WARNING

Trazimera (trastuzumab-qyyp) is a medication used to treat certain types of cancer, particularly HER2-positive breast cancer and gastric cancer. Like any medication, it comes with potential risks and side effects. Some of the risks associated with Trazimera include:

• Heart problems: Trazimera can cause heart-related side effects, including heart failure. Patients may experience symptoms such as shortness of breath, swelling of the ankles or feet, and sudden weight gain. It’s important for patients to undergo regular cardiac monitoring while receiving treatment with Trazimera.
• Infusion reactions: Some patients may experience infusion-related reactions during or shortly after receiving Trazimera. These reactions can range from mild to severe and may include symptoms such as fever, chills, nausea, vomiting, and difficulty breathing. Patients are typically monitored closely during infusion to manage any potential reactions.
• Harm to developing fetus: Trazimera may cause harm to a developing fetus if used during pregnancy. It’s important for women of childbearing age to use effective contraception while receiving treatment with Trazimera and to discuss the risks and benefits with their healthcare provider.
• Infections: Trazimera can suppress the immune system, increasing the risk of infections. Patients should be vigilant for signs of infection, such as fever, and seek medical attention if they occur.
• Other side effects: Other potential side effects of Trazimera may include diarrhea, headaches, fatigue, and muscle pain.

It’s essential for patients to discuss the potential risks and benefits of Trazimera with their healthcare provider before starting treatment. Additionally, patients should report any concerning symptoms or side effects to their healthcare team promptly.

Why is this medication prescribed?

Trazimera (trastuzumab-qyyp) is prescribed primarily for the treatment of certain types of cancer, particularly HER2-positive breast cancer and gastric (stomach) cancer. HER2-positive breast cancer is a type of breast cancer that overexpresses a protein called human epidermal growth factor receptor 2 (HER2), which promotes the growth of cancer cells. Trazimera works by targeting and blocking the HER2 protein, thereby slowing down or stopping the growth of cancer cells.

In breast cancer, Trazimera may be used in combination with chemotherapy or alone after chemotherapy, depending on the stage and characteristics of the cancer. In gastric cancer, it is typically used in combination with chemotherapy.

How should this medicine be used?

Trazimera (trastuzumab-qyyp) is typically used in the treatment of HER2-positive breast cancer and gastric cancer. It is administered through intravenous (IV) infusion, meaning it is delivered directly into a vein. Here’s how Trazimera is commonly used:

• Administration: Trazimera is administered by a healthcare professional in a clinic, hospital, or infusion center. It should not be self-administered.
• Dosage: The dosage of Trazimera varies depending on factors such as the type and stage of cancer being treated, as well as individual patient factors like weight and overall health. The healthcare provider will determine the appropriate dosage for each patient.
• Frequency: Trazimera treatment is typically given on a schedule determined by the healthcare provider. This schedule often involves receiving Trazimera once every one to three weeks, with breaks between cycles of treatment.
• Duration: The duration of Trazimera treatment can vary based on the specific cancer being treated, the response to treatment, and other factors. Some patients may receive Trazimera for a relatively short period, while others may require longer-term treatment.
• Monitoring: Throughout the course of Trazimera treatment, patients are closely monitored by their healthcare team for any signs of side effects or complications. This monitoring may include regular physical exams, blood tests, and imaging studies.
• Combination therapy: Trazimera is often used in combination with other cancer treatments, such as chemotherapy or hormone therapy, depending on the specific circumstances of each patient’s cancer.

It’s crucial for patients to follow their healthcare provider’s instructions precisely regarding the use of Trazimera and to attend all scheduled appointments for treatment and monitoring. Additionally, patients should report any concerning symptoms or side effects to their healthcare team promptly.

Other uses for this medicine

Trazimera (trastuzumab-qyyp) is primarily used for the treatment of HER2-positive breast cancer and gastric cancer. However, it may also be used in certain other cancers or conditions as determined by healthcare providers, although such uses are less common and may involve off-label prescribing.

What special precautions should I follow?

Special precautions should be observed when using Trazimera:

• Heart function monitoring: Trazimera can cause cardiac side effects, including heart failure. Patients should undergo baseline cardiac evaluation before starting treatment with Trazimera, and regular monitoring of cardiac function, such as echocardiograms or MUGA scans, should be conducted during treatment. Any signs or symptoms of heart problems, such as shortness of breath or swelling of the ankles, should be reported to the healthcare provider promptly.
• Infusion reactions: Infusion-related reactions, ranging from mild to severe, may occur during or after Trazimera administration. Patients are usually monitored closely during infusion and for a period afterward to manage any potential reactions. Pre-treatment with medications such as antihistamines or corticosteroids may be recommended to reduce the risk of infusion reactions.
• Infections: Trazimera can suppress the immune system, increasing the risk of infections. Patients should avoid close contact with individuals who have contagious illnesses, practice good hygiene, and promptly report any signs of infection to their healthcare provider.
• Pregnancy and breastfeeding: Trazimera may cause harm to a developing fetus if used during pregnancy. Women of childbearing age should use effective contraception during treatment and for a period afterward. Breastfeeding is not recommended during treatment with Trazimera.
• Interactions with other medications: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking, as Trazimera may interact with certain medications.
• Liver and kidney function: Trazimera may affect liver and kidney function. Patients with pre-existing liver or kidney conditions should be monitored closely during treatment.
• Hypersensitivity reactions: Patients with known hypersensitivity to trastuzumab or any of the ingredients in Trazimera should not receive the medication.

It’s essential for patients to discuss their medical history, including any pre-existing conditions or medications, with their healthcare provider before starting treatment with Trazimera. Following the healthcare provider’s recommendations and attending regular follow-up appointments can help ensure the safe and effective use of Trazimera.

What special dietary instructions should I follow?

Regarding special dietary instructions for Trazimera, there are no specific dietary restrictions associated with this medication. However, it’s essential for patients to maintain a balanced and nutritious diet to support their overall health and well-being during cancer treatment. Patients should consult with their healthcare provider or a registered dietitian for personalized dietary advice.

What should I do if I forget a dose?

If a dose of Trazimera is missed, patients should contact their healthcare provider for guidance. In some cases, the missed dose may be rescheduled or adjusted based on the treatment plan. It’s essential not to double the dose to make up for a missed one without consulting a healthcare provider, as this can increase the risk of side effects or complications.

What side effects can this medication cause?

Trazimera (trastuzumab-qyyp) can cause various side effects, ranging from mild to severe. It’s important for patients to be aware of these potential side effects and to promptly report any concerning symptoms to their healthcare provider. Some common side effects of Trazimera include:

• Infusion reactions: These can occur during or shortly after Trazimera infusion and may include symptoms such as fever, chills, nausea, vomiting, itching, rash, or difficulty breathing.
• Heart problems: Trazimera can cause heart-related side effects, including decreased heart function, heart failure, and irregular heartbeats (arrhythmias). Symptoms may include shortness of breath, swelling of the ankles or feet, rapid weight gain, or chest pain.
• Infections: Trazimera may weaken the immune system, increasing the risk of infections such as respiratory infections, urinary tract infections, or skin infections.
• Diarrhea: Some patients may experience diarrhea as a side effect of Trazimera treatment.
• Headaches: Headaches are a relatively common side effect of Trazimera.
• Fatigue: Trazimera treatment may cause fatigue or weakness in some patients.
• Muscle pain: Some patients may experience muscle pain or weakness while receiving Trazimera.
• Nausea and vomiting: These gastrointestinal symptoms may occur as side effects of Trazimera treatment.
• Hypersensitivity reactions: Rarely, Trazimera can cause severe allergic reactions (anaphylaxis) or other hypersensitivity reactions.
• Decreased white blood cell count: Trazimera may cause a decrease in white blood cell count (neutropenia), increasing the risk of infections.

It’s important for patients to discuss potential side effects with their healthcare provider before starting treatment with Trazimera. Additionally, patients should report any new or worsening symptoms to their healthcare team promptly, as timely intervention can help manage side effects effectively.

What should I know about storage and disposal of this medication?

Regarding storage and disposal of Trazimera:

Storage:

• Trazimera should be stored in its original packaging at room temperature, away from excessive heat, moisture, and light.
• Do not freeze Trazimera.
• Keep Trazimera out of reach of children and pets.
• Follow any specific storage instructions provided by your healthcare provider or pharmacist.

Disposal:

• Unused or expired Trazimera should be disposed of properly according to local regulations or guidelines.
• Do not dispose of Trazimera in household trash or flush it down the toilet unless instructed to do so by your healthcare provider or pharmacist.
• Consult your healthcare provider or pharmacist for guidance on proper disposal methods for Trazimera.

In case of emergency/overdose

In case of emergency or overdose of Trazimera, you should:

• Contact emergency medical services (e.g., call 911) or go to the nearest emergency room immediately.
• If possible, bring the Trazimera packaging or any remaining medication with you to the emergency room to assist healthcare providers in providing appropriate treatment.
• Do not attempt to treat an overdose of Trazimera on your own without medical supervision.

What other information should I know?

• Trazimera is a prescription medication that should only be used under the supervision of a qualified healthcare provider.
• Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting treatment with Trazimera, as interactions may occur.
• Attend all scheduled appointments for Trazimera treatment and follow-up visits with your healthcare provider.
• Report any new or worsening symptoms to your healthcare provider promptly, as timely intervention can help manage side effects effectively.
• Follow your healthcare provider’s instructions regarding Trazimera dosage, administration, and monitoring closely to ensure safe and effective treatment.