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Takhzyro (Generic Lanadelumab-flyo injection)

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Why is this medication prescribed?

Takhzyro is a medication prescribed for the prevention of hereditary angioedema (HAE) attacks in individuals aged 12 years and older. Hereditary angioedema is a rare genetic disorder that results in recurrent episodes of severe swelling in various parts of the body, including the hands, feet, face, and airways.

Takhzyro belongs to a class of drugs called monoclonal antibodies. It works by inhibiting the activity of a protein called plasma kallikrein, which is involved in the production of bradykinin. Bradykinin is a substance that can lead to the symptoms of hereditary angioedema, including swelling.

How should this medicine be used?

Here are general guidelines on how Takhzyro is typically used:

  • Dosage: The recommended dosage of Takhzyro is usually determined by the healthcare provider based on factors such as the patient’s age, weight, and the frequency of HAE attacks.
  • Administration: Takhzyro is given as a subcutaneous (under the skin) injection. Patients are often trained on how to self-administer the injections or may have a caregiver assist them.
  • Frequency: The frequency of Takhzyro injections depends on the prescribed dose and the individual’s specific treatment plan. It may be administered every two weeks or less frequently, as determined by the healthcare provider.
  • Site of Injection: Takhzyro injections are typically administered into the fatty tissue just under the skin. Common injection sites include the abdomen or thigh. It’s important to rotate injection sites to reduce the risk of injection site reactions.
  • Monitoring: Patients should follow their healthcare provider’s instructions carefully and attend regular follow-up appointments to monitor their response to the medication and adjust the treatment plan if needed.

It’s crucial for individuals prescribed Takhzyro to follow their healthcare provider’s recommendations closely and report any concerns, side effects, or changes in symptoms promptly. As with any medication, the specific instructions may vary, so individuals should consult with their healthcare provider for personalized guidance based on their medical history and condition.

Other uses for this medicine

As for other uses, it’s important to note that medications are typically approved for specific indications based on clinical trials and regulatory approvals. Any use of Takhzyro beyond its approved indication should be discussed with and approved by a healthcare professional.

What special precautions should I follow?

Regarding special precautions for Takhzyro, it’s essential to follow the guidance provided by your healthcare provider. Here are some general considerations:

  • Allergies: Inform your healthcare provider about any known allergies or hypersensitivity to lanadelumab or any other ingredients in Takhzyro.
  • Pregnancy and Breastfeeding: The safety of Takhzyro during pregnancy and breastfeeding is not well-established. Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
  • Infections: Takhzyro may increase the risk of infections. Report any signs of infection, such as fever or persistent sore throat, to your healthcare provider.
  • Monitoring: Regular monitoring and follow-up with your healthcare provider are essential to assess the effectiveness of the treatment and manage any potential side effects.
  • Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as Takhzyro may interact with other drugs.
  • Injection Site Reactions: Takhzyro is administered by subcutaneous injection. Be aware of potential injection site reactions and report any unusual or severe reactions to your healthcare provider.
  • Medical History: Provide your healthcare provider with a comprehensive medical history, including any pre-existing conditions or a history of hypersensitivity reactions.

It’s important to remember that the information provided here is based on available knowledge, and there may have been developments or updates since then. Always consult with your healthcare provider for the most current and personalized information related to your health and the use of Takhzyro.

What special dietary instructions should I follow?

There are typically no specific dietary restrictions associated with Takhzyro. However, it’s important to maintain a healthy and balanced diet as part of overall well-being. If you have any concerns or specific dietary considerations, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Takhzyro, contact your healthcare provider for guidance. It’s important not to double the dose to make up for a missed one. Your healthcare provider may provide instructions on when to take the next dose or make adjustments to your treatment plan.

What side effects can this medication cause?

Takhzyro (lanadelumab) may cause side effects, and it’s important to be aware of them. Common side effects are generally mild, but serious side effects can occur. Remember to contact your healthcare provider if you experience any side effects, especially if they are severe or persistent. Common side effects may include:

  • Injection Site Reactions: Redness, swelling, or pain at the injection site are common reactions. Rotating injection sites as recommended may help minimize these reactions.
  • Upper Respiratory Tract Infection: Symptoms such as nasal congestion, sore throat, and sinus congestion may occur.
  • Headache: Some individuals may experience headaches.

Serious side effects are less common but may include:

  • Hypersensitivity Reactions: Allergic reactions, including rash, itching, and swelling of the face, lips, or tongue, may occur. Severe hypersensitivity reactions are rare but can be serious.
  • Thrombotic Events: There have been reports of thrombotic events (blood clots) in patients receiving Takhzyro. Seek medical attention if you experience symptoms such as chest pain, shortness of breath, or swelling in the legs.
  • Hypersensitivity Angioedema: In rare cases, Takhzyro may cause hypersensitivity angioedema, which can be severe. Symptoms may include swelling of the face, lips, tongue, throat, or extremities, and difficulty breathing.

It’s important to note that this is not an exhaustive list, and individual reactions may vary. Always consult with your healthcare provider for the most up-to-date information on potential side effects associated with Takhzyro. If you experience any adverse effects, contact your healthcare provider promptly for guidance.

What should I know about storage and disposal of this medication?

Here are some important considerations regarding the storage and disposal information related to Takhzyro:


  • Store Takhzyro as directed by your healthcare provider or as per the instructions provided in the medication packaging.
  • Takhzyro is typically stored in the refrigerator. Follow specific storage instructions to ensure the stability and effectiveness of the medication.
  • Do not freeze Takhzyro. If it accidentally freezes, consult with your healthcare provider or pharmacist.


  • Dispose of Takhzyro as directed by your healthcare provider or follow local regulations for medication disposal.
  • Do not dispose of Takhzyro in household trash unless specifically instructed to do so.
  • If you have questions about proper disposal, consult your healthcare provider or pharmacist.

In case of emergency/overdose

In case of emergency or if you suspect an overdose, seek immediate medical attention or contact your local poison control center. Overdose symptoms or severe adverse reactions may require prompt medical intervention.

What other information should I know?

  • Keep a record of your Takhzyro injections, noting the date, time, and injection site. This information can be helpful for both you and your healthcare provider.
  • Attend all scheduled appointments with your healthcare provider to monitor your response to the medication and make any necessary adjustments to your treatment plan.
  • Inform all healthcare providers involved in your care that you are using Takhzyro. This includes dentists, emergency room staff, and specialists.
  • Carry an emergency identification card or wear a medical alert bracelet to inform healthcare providers about your use of Takhzyro in case of emergencies.

Always follow your healthcare provider’s instructions and guidelines for the use, storage, and disposal of Takhzyro. If you have any questions or concerns, do not hesitate to reach out to your healthcare provider or pharmacist for clarification. This information is based on general guidelines, and specific recommendations may vary based on individual circumstances and healthcare provider instructions.

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