WARNING

Rinvoq, also known as upadacitinib, is a medication used to treat certain autoimmune conditions, such as rheumatoid arthritis. Like any medication, Rinvoq comes with potential risks and side effects. It’s essential to note that the information provided here is not a substitute for professional medical advice, and individuals should consult their healthcare provider for personalized guidance. Here are some potential risks associated with Rinvoq:

• Infections: Rinvoq may increase the risk of serious infections, including bacterial, fungal, and viral infections. It is important to monitor for signs of infection and report any symptoms to a healthcare professional promptly.
• Risk of Tuberculosis (TB): There is an increased risk of tuberculosis in individuals taking Rinvoq. Prior to starting treatment, patients may undergo testing for latent tuberculosis, and appropriate treatment may be initiated if necessary.
• Malignancies: There may be a higher risk of certain cancers, including lymphoma, with the use of Rinvoq. Regular monitoring and screening for malignancies may be recommended.
• Gastrointestinal Perforations: There have been reports of gastrointestinal perforations in patients taking Rinvoq. Individuals with a history of diverticulitis or other gastrointestinal issues may be at a higher risk.
• Blood Clotting: Rinvoq may increase the risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism. Patients with a history of blood clots or those at an increased risk should be monitored closely.
• Liver Enzyme Elevations: Elevated liver enzymes have been reported in some patients taking Rinvoq. Regular monitoring of liver function may be necessary.
• Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis, may occur in some individuals. It is crucial to seek immediate medical attention if signs of a severe allergic reaction develop.
• Lipid Changes: Rinvoq may lead to changes in lipid levels, including increases in cholesterol levels. Monitoring and management of lipid levels may be recommended.
• Bone Marrow Suppression: Rinvoq may cause decreases in blood cell counts, including red blood cells, white blood cells, and platelets. Regular blood tests may be conducted to monitor for these changes.

It’s essential for individuals considering or taking Rinvoq to have a thorough discussion with their healthcare provider about their medical history, potential risks, and benefits of the medication. Healthcare professionals will monitor patients closely and adjust treatment plans as needed to minimize risks and optimize outcomes.

Why is this medication prescribed?

Rinvoq (upadacitinib) is prescribed for the treatment of certain autoimmune conditions, particularly moderate to severe rheumatoid arthritis in adults. Rheumatoid arthritis is a chronic inflammatory disorder that affects the joints, causing pain, swelling, and stiffness. Rinvoq belongs to a class of medications known as Janus kinase (JAK) inhibitors, which work by targeting and inhibiting specific enzymes involved in the inflammatory process.

How should this medicine be used?

Rinvoq (upadacitinib) is a prescription medication used to treat moderate to severe rheumatoid arthritis in adults. It is a Janus kinase (JAK) inhibitor that helps reduce inflammation and slow down the progression of the disease. However, it’s important to note that only a qualified healthcare professional can prescribe and guide the use of Rinvoq based on an individual’s specific health condition.

Here are general guidelines for using Rinvoq, but remember to follow your doctor’s instructions precisely:

• Dosage: Rinvoq is available in tablet form. The typical starting dose is 15 mg once daily.
• Timing: Rinvoq is usually taken with or without food. Follow the prescribed dosing schedule provided by your healthcare provider.
• Regular Monitoring: Your doctor may monitor your response to the medication and adjust the dosage as needed. Regular follow-up appointments and lab tests may be required to check for potential side effects or changes in your health.
• Compliance: Take Rinvoq exactly as prescribed by your doctor. If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed one and continue with your regular schedule.
• Side Effects: Be aware of potential side effects and report any unusual symptoms to your healthcare provider promptly. Common side effects may include upper respiratory tract infections, high blood pressure, and changes in certain blood tests.
• Precautions: Inform your doctor of any pre-existing medical conditions or medications you are taking, as they may impact the suitability of Rinvoq for you. Let your healthcare provider know if you have a history of serious infections or if you are prone to infections.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Rinvoq with your healthcare provider.

Always consult your healthcare professional for personalized advice on the use of Rinvoq based on your specific health status and needs. It’s crucial to have open communication with your doctor to ensure the safest and most effective use of this medication.

Other uses for this medicine

Rinvoq (upadacitinib) is primarily approved for the treatment of moderate to severe rheumatoid arthritis in adults who have not responded adequately to other disease-modifying antirheumatic drugs (DMARDs). It’s important to note that new uses or indications for medications may have been approved since then, so it’s advisable to check with a healthcare professional or refer to the most recent prescribing information for the latest updates.

What special precautions should I follow?

As for special precautions associated with Rinvoq, it’s crucial for individuals to be aware of certain considerations and follow healthcare provider guidance closely. Here are some general precautions:

• Infections: Rinvoq may increase the risk of serious infections. Before starting treatment, healthcare providers may assess the patient’s infection history and perform screening for latent tuberculosis. Patients should be vigilant about signs of infection and report them promptly.
• Vaccinations: It’s recommended to bring vaccinations up to date before starting Rinvoq. However, live vaccines should be avoided during treatment, as Rinvoq may affect the immune system’s response.
• Blood Clots: Rinvoq may increase the risk of blood clots. Individuals with a history of blood clots or conditions predisposing them to clotting should be monitored closely.
• Gastrointestinal Perforations: There have been reports of gastrointestinal perforations in patients taking Rinvoq, particularly in those with a history of diverticulitis. Caution is advised in individuals with gastrointestinal issues.
• Liver Function: Rinvoq may affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function is typically recommended.
• Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis, have been reported. Individuals should seek immediate medical attention if they experience signs of a severe allergic reaction.
• Pregnancy and Breastfeeding: The safety of Rinvoq during pregnancy and breastfeeding is not well-established. Pregnant or breastfeeding individuals should discuss potential risks and benefits with their healthcare provider.
• Hematological Abnormalities: Rinvoq may cause decreases in blood cell counts, including red blood cells, white blood cells, and platelets. Regular blood tests are usually conducted to monitor for these changes.
• Bone Density: Some JAK inhibitors, including Rinvoq, may be associated with changes in bone density. Bone health should be monitored, especially in individuals at risk for osteoporosis.

Patients should communicate openly with their healthcare provider about their medical history, including any pre-existing conditions or medications they are taking. The decision to use Rinvoq involves a careful evaluation of the potential benefits and risks, and it should be made collaboratively between the patient and their healthcare team. Regular follow-up appointments and ongoing monitoring are essential to ensure the medication’s safety and efficacy.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with Rinvoq. However, it’s essential to maintain a healthy and balanced diet to support overall well-being. If you have specific dietary concerns or restrictions, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Rinvoq, follow these general guidelines:

• Timing: Take the missed dose as soon as you remember, unless it’s almost time for the next scheduled dose.
• Double Dose: Do not take a double dose to make up for a missed one. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.
• Consult Your Healthcare Provider: If you have questions or concerns about missed doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Rinvoq (upadacitinib) is associated with a range of potential side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Additionally, the information provided here is not exhaustive, and individuals should consult their healthcare provider for a comprehensive understanding of potential side effects. Common side effects of Rinvoq include:

• Upper Respiratory Tract Infections: These can include symptoms such as nasal congestion, sore throat, and sinus infections.
• High Blood Pressure: Some individuals may experience an increase in blood pressure while taking Rinvoq.
• Headache: Headaches are a common side effect reported by individuals using Rinvoq.
• Increased Liver Enzymes: Rinvoq may lead to elevated liver enzyme levels, which are typically monitored through blood tests.
• Changes in Blood Cell Counts: Rinvoq may cause decreases in red blood cells, white blood cells, and platelets, which can be detected through regular blood tests.
• Increased Cholesterol Levels: Some individuals may experience elevated cholesterol levels while taking Rinvoq.
• Gastrointestinal Symptoms: These can include nausea, abdominal pain, and diarrhea.
• Herpes Zoster (Shingles): There is an increased risk of developing shingles in individuals taking Rinvoq.
• Risk of Serious Infections: Rinvoq may increase the risk of serious infections, including bacterial, fungal, and viral infections.
• Risk of Blood Clots: There is an increased risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism.
• Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis, have been reported in some cases.
• Gastrointestinal Perforations: Rare cases of gastrointestinal perforations have been reported.

It’s crucial for individuals taking Rinvoq to be aware of these potential side effects and promptly report any unusual or severe symptoms to their healthcare provider. Additionally, regular monitoring through blood tests and follow-up appointments is typically recommended to detect and manage potential side effects. The decision to use Rinvoq involves a careful evaluation of the potential benefits and risks, and healthcare providers work closely with patients to optimize treatment while minimizing side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Rinvoq:

• Rinvoq should be stored at room temperature, away from excessive heat and moisture.
• Keep the medication in its original packaging to protect it from light.
• Do not store Rinvoq in the bathroom or in places where it might be exposed to moisture.
• Keep Rinvoq out of the reach of children and pets.

Regarding disposal:

• Follow local regulations and guidelines for the proper disposal of medication.
• Do not flush Rinvoq down the toilet or pour it down the drain unless instructed to do so by your healthcare provider or local authorities.
• If you have questions about how to dispose of Rinvoq, consult with your healthcare provider or pharmacist.

In case of emergency/overdose

• In case of an overdose or if you suspect someone has taken more Rinvoq than prescribed, seek emergency medical attention immediately.
• Contact your local poison control center or emergency room for guidance.

What other information should I know?

• Regular Monitoring: Attend regular follow-up appointments with your healthcare provider for monitoring.
• Lab Tests: Your doctor may order periodic blood tests to monitor the effects of Rinvoq and check for potential side effects.
• Inform Healthcare Providers: Inform all healthcare providers (including dentists and surgeons) about your Rinvoq use before undergoing any medical procedures or surgeries.
• Infections: Be cautious about the risk of infections. Contact your healthcare provider if you experience signs of infection, such as fever, persistent cough, or flu-like symptoms.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as Rinvoq may have implications.

Always follow your healthcare provider’s instructions and consult them if you have any concerns or questions about Rinvoq. Individual health conditions can vary, and your doctor is best positioned to provide personalized advice based on your specific circumstances.