Why is this medication prescribed?
Tepotinib is a tyrosine kinase inhibitor that targets the MET receptor, which is involved in the growth and spread of certain cancer cells. Tepotinib is primarily prescribed for the treatment of metastatic non-small cell lung cancer (NSCLC) with specific genetic alterations, such as MET exon 14 skipping mutations.
How should this medicine be used?
Here are some general guidelines that may be associated with tepotinib use:
- Dosage: The prescribed dosage can vary, and it is important to take the medication as directed by your healthcare provider. Do not alter the dosage without consulting your healthcare team.
- Administration: Tepotinib is usually taken orally, with or without food. Follow the specific instructions provided by your healthcare provider or the medication’s prescribing information.
- Adherence: Take tepotinib regularly and at the same time each day unless directed otherwise by your healthcare provider. If you miss a dose, follow the guidance provided by your healthcare team.
- Side Effects: Be aware of potential side effects associated with tepotinib. Report any unusual or severe side effects to your healthcare provider promptly.
- Interactions: Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they may interact with tepotinib.
- Regular Monitoring: Your healthcare provider may schedule regular check-ups and laboratory tests to monitor your response to the treatment and assess for any potential side effects.
It’s important to note that the information provided here is general, and individual circumstances may require specific adjustments to the treatment plan. Always consult with your healthcare provider for personalized advice and guidance on the use of tepotinib. If there have been any updates or changes to the guidelines since last update, your healthcare provider will have the most current information.
Other uses for this medicine
Tepotinib is primarily used for the treatment of metastatic non-small cell lung cancer (NSCLC) with specific genetic alterations, such as MET exon 14 skipping mutations. There may be ongoing clinical trials and research investigating the potential use of tepotinib in other types of cancer or conditions, but the approved indications can vary by region and may change over time.
What special precautions should I follow?
Regarding special precautions for tepotinib use, it’s crucial to follow your healthcare provider’s guidance and adhere to the prescribed treatment plan. Here are some general precautions associated with the use of targeted therapies like tepotinib:
- Medical History: Inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or other medications you are taking. This information can help in determining the suitability of tepotinib for your specific situation.
- Pregnancy and Breastfeeding: Tepotinib may pose risks during pregnancy, and it is essential to discuss family planning and contraception methods with your healthcare provider. If you are pregnant or breastfeeding, inform your healthcare team, as the potential risks and benefits need to be carefully considered.
- Liver Function: Tepotinib is metabolized in the liver, so it is important to monitor liver function regularly during treatment. Your healthcare provider may perform blood tests to assess liver enzymes.
- Cardiovascular Effects: Some targeted therapies, including tepotinib, may have cardiovascular effects. Inform your healthcare provider if you have a history of heart disease or if you experience symptoms such as chest pain or shortness of breath.
- Interactions with Other Medications: Tepotinib may interact with other medications, including over-the-counter drugs, vitamins, and herbal supplements. Provide a comprehensive list of all medications and supplements to your healthcare provider.
- Adverse Reactions: Be vigilant for any signs of adverse reactions or side effects. Report any unusual symptoms, such as severe fatigue, bleeding, or persistent gastrointestinal issues, to your healthcare provider promptly.
It’s important to note that these precautions are general in nature, and the specific recommendations may vary based on individual patient characteristics and the latest medical guidelines. Always consult with your healthcare provider for personalized advice and information tailored to your specific health condition and treatment plan. If there have been any updates or changes since last update, your healthcare provider will have the most current information.
What special dietary instructions should I follow?
Special Dietary Instructions:
- Administration with or without Food: Tepotinib is usually taken orally, and it may be prescribed to be taken with or without food. Follow the specific instructions provided by your healthcare provider or the prescribing information.
- Potential Interactions with Grapefruit: Grapefruit and grapefruit juice can interact with some medications, affecting their absorption. Consult with your healthcare provider regarding the consumption of grapefruit or grapefruit products while taking tepotinib.
What should I do if I forget a dose?
- Prompt Consultation: If you forget to take a dose of tepotinib, it’s important to consult with your healthcare provider promptly for guidance on what to do next.
- Avoid Double Dosing: Do not take a double dose to make up for a missed one unless explicitly instructed to do so by your healthcare provider.
- Follow Instructions: Follow the specific guidance provided by your healthcare provider for managing missed doses. They may provide specific instructions based on your treatment plan and medical condition.
What side effects can this medication cause?
As with any medication, tepotinib may cause side effects. It’s important to note that individual responses to medications can vary, and not everyone will experience the same side effects. The information provided here is based on last update, and there may have been developments or additional information since then.
Common side effects associated with tepotinib, as reported in clinical trials, may include:
- Peripheral Edema: Swelling in the hands, ankles, or feet.
- Nausea: A feeling of discomfort or queasiness in the stomach.
- Fatigue: Unusual tiredness or weakness.
- Decreased Appetite: A reduced desire to eat.
- Vomiting: The act of expelling stomach contents through the mouth.
- Dysgeusia: Changes in taste perception.
- Increased Blood Creatinine: Elevated levels of creatinine in the blood, indicating kidney function.
- Diarrhea: Frequent, loose, or watery stools.
- Musculoskeletal Pain: Pain or discomfort in the muscles or bones.
- Elevated Liver Enzymes: Changes in liver function tests.
- Rash: Skin reactions or changes.
It’s important to report any side effects or symptoms to your healthcare provider promptly. In some cases, side effects may be manageable with supportive care or dose adjustments. Serious side effects are less common but can occur, and your healthcare provider will monitor for them during your treatment.
Additionally, this list is not exhaustive, and there may be other side effects associated with tepotinib. Always refer to the prescribing information provided with the medication or consult your healthcare provider for the most up-to-date and comprehensive information.
If you experience severe or persistent side effects, seek medical attention immediately. Your healthcare team is the best resource for addressing concerns related to your specific health condition and medication use.
What should I know about storage and disposal of this medication?
Storage of Tepotinib:
- Temperature: Store tepotinib at room temperature, usually between 68°F to 77°F (20°C to 25°C). Avoid exposure to extreme temperatures, and keep the medication in its original packaging.
- Container: Keep tepotinib in its original container with the lid tightly closed to protect it from moisture.
- Keep Out of Reach of Children: Store medications in a location that is out of reach of children and pets.
Disposal of Tepotinib:
- Follow Local Regulations: Dispose of unused or expired medication in accordance with local regulations and guidelines.
- Do Not Flush: Do not flush medications down the toilet unless specifically instructed to do so. Check with your local pharmacy or healthcare provider for safe disposal options.
In case of emergency/overdose
- Seek Immediate Medical Attention: If you suspect an overdose or experience severe side effects, seek emergency medical attention or contact your local poison control center.
- Symptoms of Overdose: Symptoms of overdose may vary but could include increased severity of known side effects, such as nausea, vomiting, or diarrhea.
What other information should I know?
- Regular Follow-up: Attend regular follow-up appointments with your healthcare provider to monitor your response to tepotinib and address any concerns or side effects.
- Lab Tests: Your healthcare provider may conduct regular blood tests to monitor your liver function and other relevant parameters.
- Inform Healthcare Providers: Keep your healthcare providers informed about all medications, including over-the-counter drugs and supplements, that you are taking. This includes any changes in your medications during the course of treatment.
- Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as these factors may influence the treatment plan.
- Clinical Updates: Stay informed about updates or changes in the clinical guidelines for tepotinib. Your healthcare provider will have the most current information.
Always consult with your healthcare provider or pharmacist for the latest and most accurate information regarding the storage, disposal, and emergency procedures related to tepotinib. If there have been any updates or changes since last update, your healthcare provider will have the most current information.