Why is this medication prescribed?

Tagrisso (osimertinib) is a prescription medication used for the treatment of certain types of non-small cell lung cancer (NSCLC). Specifically, it is indicated for the treatment of patients with metastatic NSCLC whose tumors have epidermal growth factor receptor (EGFR) mutations, particularly those with the T790M mutation.

EGFR mutations play a role in the development and growth of some types of lung cancers. Tagrisso is an EGFR tyrosine kinase inhibitor, which means it works by blocking the activity of the EGFR protein, inhibiting the growth of cancer cells.

How should this medicine be used?

Tagrisso (osimertinib) is an oral medication used for the treatment of non-small cell lung cancer (NSCLC) with specific epidermal growth factor receptor (EGFR) mutations. Here are general guidelines for how Tagrisso should be used:

• Dosage: The recommended dosage of Tagrisso can vary based on individual patient factors and the specific details of their condition. Always follow the dosage instructions provided by the prescribing healthcare professional.
• Administration: Tagrisso is taken orally, usually in the form of tablets. The tablets should be swallowed whole with a glass of water. It is important not to crush or break the tablets.
• Timing: Tagrisso can be taken with or without food. The healthcare provider will specify the appropriate schedule for taking the medication.
• Missed Dose: If a dose is missed, patients should take the missed dose as soon as they remember, unless it is close to the time of the next scheduled dose. In such cases, patients should skip the missed dose and resume their regular dosing schedule. It’s crucial to inform the healthcare provider about any missed doses.
• Follow-up: Regular follow-up appointments with the healthcare team are essential to monitor the patient’s response to treatment, manage any side effects, and make any necessary adjustments to the treatment plan.
• Side Effects: Patients should be aware of potential side effects and report any unusual or severe symptoms to their healthcare provider promptly. Common side effects may include diarrhea, rash, dry skin, and changes in liver function.
• Duration of Treatment: The duration of Tagrisso treatment will depend on the individual patient’s response to the medication and the overall management plan for their lung cancer. It’s important not to stop taking Tagrisso without consulting the healthcare provider, even if the patient feels better.
• Pregnancy and Contraception: Tagrisso may cause harm to a developing fetus, so it’s important to use effective contraception during treatment and for some time after the last dose. Patients should discuss family planning with their healthcare provider.

Always follow the specific instructions and recommendations provided by the prescribing healthcare professional. The information here is a general guideline, and individual circumstances may warrant different approaches to treatment. If there are any questions or concerns about the use of Tagrisso, it’s crucial to consult with the healthcare team for personalized advice.

Other uses for this medicine

Tagrisso (osimertinib) is primarily approved for the treatment of non-small cell lung cancer (NSCLC) with specific epidermal growth factor receptor (EGFR) mutations. Tagrisso has not been approved for other uses beyond this indication. It’s important to note that the information provided here may be subject to updates or changes, so it’s advisable to consult with a healthcare professional or refer to the latest medical literature for the most current information.

What special precautions should I follow?

Special precautions and considerations for the use of Tagrisso include:

• EGFR Mutation Testing: Tagrisso is specifically indicated for patients with metastatic NSCLC whose tumors have EGFR mutations, particularly the T790M mutation. Before starting Tagrisso, it is important to confirm the presence of these mutations through appropriate diagnostic testing.
• Pregnancy and Contraception: Tagrisso may cause harm to a developing fetus. Therefore, it is important for individuals of reproductive potential to use effective contraception during treatment and for some time after the last dose. Pregnant individuals or those planning to become pregnant should discuss the risks and benefits with their healthcare provider.
• Liver Function Monitoring: Tagrisso can affect liver function, and regular monitoring of liver function tests is typically recommended during treatment. Any signs of liver problems, such as jaundice (yellowing of the skin or eyes), dark urine, or abdominal pain, should be reported to the healthcare provider.
• Interstitial Lung Disease (ILD): ILD, including pneumonitis, has been reported with Tagrisso. Patients should be monitored for symptoms such as cough, difficulty breathing, or fever, and treatment should be interrupted or discontinued if ILD is suspected.
• QT Interval Prolongation: Tagrisso can cause QT interval prolongation, which may lead to an increased risk of irregular heart rhythms. Patients with a history of QT interval prolongation, electrolyte abnormalities, or those taking medications that can prolong the QT interval should be monitored closely.
• Drug Interactions: Tagrisso can interact with other medications, including those that are metabolized by certain enzymes in the liver. Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking.
• Hypersensitivity Reactions: Hypersensitivity reactions, including rash and anaphylaxis, have been reported with Tagrisso. Patients should seek medical attention if they experience severe allergic reactions.

It is crucial for patients to discuss their medical history, current medications, and any concerns with their healthcare provider before starting Tagrisso. Additionally, individuals should receive regular monitoring and follow-up to manage potential side effects and assess treatment response. Always follow the specific instructions and precautions provided by the prescribing healthcare professional.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Tagrisso. However, it’s essential to maintain a well-balanced and nutritious diet to support overall health during cancer treatment. If there are any updates or changes to dietary recommendations, your healthcare provider will provide specific guidance.

What should I do if I forget a dose?

If you forget to take a dose of Tagrisso, follow these general guidelines:

• If it is within 6 hours of the missed dose: Take the missed dose as soon as you remember. If the next scheduled dose is less than 6 hours away, skip the missed dose and take the next dose at the regular time.
• If it is more than 6 hours since the missed dose: Skip the missed dose and take the next dose at the regular time.

What side effects can this medication cause?

Tagrisso (osimertinib) may cause various side effects, and it’s important for individuals taking this medication to be aware of potential adverse reactions. Keep in mind that not everyone will experience these side effects, and their severity can vary. Common side effects of Tagrisso may include:

• Gastrointestinal Effects:
  • Diarrhea
  • Nausea
  • Vomiting
  • Decreased appetite
  • Constipation
• Skin and Nail Changes:
  • Rash (may be acne-like or more generalized)
  • Dry skin
  • Itchy skin
  • Changes in the nails (e.g., brittle nails)
• Respiratory Effects:
  • Cough
  • Shortness of breath
  • Interstitial lung disease (ILD), including pneumonitis (inflammation of the lung tissue)
• Cardiovascular Effects:
  • QT interval prolongation (may increase the risk of irregular heart rhythms)
• Liver Function Abnormalities:
  • Elevated liver enzymes (as seen in liver function tests)
  • Hepatitis (inflammation of the liver)
• Ocular Effects:
  • Eye disorders, such as dry eyes or blurred vision
• Fatigue:
  • Generalized weakness or tiredness
• Other Effects:
  • Muscle pain
  • Joint pain
  • Headache
  • Infections (upper respiratory tract infections)

It’s important to note that this is not an exhaustive list, and other side effects may occur. Additionally, individual responses to medication can vary, and some individuals may experience side effects not listed here.

Patients should promptly report any unusual or severe symptoms to their healthcare provider. It’s crucial to attend regular follow-up appointments so that healthcare professionals can monitor for potential side effects, assess treatment response, and make any necessary adjustments to the treatment plan.

In some cases, the healthcare provider may need to adjust the dosage, temporarily interrupt treatment, or consider other interventions to manage side effects. If you are taking Tagrisso or any other medication, consult with your healthcare team for personalized information and guidance based on your specific health status and medical history.

What should I know about storage and disposal of this medication?

Storage and Disposal of Tagrisso:

• Storage: Tagrisso (osimertinib) should be stored at room temperature between 20°C to 25°C (68°F to 77°F). Keep the medication in its original container, away from light, moisture, and heat. Do not store it in the bathroom.
• Keep Out of Reach of Children: Store Tagrisso in a location that is out of reach of children and pets.
• Do Not Share Medication: Tagrisso is prescribed specifically for the individual patient. Do not share it with others, even if they have similar symptoms or conditions.
• Disposal: Follow local regulations and guidelines for the proper disposal of unused or expired medications. Do not flush Tagrisso down the toilet or pour it down the drain unless instructed to do so.

In case of emergency/overdose

In the event of a suspected overdose or emergency, seek medical attention or contact your local poison control center immediately. The symptoms of an overdose may include an increased risk of side effects, such as gastrointestinal symptoms, skin reactions, and potential complications related to the cardiovascular or respiratory systems.

What other information should I know?

• Regular Follow-Up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. Regular monitoring is essential to assess the effectiveness of treatment, manage potential side effects, and make any necessary adjustments to the treatment plan.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care about your use of Tagrisso, including dentists and pharmacists. This information is important in case of any potential drug interactions or complications.
• Blood Tests: Your healthcare provider may order blood tests to monitor your liver function and other parameters. Attend these appointments as recommended.
• Contraception: If you are of reproductive potential, use effective contraception during treatment with Tagrisso and for a certain period after the last dose. Discuss family planning with your healthcare provider.
• Allergic Reactions: Seek medical attention immediately if you experience signs of a severe allergic reaction, such as difficulty breathing, swelling of the face or throat, or severe rash.
• Inform About Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential drug interactions.
• Patient Assistance Programs: If you are having difficulty affording your medication, inquire about patient assistance programs that may be available to provide financial assistance.

Always follow your healthcare provider’s instructions and recommendations. If you have any questions or concerns about Tagrisso or your treatment plan, consult with your healthcare team for personalized advice.