Why is this medication prescribed?

Treanda (bendamustine) is a medication primarily prescribed for the treatment of certain types of cancer, including chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), and multiple myeloma. It belongs to a class of drugs known as alkylating agents, which work by interfering with the growth and spread of cancer cells in the body.

How should this medicine be used?

Treanda (bendamustine) is typically administered intravenously (IV) by a healthcare professional in a clinical setting, such as a hospital or infusion center. The dosage and frequency of administration depend on various factors, including the type of cancer being treated, the patient’s overall health, and their individual response to the medication. Here are some general guidelines for using Treanda:

• Administration: Treanda is administered intravenously, usually over a period of 30 to 60 minutes. Your healthcare provider will dilute the medication in a solution and deliver it through a vein.
• Dosage: The dosage of Treanda varies depending on the specific type of cancer being treated and other individual factors. Your healthcare provider will determine the appropriate dose for you based on your medical history and response to treatment.
• Treatment Schedule: The frequency of Treanda administration also varies depending on the type of cancer and treatment plan. Typically, Treanda is given on a specific schedule, such as every 21 or 28 days. Your healthcare provider will advise you on the recommended treatment schedule.
• Monitoring: During treatment with Treanda, your healthcare provider will monitor you closely for any side effects and assess the medication’s effectiveness. They may perform blood tests and other evaluations to monitor your response to treatment.
• Side Effects Management: Treanda can cause side effects, including nausea, vomiting, fatigue, low blood cell counts, and increased risk of infection. Your healthcare provider will provide guidance on managing these side effects and may prescribe medications to alleviate symptoms or prevent complications.
• Follow-Up Care: It’s essential to attend all scheduled appointments with your healthcare provider during and after treatment with Treanda. They will monitor your progress, adjust your treatment plan as needed, and provide ongoing support and care.

It’s crucial to follow your healthcare provider’s instructions carefully when using Treanda and to communicate any concerns or questions you may have. They can provide personalized guidance based on your individual situation and medical needs.

Other uses for this medicine

Treanda (bendamustine) is primarily used in the treatment of certain types of cancer, including chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL), and multiple myeloma. However, there may be off-label or investigational uses for Treanda in other types of cancer or conditions. It’s essential to discuss any potential alternative uses of Treanda with your healthcare provider, as they can provide personalized guidance based on your individual medical history and needs.

What special precautions should I follow?

Regarding special precautions for using Treanda, here are some important points to consider:

• Allergies: Before receiving Treanda, inform your healthcare provider if you are allergic to bendamustine or any other medications. This medication may contain inactive ingredients that can cause allergic reactions or other problems.
• Pregnancy and breastfeeding: Treanda may harm an unborn baby if used during pregnancy. Therefore, it’s crucial to discuss the risks and benefits of Treanda with your healthcare provider if you are pregnant or planning to become pregnant. It’s also not recommended to breastfeed while receiving Treanda treatment, as it may harm the nursing infant.
• Blood cell counts: Treanda can cause a decrease in blood cell counts, including white blood cells, red blood cells, and platelets. Your healthcare provider will monitor your blood cell counts regularly during treatment to detect any abnormalities and adjust your treatment plan accordingly.
• Infections: Because Treanda can lower your body’s ability to fight infections, it’s essential to avoid contact with people who have infections, and to practice good hygiene to reduce the risk of infection. Notify your healthcare provider if you develop signs of infection, such as fever, chills, or sore throat.
• Liver and kidney function: Treanda is metabolized by the liver and excreted by the kidneys. If you have liver or kidney problems, your healthcare provider may need to adjust your Treanda dosage or monitor you more closely during treatment.
• Other medications: Inform your healthcare provider about all the medications, vitamins, and supplements you are currently taking, as they may interact with Treanda and affect its effectiveness or increase the risk of side effects.
• Fertility: Treanda may cause infertility or temporary loss of fertility in both men and women. Discuss fertility preservation options with your healthcare provider before starting treatment if preserving fertility is a concern.

It’s crucial to follow your healthcare provider’s instructions carefully and to communicate any concerns or questions you may have about Treanda. They can provide personalized guidance and support throughout your treatment journey.

What special dietary instructions should I follow?

Regarding special dietary instructions for Treanda, there are no specific dietary restrictions associated with this medication. However, maintaining a balanced and nutritious diet can support overall health and well-being during cancer treatment. Stay hydrated and follow any dietary recommendations provided by your healthcare provider or dietitian.

What should I do if I forget a dose?

If you forget a dose of Treanda, contact your healthcare provider or treatment team for guidance. Depending on the treatment schedule and how long it has been since the missed dose, they may recommend rescheduling the dose or adjusting your treatment plan. It’s essential not to double the dose to make up for a missed one without consulting your healthcare provider first. Consistency in treatment is crucial for the effectiveness of cancer therapy, so try to adhere to the prescribed schedule as closely as possible.

What side effects can this medication cause?

Treanda (bendamustine) can cause various side effects, ranging from mild to severe. Not everyone will experience all of these side effects, and their severity can vary from person to person. Common side effects of Treanda include:

• Nausea and vomiting
• Fatigue
• Diarrhea or constipation
• Loss of appetite
• Headache
• Fever or chills
• Weakness
• Injection site reactions (if administered intravenously)
• Low blood cell counts, including:
  • Anemia (low red blood cell count), leading to fatigue and weakness
  • Neutropenia (low white blood cell count), increasing the risk of infections
  • Thrombocytopenia (low platelet count), leading to an increased risk of bleeding or bruising
• Increased susceptibility to infections due to decreased immune function
• Allergic reactions, including rash, itching, swelling, and difficulty breathing (rare but serious)
• Liver toxicity, characterized by yellowing of the skin or eyes (jaundice), dark urine, and abdominal pain (rare)
• Kidney problems, including changes in urine output or color (rare)
• Tumor lysis syndrome, a rare but potentially life-threatening complication characterized by the rapid breakdown of cancer cells, leading to metabolic imbalances and kidney damage

It’s essential to report any side effects experienced during Treanda treatment to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, some side effects may require immediate medical attention, so it’s crucial to seek medical help if you experience severe or concerning symptoms.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store Treanda vials or infusion bags at room temperature away from light and moisture. Do not freeze. Follow any specific storage instructions provided by your healthcare provider or pharmacist.
• Disposal: Dispose of any unused or expired Treanda medication properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Consult with your pharmacist or healthcare provider for guidance on proper disposal methods.

In case of emergency/overdose

In case of an emergency or overdose with Treanda, seek immediate medical attention or contact a poison control center (such as the Poison Help hotline in the United States at 1-800-222-1222). Overdose symptoms may include severe nausea, vomiting, diarrhea, fever, chills, unusual bleeding or bruising, or signs of infection. Be prepared to provide information about the amount of medication ingested and any other relevant details.

What other information should I know?

• Treanda may increase your risk of infections, so avoid close contact with people who have infections. Practice good hygiene and notify your healthcare provider promptly if you develop signs of infection.
• Treanda can cause bone marrow suppression, leading to low blood cell counts. Your healthcare provider will monitor your blood cell counts regularly during treatment.
• Inform all healthcare providers involved in your care (including dentists and specialists) that you are receiving Treanda treatment, as it may interact with other medications or treatments.
• Attend all scheduled appointments for follow-up visits and monitoring during and after Treanda treatment.
• Inform your healthcare provider if you experience any new or worsening symptoms or side effects during treatment with Treanda.

It’s essential to follow all instructions provided by your healthcare provider and pharmacist when using Treanda, and to communicate any questions or concerns you may have. They can provide personalized guidance and support throughout your treatment journey.