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Tepmetko (Generic Tepotinib)

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Why is this medication prescribed?

Tepmetko (tepotinib) is a prescription medication used to treat certain types of non-small cell lung cancer (NSCLC). It is specifically indicated for the treatment of adult patients with metastatic NSCLC whose tumors have a mesenchymal-epithelial transition (MET) exon 14 skipping alteration. MET exon 14 skipping alterations are genetic mutations that can occur in cancer cells.

Tepmetko is a tyrosine kinase inhibitor that works by targeting the MET receptor and inhibiting its activity. This helps to block the signals that promote the growth and survival of cancer cells.

How should this medicine be used?

The information provided here is general, and specific instructions for Tepmetko (tepotinib) use should be obtained from a healthcare professional. The dosage and administration of Tepmetko can vary based on individual patient factors, and it’s crucial to follow the prescribing physician’s recommendations. As of last update, the general information about Tepmetko is as follows:

  • Dosage: The recommended dosage of Tepmetko may vary, and it is determined by the healthcare provider based on factors such as the patient’s overall health, specific medical conditions, and individual response to the medication.
  • Administration: Tepmetko is usually taken orally, with or without food. The tablets should be swallowed whole with a glass of water, and they should not be crushed, broken, or chewed.
  • Schedule: The medication is typically taken once daily. It’s important to follow the prescribed schedule consistently and not miss any doses.
  • Follow-up: Patients are advised to attend regular follow-up appointments with their healthcare provider to monitor their response to treatment and manage any potential side effects.
  • Special Instructions: Patients should inform their healthcare provider about any other medications, supplements, or herbal products they are taking, as they may interact with Tepmetko. It’s essential to report any side effects or concerns to the healthcare provider promptly.

Remember, this information is not a substitute for professional medical advice. If you or someone you know is prescribed Tepmetko, it is crucial to consult with a healthcare professional for specific and personalized instructions based on the individual’s medical condition and history. Additionally, medication guidelines may have been updated, so it’s important to refer to the latest medical resources or consult with a healthcare professional for the most current information.

Other uses for this medicine

Tepmetko (tepotinib) is primarily indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) with MET exon 14 skipping alterations. It is a targeted therapy specifically designed for this purpose. However, it’s important to note that medical information can change, and new uses may have been identified since then.

What special precautions should I follow?

As for special precautions, individuals taking Tepmetko should follow their healthcare provider’s guidance and be aware of the following considerations:

  • Pre-existing Conditions: Inform your healthcare provider about any pre-existing medical conditions, especially liver problems or other significant health issues.
  • Medication Interactions: Report all medications, including prescription and over-the-counter drugs, as well as supplements and herbal products, to your healthcare provider. Tepmetko may interact with other medications.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The potential risks and benefits of Tepmetko during pregnancy and breastfeeding should be discussed.
  • Liver Function: Tepmetko may affect liver function. Regular monitoring of liver function tests may be required during treatment.
  • Side Effects: Be aware of potential side effects of Tepmetko and promptly report any unusual symptoms or adverse reactions to your healthcare provider.
  • Dose Adjustments: Dose adjustments or interruptions may be necessary based on individual responses, tolerability, and potential side effects. It is essential to follow your healthcare provider’s recommendations regarding dose modifications.
  • Regular Follow-up: Attend scheduled follow-up appointments with your healthcare provider to monitor your response to treatment and address any concerns or questions.

It’s crucial to consult directly with your healthcare provider for personalized advice and to stay informed about the latest safety information and precautions associated with Tepmetko. The information provided here is based on knowledge, and developments in medical guidelines may have occurred.

What special dietary instructions should I follow?

As of last update, specific dietary instructions for Tepmetko may not be well-established. However, it’s advisable to follow a balanced and nutritious diet unless your healthcare provider provides specific guidance based on your individual health status.

What should I do if I forget a dose?

If you forget to take a dose of Tepmetko, follow these general guidelines:

  • Take the Missed Dose as Soon as Possible: If you remember shortly after the missed dose, take it as soon as you remember.
  • Skip the Missed Dose if It’s Almost Time for the Next Dose: If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
  • Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking extra medication may increase the risk of side effects.

What side effects can this medication cause?

Tepmetko (tepotinib) can cause various side effects, and it’s important for individuals taking the medication to be aware of potential adverse reactions. Keep in mind that the following list is not exhaustive, and the severity and occurrence of side effects can vary from person to person. Always consult with your healthcare provider for personalized information. As of last update, common side effects of Tepmetko may include:

  • Peripheral Edema: Swelling in the arms, hands, legs, or feet.
  • Nausea: Feeling of sickness or discomfort in the stomach with an inclination to vomit.
  • Diarrhea: Abnormal and frequent bowel movements that may be loose or watery.
  • Fatigue: Feeling tired or weak.
  • Decreased Appetite: Reduction in the desire to eat.
  • Vomiting: The act of expelling stomach contents through the mouth.
  • Dyspnea: Shortness of breath or difficulty breathing.
  • Musculoskeletal Pain: Pain or discomfort in muscles or bones.
  • Constipation: Difficulty in passing stools or infrequent bowel movements.
  • Cough: Persistent or recurrent coughing.
  • Rash: Skin eruption or discoloration.
  • Pyrexia: Fever.

It’s important to report any side effects to your healthcare provider, even if they seem mild, as they can provide guidance on managing symptoms or adjust the treatment plan if necessary. Additionally, there can be more serious side effects associated with Tepmetko, and individuals should seek medical attention if they experience any signs of severe reactions, such as:

  • Severe Allergic Reactions: Symptoms may include difficulty breathing, swelling of the face or throat, or severe skin rash.
  • Liver Problems: Signs may include yellowing of the skin or eyes (jaundice), dark urine, or persistent nausea.
  • Interstitial Lung Disease: Symptoms may include difficulty breathing, cough, or fever.

This list is not exhaustive, and individuals should refer to the medication’s prescribing information or consult with their healthcare provider for comprehensive details on potential side effects and what to watch for during treatment. Keep in mind that medical information is subject to change, and there may have been updates.

What should I know about storage and disposal of this medication?

Storage and Disposal of Tepmetko:


  • Store Tepmetko at room temperature, away from excessive heat or moisture.
  • Keep the medication in its original packaging and container to protect it from light.
  • Do not store Tepmetko in the bathroom, as moisture and humidity can affect its stability.


  • Dispose of Tepmetko according to local regulations or guidelines for medication disposal.
  • Do not flush medications down the toilet unless instructed to do so. Check with your local pharmacy or healthcare provider for safe disposal options.

In case of emergency/overdose

  • In case of an overdose or emergency, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention immediately.
  • Provide healthcare professionals with information about the medication and the amount taken.

What other information should I know?

  • Keep a list of all medications you are currently taking, including Tepmetko, and share it with your healthcare provider.
  • Inform healthcare providers, including dentists and emergency room personnel, that you are taking Tepmetko.
  • Attend all scheduled follow-up appointments with your healthcare provider to monitor your response to the medication and address any concerns.

It’s important to follow your healthcare provider’s instructions and consult with them or a pharmacist for any specific details regarding storage, disposal, or emergency situations related to Tepmetko. Medication information may have changed since last update, so it’s crucial to refer to the latest medical resources and guidelines for the most accurate and current information.

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