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Why is this medication prescribed?

Tazemetostat is prescribed for the treatment of specific cancers, particularly metastatic or locally advanced epithelioid sarcoma. Epithelioid sarcoma is a rare and aggressive form of soft tissue cancer. Tazemetostat is an epigenetic therapy that works as an EZH2 inhibitor, targeting a protein involved in the regulation of gene expression.

The goal of prescribing Tazemetostat is to inhibit the activity of EZH2, which plays a role in the development and progression of certain cancers. By inhibiting this protein, Tazemetostat aims to control the growth of cancer cells and potentially slow down the progression of the disease.

How should this medicine be used?

The information provided here is a general overview, and it’s essential to follow the specific instructions provided by the prescribing healthcare professional. Tazemetostat is typically available in the form of oral tablets, and the dosage and administration instructions may vary based on the individual patient and the type of cancer being treated. Here are some general guidelines:

  • Dosage: The recommended dosage of Tazemetostat can vary, and it is determined by the healthcare provider based on factors such as the patient’s weight, overall health, and the specific type of cancer being treated. The tablets are usually taken orally with or without food.
  • Administration: Swallow the tablet whole with a glass of water; do not crush, chew, or break the tablet unless advised otherwise by the healthcare provider.
  • Schedule: Tazemetostat is often taken once or twice daily, and the specific dosing schedule will be determined by the healthcare provider.
  • Compliance: It is crucial to adhere to the prescribed dosage and schedule consistently to ensure the effectiveness of the treatment.
  • Monitoring: Regular medical check-ups and laboratory tests may be scheduled to monitor the patient’s response to Tazemetostat and assess for any potential side effects.
  • Side Effects and Concerns: Report any side effects or concerns to the healthcare provider promptly. Common side effects may include fatigue, nausea, vomiting, decreased appetite, and changes in blood cell counts. However, individual experiences can vary.

Always consult with the prescribing healthcare professional or refer to the medication’s official prescribing information for the most accurate and up-to-date instructions. If you have specific questions or concerns about Tazemetostat, it’s best to discuss them directly with the healthcare provider overseeing your treatment.

Other uses for this medicine

As of last update, Tazemetostat’s primary approved use is for epithelioid sarcoma. However, ongoing research and clinical trials may explore its potential effectiveness in other types of cancers or medical conditions. It’s essential to consult with healthcare professionals or refer to the latest medical literature for the most up-to-date information on additional uses for Tazemetostat.

What special precautions should I follow?

Regarding special precautions for Tazemetostat, it is crucial to follow the guidance provided by the prescribing healthcare provider. Here are some general considerations:

  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The potential risks and benefits of Tazemetostat during pregnancy or breastfeeding should be discussed.
  • Liver Function: Tazemetostat may affect liver function, and regular monitoring of liver function tests may be necessary during treatment.
  • Drug Interactions: Inform your healthcare provider about all medications, including prescription, over-the-counter, and herbal supplements, that you are taking. Tazemetostat may interact with certain medications.
  • Side Effects: Be aware of potential side effects, and promptly report any unusual symptoms or adverse reactions to your healthcare provider.
  • Regular Monitoring: Regular medical check-ups and laboratory tests may be scheduled to monitor your overall health and response to treatment.
  • Allergies: Inform your healthcare provider about any known allergies or hypersensitivity to medications.

It is essential to communicate openly with your healthcare provider about your medical history, current medications, and any concerns you may have. Your healthcare team will provide personalized guidance based on your specific situation. Always follow the prescribed dosage and administration instructions, and do not hesitate to ask questions if you need clarification or additional information.

What special dietary instructions should I follow?

There are no specific dietary restrictions or instructions associated with Tazemetostat. However, it’s important to follow a balanced and nutritious diet to support your overall health during cancer treatment. If you have specific concerns or questions about your diet while taking Tazemetostat, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Tazemetostat, it’s important to follow these general guidelines:

  • Timing: Take the missed dose as soon as you remember, but skip it if it is almost time for the next scheduled dose.
  • Double Dosing: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can increase the risk of side effects.
  • Contact Healthcare Provider: If you are unsure about what to do or if you have missed multiple doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Tazemetostat, like any medication, can cause side effects. It’s important to note that the severity and specific side effects can vary from person to person, and not everyone will experience them. If you have been prescribed Tazemetostat, your healthcare provider will discuss the potential side effects with you. Common side effects and adverse reactions associated with Tazemetostat may include:

  • Fatigue: Feeling tired or weak.
  • Nausea: A feeling of discomfort or queasiness in the stomach.
  • Vomiting: The forceful expulsion of stomach contents through the mouth.
  • Decreased Appetite: A reduced desire to eat.
  • Constipation: Difficulty passing stools.
  • Diarrhea: Loose or watery stools.
  • Muscle Pain: Aching or discomfort in the muscles.
  • Abdominal Pain: Pain or discomfort in the abdominal area.
  • Changes in Blood Cell Counts: Tazemetostat may affect blood cell counts, leading to an increased risk of infection, anemia, or bleeding.
  • Changes in Liver Function: Tazemetostat may impact liver function, and liver enzyme levels may need monitoring.

It’s important to promptly report any unusual or severe symptoms to your healthcare provider. Additionally, there may be other, less common side effects not listed here. Always consult the prescribing information provided with the medication or speak directly with your healthcare team for comprehensive details.

If you experience serious side effects, such as difficulty breathing, chest pain, severe abdominal pain, or any signs of an allergic reaction (e.g., rash, itching, swelling, severe dizziness), seek immediate medical attention.

Remember, this information is based on last update, and there may be new developments or information since then. Always consult with your healthcare provider for the most up-to-date and personalized information regarding Tazemetostat and its potential side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Tazemetostat:


  • Temperature: Store Tazemetostat at room temperature, away from extreme heat or cold.
  • Container: Keep the medication in its original container, and ensure that the container is tightly closed.
  • Light: Protect Tazemetostat from excessive light exposure.
  • Location: Store the medication in a safe place, out of reach of children and pets.


  • Follow Local Regulations: Dispose of Tazemetostat according to local regulations for medication disposal. Some regions have specific guidelines to prevent environmental contamination.
  • Community Take-Back Programs: Check for community drug take-back programs or facilities that accept unused medications.
  • Pharmacy or Healthcare Provider: Consult with your pharmacist or healthcare provider for guidance on proper disposal methods.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek immediate medical attention. Contact your local poison control center (in the United States, you can call 1-800-222-1222) or go to the nearest emergency room.

What other information should I know?

  • Follow Healthcare Provider’s Instructions: Take Tazemetostat exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting them.
  • Regular Monitoring: Attend scheduled follow-up appointments and laboratory tests as recommended by your healthcare provider.
  • Inform Healthcare Provider: Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, that you are taking.
  • Report Side Effects: Report any side effects or concerns to your healthcare provider promptly.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider before starting Tazemetostat.

Always consult the prescribing information and your healthcare provider for the most accurate and personalized information regarding Tazemetostat and its use. This information is based on knowledge, and there may be updates or changes.

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