pharmacist. Also, ensure that you understand how to use the inhaler device properly.
  • Dosage: The dosage of Treprostinil Oral Inhalation will be prescribed by your doctor based on your medical condition and response to treatment. Do not change the dosage or stop using the medication without consulting your doctor first.
  • Administration: Treprostinil Oral Inhalation is usually inhaled 4 times daily during waking hours. Each inhalation session typically involves multiple breaths through the mouthpiece of the inhaler device.
  • Cleaning: After each use, it’s important to clean the inhaler device according to the instructions provided. This helps to prevent contamination and ensure proper functioning of the device.
  • Storage: Store Treprostinil Oral Inhalation at room temperature away from light and moisture. Do not store it in the bathroom. Keep it out of reach of children.
  • Missed Dose: If you miss a dose of Treprostinil Oral Inhalation, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
  • Potential Side Effects: Like all medications, Treprostinil Oral Inhalation may cause side effects. Common side effects include cough, headache, dizziness, and throat irritation. If you experience any severe side effects or any persistent side effects, contact your doctor promptly.

Always consult your healthcare provider for personalized advice regarding the use of Treprostinil Oral Inhalation and any other medications.

Other uses for this medicine

Some potential off-label uses may include:

  • Chronic Obstructive Pulmonary Disease (COPD): Treprostinil Oral Inhalation may be considered in certain cases of COPD, especially in patients with severe pulmonary hypertension associated with COPD.
  • Interstitial Lung Disease (ILD): In some cases of ILD where pulmonary hypertension is present, Treprostinil Oral Inhalation might be used to manage symptoms and improve exercise capacity.
  • Pulmonary Hypertension Secondary to Connective Tissue Diseases: Patients with connective tissue diseases such as systemic sclerosis (scleroderma) or systemic lupus erythematosus (SLE) may develop pulmonary hypertension, and Treprostinil Oral Inhalation could be considered as part of their treatment plan.

What special precautions should I follow?

Regarding special precautions for Treprostinil Oral Inhalation use, here are some important considerations:

  • Pregnancy and Breastfeeding: Treprostinil Oral Inhalation should be used during pregnancy only if clearly needed and under the direct supervision of a healthcare provider. It is not known if Treprostinil passes into breast milk, so caution is advised when using it while breastfeeding.
  • Liver and Kidney Function: Patients with impaired liver or kidney function may require dosage adjustments or closer monitoring while using Treprostinil Oral Inhalation.
  • Drug Interactions: Treprostinil may interact with other medications, including blood thinners (anticoagulants), diuretics, and certain medications metabolized by liver enzymes. It’s important to inform your doctor about all the medications you are taking, including prescription, over-the-counter, vitamins, and herbal supplements.
  • Hypotension: Treprostinil can cause low blood pressure, especially when first starting the medication or increasing the dose. Patients should be monitored for signs of hypotension and instructed on measures to prevent it, such as rising slowly from a sitting or lying position.
  • Respiratory Effects: Treprostinil Oral Inhalation may cause cough and throat irritation. Patients with pre-existing respiratory conditions should be closely monitored while using this medication.
  • Device Handling: Proper handling and cleaning of the inhaler device are essential to ensure accurate dosing and prevent contamination. Patients should be thoroughly instructed on how to use and maintain the device.

Always follow your healthcare provider’s instructions and guidance regarding the use of Treprostinil Oral Inhalation and any associated precautions.

What special dietary instructions should I follow?

Regarding special dietary instructions for Treprostinil Oral Inhalation, there are no specific dietary restrictions associated with this medication. However, maintaining a balanced and healthy diet is important for overall health, especially for individuals managing pulmonary arterial hypertension. It’s advisable to follow any dietary recommendations provided by your healthcare provider, which may include maintaining a low-sodium diet or ensuring adequate fluid intake.

What should I do if I forget a dose?

If you forget a dose of Treprostinil Oral Inhalation, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Treprostinil Oral Inhalation, like any medication, can cause side effects. Common side effects of Treprostinil Oral Inhalation may include:

  • Cough
  • Headache
  • Throat irritation
  • Nausea
  • Flushing (reddening of the skin)
  • Diarrhea
  • Jaw pain
  • Dizziness
  • Insomnia (difficulty sleeping)
  • Decreased appetite
  • Chest discomfort

These side effects are usually mild to moderate in severity and may lessen over time as your body adjusts to the medication. However, if any of these side effects persist or worsen, it’s important to inform your healthcare provider.

In addition to the common side effects mentioned above, Treprostinil Oral Inhalation may also cause more serious side effects in some individuals. These can include:

  • Severe allergic reactions (such as rash, itching, swelling of the face, lips, or tongue, severe dizziness, or trouble breathing)
  • Fainting or near-fainting episodes (syncope)
  • Worsening of pulmonary hypertension symptoms
  • Low blood pressure (hypotension)
  • Serious lung problems (such as pneumonia or bronchitis)

If you experience any severe or persistent side effects while using Treprostinil Oral Inhalation, it’s crucial to seek medical attention promptly. Your healthcare provider can assess your symptoms and determine the appropriate course of action.

It’s important to note that this list of side effects is not exhaustive, and other side effects may occur. Always discuss any concerns or questions about side effects with your healthcare provider. They can provide personalized advice and guidance based on your individual medical history and current health status.

What should I know about storage and disposal of this medication?

Storage and disposal of Treprostinil Oral Inhalation:


  • Store Treprostinil Oral Inhalation at room temperature, away from light and moisture.
  • Do not store it in the bathroom.
  • Keep Treprostinil Oral Inhalation out of reach of children.
  • Keep the inhaler device in its protective case when not in use.
  • Do not puncture or incinerate the inhaler canister, even if it is empty.


  • Dispose of expired or unused Treprostinil Oral Inhalation according to local regulations or guidelines.
  • Do not flush Treprostinil Oral Inhalation down the toilet or pour it into a drain unless instructed to do so by your healthcare provider or pharmacist.
  • Consult your pharmacist or local waste disposal company for proper disposal instructions.

In case of emergency/overdose

In case of emergency or overdose of Treprostinil Oral Inhalation, it’s essential to seek immediate medical attention or contact a poison control center. Symptoms of overdose may include severe headache, flushing, low blood pressure, dizziness, nausea, vomiting, and fainting. Be prepared to provide information about the amount of medication ingested and any symptoms experienced.

What other information should I know?

  • Follow your healthcare provider’s instructions carefully when using Treprostinil Oral Inhalation.
  • Do not change the dosage or frequency of use without consulting your healthcare provider.
  • Attend all follow-up appointments with your healthcare provider for monitoring and adjustments to your treatment plan.
  • Inform all healthcare providers involved in your care that you are using Treprostinil Oral Inhalation, including dentists and emergency medical personnel.
  • Carry identification or wear a medical alert bracelet indicating that you are taking Treprostinil Oral Inhalation, especially when traveling or in case of emergencies.
  • Keep a supply of Treprostinil Oral Inhalation on hand, and refill your prescription before you run out to avoid interruptions in treatment.
  • If you have any questions or concerns about Treprostinil Oral Inhalation or its use, consult your healthcare provider or pharmacist for guidance.

By following these guidelines and staying informed about Treprostinil Oral Inhalation, you can use the medication safely and effectively as part of your treatment for pulmonary arterial hypertension.

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