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Tazverik (Generic Tazemetostat)

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Why is this medication prescribed?

Tazverik (tazemetostat) is prescribed for the treatment of specific types of cancer, primarily epithelioid sarcoma. It is indicated for the following:

  • Epithelioid Sarcoma (ES): Tazverik is prescribed for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection (surgery to remove the tumor).

Epithelioid sarcoma is a rare and aggressive type of soft tissue sarcoma that tends to occur in young adults. Tazverik works by inhibiting the activity of the EZH2 protein, which plays a role in the growth of cancer cells.

How should this medicine be used?

Tazverik (tazemetostat) is typically an oral medication, meaning it is taken by mouth. Here are some general guidelines for the use of Tazverik:

  • Dosage: The healthcare provider will determine the appropriate dosage based on the patient’s individual factors, such as the type and stage of cancer, overall health, and other medications the patient may be taking.
  • Administration: Tazverik is usually taken with or without food, as directed by the healthcare provider. It’s essential to follow the specific instructions provided by the healthcare professional.
  • Timing: Take Tazverik exactly as prescribed. This may involve taking the medication at specific times of the day or following a particular schedule. Do not skip doses or alter the dosage without consulting the healthcare provider.
  • Swallowing: Swallow the Tazverik tablets whole with a glass of water. Do not crush, chew, or break the tablets.
  • Missed Dose: If a dose is missed, patients are generally advised to take it as soon as they remember. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed. It’s important not to take a double dose to make up for a missed one.
  • Follow-Up: Regular follow-up appointments with the healthcare provider are crucial. During these visits, the healthcare team will monitor the patient’s response to the medication, assess for any side effects, and make any necessary adjustments to the treatment plan.

It’s important to note that this information is based on last update, and prescribing guidelines may have changed since then. Always follow the guidance provided by the healthcare professional and refer to the medication’s official prescribing information for the most accurate and current details.

Other uses for this medicine

As of last update, Tazverik is primarily indicated for the treatment of epithelioid sarcoma. However, ongoing research and clinical trials may explore its potential use in other cancer types or conditions. Always consult with healthcare professionals for the most current information on drug indications.

What special precautions should I follow?

Special precautions and considerations for Tazverik use are typically outlined by healthcare professionals based on individual patient characteristics. Here are some general precautions that may be relevant:

  • Pregnancy and Breastfeeding: Tazverik may have the potential to cause harm to a developing fetus. Therefore, it is important to inform the healthcare provider if you are pregnant or planning to become pregnant. Breastfeeding individuals should also discuss the potential risks and benefits with their healthcare provider.
  • Liver Function: Tazverik can affect liver function, so patients may undergo regular liver function tests during treatment. Any signs of liver problems, such as jaundice (yellowing of the skin or eyes), abdominal pain, or dark urine, should be reported to the healthcare provider.
  • Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking. Tazverik may interact with other drugs, potentially affecting their effectiveness or causing adverse effects.
  • Allergies: Individuals with known allergies or hypersensitivity to tazemetostat or any of its components should not take Tazverik.
  • Side Effects: Be aware of potential side effects associated with Tazverik. Common side effects may include fatigue, nausea, vomiting, decreased appetite, and constipation. It’s important to promptly report any unusual or severe side effects to the healthcare provider.
  • Regular Monitoring: Patients taking Tazverik are often monitored regularly by healthcare professionals to assess treatment response, manage side effects, and adjust the treatment plan as needed.

It’s crucial to follow the specific guidance provided by the prescribing healthcare professional and to read the medication’s official prescribing information for the most up-to-date and detailed information on precautions, contraindications, and potential interactions.

As medical information evolves, new uses or precautions for Tazverik may emerge, so consulting with a healthcare provider or referring to updated sources is recommended. Always seek the advice of a qualified healthcare professional for personalized medical advice and guidance.

What special dietary instructions should I follow?

There were no specific dietary restrictions associated with Tazverik mentioned in the prescribing information. However, dietary instructions may vary depending on individual patient factors and any concurrent medical conditions. Always follow the dietary guidance provided by your healthcare provider.

What should I do if I forget a dose?

If you miss a dose of Tazverik, here are some general recommendations:

  • Take it as Soon as Possible: If you remember the missed dose within a relatively short time, take it as soon as possible.
  • Skip if Close to Next Dose: If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
  • Do Not Double Dose: Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Tazverik (tazemetostat) may cause various side effects, and it’s important for patients to be aware of potential reactions and promptly report any unusual or severe symptoms to their healthcare provider. The side effects can vary in severity and may not occur in every individual. Here are some common side effects associated with Tazverik:

  • Fatigue: Feeling tired or lacking energy is a common side effect.
  • Nausea: Some individuals may experience nausea or an upset stomach.
  • Vomiting: Vomiting may occur in some cases.
  • Decreased Appetite: A reduction in appetite or changes in eating habits.
  • Constipation: Some individuals may experience difficulty with bowel movements.
  • Muscle or Joint Pain: Pain or discomfort in the muscles or joints.
  • Dizziness: Feeling lightheaded or dizzy.
  • Increased Blood Creatinine: Tazverik may lead to an increase in blood creatinine levels, which is a marker of kidney function.
  • Changes in Electrocardiogram (ECG) Results: Tazverik may cause changes in ECG results.
  • Edema (Swelling): Swelling of the ankles, feet, or other parts of the body may occur.
  • Cough: Some individuals may experience coughing.
  • Shortness of Breath: Difficulty breathing or shortness of breath.

It’s important to note that the list above is not exhaustive, and other side effects may occur. Additionally, individual responses to medications can vary, so not everyone will experience the same side effects.

Patients should report any new or worsening symptoms to their healthcare provider, as some side effects may require medical attention. It’s crucial for individuals prescribed Tazverik to maintain regular communication with their healthcare team and attend scheduled follow-up appointments for monitoring.

What should I know about storage and disposal of this medication?

Storage and Disposal of Tazverik:


  • Temperature: Store Tazverik at the recommended temperature as specified in the prescribing information. Typically, it is stored at room temperature, away from excessive heat or moisture.
  • Container: Keep Tazverik in its original container, and ensure the container is tightly closed.
  • Keep Out of Reach of Children: Store the medication in a location that is out of reach of children and pets.


  • Follow Local Regulations: Dispose of Tazverik according to local regulations for the disposal of medications. Do not dispose of it in household trash unless specifically instructed to do so.
  • Take-Back Programs: Check if there are any local take-back programs or collection sites for the safe disposal of medications.

In case of emergency/overdose

In case of a suspected overdose or emergency, it is important to:

  • Seek Medical Attention: Contact emergency medical services or go to the nearest emergency room immediately.
  • Inform Healthcare Provider: If possible, inform your healthcare provider about the overdose incident.

What other information should I know?

  • Regular Monitoring: Patients prescribed Tazverik may undergo regular monitoring, including blood tests and imaging studies, to assess treatment response and manage potential side effects.
  • Follow-Up Appointments: Attend all scheduled follow-up appointments with your healthcare provider to discuss your progress, any side effects, and potential adjustments to the treatment plan.
  • Inform Healthcare Providers: Make sure all healthcare providers involved in your care are aware that you are taking Tazverik. This includes dentists, surgeons, and other specialists.
  • Avoid Grapefruit: Some medications can interact with grapefruit or its juice. Check with your healthcare provider about any dietary restrictions or considerations while taking Tazverik.
  • Patient Assistance Programs: If needed, inquire about patient assistance programs or support services that may be available to help with the cost or access to Tazverik.

Always follow the guidance provided by your healthcare provider and refer to the most recent prescribing information for Tazverik for any updates or changes in recommendations. If you have specific questions or concerns, consult with your healthcare team.

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