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Tafasitamab-cxix Injection

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Why is this medication prescribed?

Tafasitamab-cxix is a prescription medication used for the treatment of certain types of non-Hodgkin lymphoma. Specifically, it is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), a type of aggressive lymphoma. Tafasitamab-cxix is often prescribed in combination with lenalidomide for this indication.

The combination of tafasitamab-cxix with lenalidomide is typically used in patients who have not responded to, or have relapsed after, at least two prior lines of systemic therapy.

How should this medicine be used?

Tafasitamab-cxix is typically administered as an intravenous (IV) infusion. Here is a general overview of the administration process:

  • Healthcare Setting: Tafasitamab-cxix is usually administered in a healthcare setting, such as a hospital, clinic, or infusion center. The infusion is carried out under the supervision of trained healthcare professionals.
  • Dosage: The dosage of Tafasitamab-cxix can vary, and the healthcare provider will determine the appropriate dose for each patient based on factors such as the type and stage of lymphoma and the patient’s overall health.
  • Frequency of Administration: The frequency of Tafasitamab-cxix infusions will also be determined by the healthcare provider. It is administered in cycles, and the treatment plan may involve multiple cycles depending on the response to the medication.
  • Preparation and Administration: The medication is prepared and administered by a healthcare professional. It is typically given as an intravenous infusion over a specified period of time. The infusion process allows the medication to enter the bloodstream and reach the targeted cells.
  • Monitoring: Patients receiving Tafasitamab-cxix are closely monitored during and after the infusion for any potential side effects or reactions. The healthcare team will take necessary precautions to address any adverse effects that may occur.

It’s important to communicate openly with the healthcare team about any concerns, side effects, or changes in health during the course of treatment. Additionally, patients should adhere to the prescribed schedule and not adjust or stop the medication without consulting their healthcare provider.

Since medical information may have changed since last update, it’s essential to consult with a healthcare professional or refer to the most recent sources for the latest and most accurate information on the use of Tafasitamab-cxix Injection.

Other uses for this medicine

Tafasitamab-cxix is primarily indicated for the treatment of DLBCL. Its use for other conditions would be determined by your healthcare provider based on individual circumstances.

What special precautions should I follow?

In terms of special precautions, it’s important to consider the following:

  • Medical History: Before starting Tafasitamab-cxix, inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or medications you are currently taking.
  • Pregnancy and Breastfeeding: Tafasitamab-cxix may have potential risks to a developing fetus, so it’s important to inform your healthcare provider if you are pregnant or planning to become pregnant. Breastfeeding should be avoided during treatment and for a certain period after the last dose.
  • Infections: Tafasitamab-cxix can increase the risk of infections. Inform your healthcare provider if you have a history of infections or if you develop signs of infection during treatment, such as fever or persistent cough.
  • Infusion Reactions: Infusion-related reactions, such as fever, chills, and low blood pressure, can occur during or after the infusion. Healthcare providers usually take precautions to minimize these reactions.
  • Monitoring: Regular monitoring of blood counts and other laboratory parameters may be necessary during treatment to assess the impact of Tafasitamab-cxix on the body.

It is essential to follow the specific guidance provided by your healthcare provider and adhere to the prescribed treatment plan. If you have any concerns or questions about Tafasitamab-cxix or its potential uses, it’s recommended to discuss them directly with your healthcare team for personalized information based on your health status and medical history.

What special dietary instructions should I follow?

There were no specific dietary restrictions associated with Tafasitamab-cxix. However, dietary recommendations may be subject to change, and it’s crucial to consult with your healthcare provider for the most up-to-date information.

What should I do if I forget a dose?

If you forget a dose of Tafasitamab-cxix, it is important to contact your healthcare provider or medical team immediately for guidance. They will provide specific instructions on how to proceed, which may involve rescheduling the missed dose or adjusting the treatment plan. Do not attempt to adjust your dosage without consulting your healthcare provider.

What side effects can this medication cause?

Tafasitamab-cxix (brand name Monjuvi) is associated with potential side effects, and it’s important for patients to be aware of these and promptly report any unusual symptoms to their healthcare provider. It’s essential to note that individual experiences with medication can vary, and not everyone will experience the same side effects. Common side effects, as well as less common but more severe reactions, may include:

Common Side Effects:

  • Infusion-related reactions: These can include fever, chills, nausea, headache, low blood pressure, and difficulty breathing. These reactions typically occur during or shortly after the infusion and are closely monitored by healthcare professionals.
  • Fatigue: Feeling tired or weak is a common side effect of many cancer treatments, including Tafasitamab-cxix.
  • Upper respiratory tract infections: Symptoms may include nasal congestion, sore throat, cough, and sinusitis.
  • Diarrhea: Some patients may experience diarrhea as a side effect of Tafasitamab-cxix.
  • Constipation: Constipation may occur as a side effect.
  • Decreased appetite: Some patients may experience a reduced desire to eat.

Less Common but Potentially Serious Side Effects:

  • Infections: Tafasitamab-cxix may increase the risk of infections, and serious infections can occur. Patients should promptly report any signs of infection, such as fever or persistent cough.
  • Hepatitis B virus reactivation: Tafasitamab-cxix may lead to the reactivation of hepatitis B in individuals who are carriers of the virus.
  • Tumor lysis syndrome: This is a rare but serious complication that can occur when cancer cells break down rapidly, releasing their contents into the bloodstream. It may lead to metabolic imbalances.
  • Cytopenias: Tafasitamab-cxix can cause a decrease in blood cell counts, including white blood cells, red blood cells, and platelets.
  • Serious skin reactions: Some patients may experience severe skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis.

It’s crucial for patients to communicate openly with their healthcare team about any side effects they experience during Tafasitamab-cxix treatment. The healthcare provider will monitor for potential complications and may adjust the treatment plan if necessary.

This information is based on knowledge, and there may have been updates or changes since then. Always consult with your healthcare provider or refer to the most recent prescribing information for the latest details on Tafasitamab-cxix and its potential side effects.

What should I know about storage and disposal of this medication?

Here are some general points to consider:


  • Tafasitamab-cxix is typically administered in a healthcare setting under the supervision of trained healthcare professionals. Therefore, the storage of the medication is usually managed by the healthcare facility.
  • In case you are provided with any take-home supplies or have specific instructions, it’s crucial to store the medication as directed by your healthcare provider or pharmacist. Follow any temperature and storage requirements mentioned in the product labeling.
  • Avoid freezing the medication. If the medication needs to be refrigerated, do not freeze it.
  • Keep the medication out of the reach of children and pets.


  • Dispose of Tafasitamab-cxix as directed by your healthcare provider, pharmacist, or local waste disposal regulations.
  • Do not dispose of medications in household trash unless specifically instructed to do so. Instead, follow any specific disposal instructions provided, such as returning unused medications to a healthcare facility or using a drug take-back program.
  • If you are unsure about the proper disposal method, consult with your healthcare provider or pharmacist for guidance.

In case of emergency/overdose

In the event of an emergency or suspected overdose, seek immediate medical attention. Contact your local poison control center at 1-800-222-1222 (in the United States) for guidance. It’s essential to provide as much information as possible, including the name of the medication (Tafasitamab-cxix), the dosage, and the time of ingestion.

What other information should I know?

  • Keep a list of all medications you are currently taking, including prescription and over-the-counter drugs, as well as any herbal supplements or vitamins. Share this list with your healthcare provider to avoid potential drug interactions.
  • Attend all scheduled medical appointments and laboratory tests as recommended by your healthcare provider to monitor your response to Tafasitamab-cxix and to detect any potential side effects or complications.
  • Inform your healthcare provider about any allergies, medical conditions, or changes in your health status during the course of treatment.
  • If you have questions or concerns about Tafasitamab-cxix, its administration, or any side effects, discuss them with your healthcare provider for clarification and guidance.

Always follow the specific instructions provided by your healthcare team and refer to the most recent prescribing information for Tafasitamab-cxix for the latest and most accurate details.

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