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Tezepelumab Injection

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Why is this medication prescribed?

Tezepelumab injection is prescribed for the treatment of severe asthma in adults and adolescents aged 12 years and older. It is specifically indicated for patients who have an eosinophilic phenotype or have oral corticosteroid-dependent asthma.

Tezepelumab is a monoclonal antibody that works by blocking the action of a protein called thymic stromal lymphopoietin (TSLP), which plays a key role in the inflammatory process involved in asthma. By inhibiting TSLP, tezepelumab helps reduce airway inflammation and asthma symptoms.

How should this medicine be used?

Tezepelumab injection is typically administered as a subcutaneous injection, which means it is injected under the skin. Here are the general guidelines for using tezepelumab injection:

  • Preparation:
    • Wash your hands thoroughly with soap and water.
    • Ensure that the medication has been stored properly according to the manufacturer’s instructions.
    • Inspect the medication to ensure it is not expired and that the solution is clear and free of particles or discoloration.
    • If the medication needs to be refrigerated, allow it to come to room temperature before administration. Do not shake the vial.
  • Administration:
    • Choose a clean, dry injection site on the abdomen, thigh, or upper arm.
    • Clean the injection site with an alcohol swab and allow it to air dry.
    • Use a new, sterile needle and syringe provided by the manufacturer for each injection.
    • Remove the cap from the needle and syringe.
    • Hold the syringe like a pencil and insert the needle into the skin at a 45 to 90-degree angle.
    • Inject the medication slowly and steadily.
    • Once the injection is complete, remove the needle and apply gentle pressure to the injection site with a sterile gauze pad.
    • Dispose of the needle and syringe properly according to local regulations.
  • Aftercare:
    • Dispose of all used materials in a sharps container.
    • Monitor the injection site for any signs of redness, swelling, or irritation.
    • Keep track of your injection schedule and ensure you receive your injections at the prescribed intervals.

It’s essential to follow the specific instructions provided by your healthcare provider for the administration of tezepelumab injection. They may provide additional guidance or recommendations based on your individual circumstances. If you have any questions or concerns about administering the medication, be sure to consult your healthcare provider or pharmacist for assistance.

Other uses for this medicine

Tezepelumab injection is primarily indicated for the treatment of severe asthma in adults and adolescents aged 12 years and older who have an eosinophilic phenotype or are oral corticosteroid-dependent. However, it’s important to note that medications may sometimes be prescribed off-label for conditions not specifically approved by regulatory agencies. Off-label use of tezepelumab injection would be at the discretion of the prescribing healthcare provider based on their clinical judgment and the individual patient’s needs.

What special precautions should I follow?

Regarding special precautions for tezepelumab injection, it’s essential to follow your healthcare provider’s instructions carefully. Here are some general precautions to consider:

  • Allergies: Inform your healthcare provider about any known allergies, especially to medications or ingredients in tezepelumab injection.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of tezepelumab with your doctor.
  • Immunizations: Avoid live vaccines while on tezepelumab treatment, as it may interfere with the efficacy of vaccines.
  • Infections: Tezepelumab can increase the risk of infections. Inform your healthcare provider if you develop signs or symptoms of infection, such as fever, chills, cough, or unusual fatigue.
  • Monitoring: Regular monitoring may be necessary while on tezepelumab therapy to assess its effectiveness and monitor for any adverse effects.

Always consult your healthcare provider for personalized advice regarding the use of tezepelumab injection and any special precautions specific to your medical history and condition.

What special dietary instructions should I follow?

As for special dietary instructions, there are typically no specific dietary restrictions associated with Tezepelumab Injection. However, it’s always a good idea to follow a balanced and healthy diet as recommended by your healthcare provider, especially if you have any underlying medical conditions.

What should I do if I forget a dose?

If you forget a dose of Tezepelumab, contact your healthcare provider or seek guidance from a medical professional. They will advise you on the best course of action, which may include rescheduling the missed dose or adjusting your treatment plan accordingly. It’s crucial not to double up on doses unless specifically instructed to do so by your healthcare provider.

What side effects can this medication cause?

Tezepelumab Injection, like any medication, can potentially cause side effects. Common side effects reported in clinical trials and post-marketing surveillance may include:

  • Upper Respiratory Tract Infections: These are the most commonly reported side effects, including nasopharyngitis (common cold), sinusitis, and upper respiratory tract infection.
  • Injection Site Reactions: Pain, redness, or swelling at the injection site may occur.
  • Headache: Some individuals may experience headaches while on Tezepelumab therapy.
  • Musculoskeletal Pain: This can include pain in the muscles or joints.
  • Fatigue: Feeling tired or fatigued is another reported side effect.
  • Gastrointestinal Symptoms: These may include diarrhea or abdominal pain.
  • Allergic Reactions: While rare, allergic reactions to Tezepelumab can occur. Seek immediate medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s essential to discuss any concerns or potential side effects with your healthcare provider before starting Tezepelumab treatment. They can provide personalized guidance and monitor your response to the medication. Additionally, always report any unexpected or severe side effects to your healthcare provider promptly.

What should I know about storage and disposal of this medication?

Storage and Disposal:


  • Tezepelumab Injection should be stored in the refrigerator at a temperature between 2°C to 8°C (36°F to 46°F).
  • Do not freeze Tezepelumab or expose it to temperatures above 25°C (77°F).
  • Keep the medication in its original carton to protect it from light.
  • Do not shake the vial; gently swirl it to dissolve any residue.


  • Dispose of Tezepelumab Injection vials and materials used for injection according to local regulations.
  • Do not dispose of medication in household trash or flush it down the toilet unless instructed to do so by your healthcare provider or local waste disposal authority.

In case of emergency/overdose

  • In case of emergency or overdose, seek immediate medical attention or contact your regional poison control center.
  • Symptoms of overdose may include an increased risk of infection or exacerbation of known side effects.

What other information should I know?

  • Tezepelumab Injection is intended for use under the guidance and supervision of a healthcare professional.
  • Do not share Tezepelumab with others, even if they have similar symptoms or conditions.
  • Inform all healthcare providers involved in your care that you are receiving Tezepelumab Injection.
  • Attend all scheduled appointments for monitoring and follow-up with your healthcare provider.
  • Report any new or worsening symptoms, side effects, or concerns to your healthcare provider promptly.
  • Keep Tezepelumab out of the reach of children and pets.

It’s important to follow these instructions carefully to ensure the safe and effective use of Tezepelumab Injection. If you have any questions or concerns about storage, disposal, emergency procedures, or any other aspect of your treatment, consult your healthcare provider for guidance.

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