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Retevmo (Generic Selpercatinib)

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Why is this medication prescribed?

Retevmo (selpercatinib) is a prescription medication used to treat certain types of cancer. It is specifically indicated for the treatment of:

  • RET Fusion-Positive Non-Small Cell Lung Cancer (NSCLC): Retevmo is approved for the treatment of adults with metastatic RET fusion-positive NSCLC.
  • RET-Mutant Medullary Thyroid Cancer (MTC): It is also approved for the treatment of adults and pediatric patients 12 years of age and older with advanced or metastatic RET-mutant MTC who require systemic therapy.
  • RET Fusion-Positive Thyroid Cancer: Retevmo is indicated for the treatment of adults and pediatric patients 12 years of age and older with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and have progressed following prior treatment.

How should this medicine be used?

Retevmo (selpercatinib) is a prescription medication, and its usage should be strictly in accordance with the guidance provided by the prescribing healthcare professional. The following general information provides an overview of how Retevmo is typically used, but individual circumstances may vary, so it’s important to follow the specific instructions given by your healthcare provider:

  • Dosage: The recommended dosage of Retevmo may depend on the type of cancer being treated (e.g., RET fusion-positive non-small cell lung cancer, RET-mutant medullary thyroid cancer, or RET fusion-positive thyroid cancer) and individual patient factors. The healthcare provider will determine the appropriate dosage for each patient.
  • Administration: Retevmo is usually taken orally (by mouth). The capsules should be swallowed whole with a glass of water. It’s essential not to crush or chew the capsules.
  • Timing: Retevmo can be taken with or without food. The healthcare provider will provide specific instructions on the timing of the medication.
  • Missed Dose: If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule should be resumed. It’s important not to take a double dose to make up for a missed one.
  • Follow-Up: Regular follow-up appointments with the healthcare provider are essential to monitor the response to treatment, manage any potential side effects, and adjust the treatment plan as needed.
  • Precautions: Before starting Retevmo, it’s important to inform the healthcare provider about any other medications, supplements, or health conditions. Certain medications or conditions may interact with Retevmo or affect its effectiveness.
  • Side Effects: Be aware of potential side effects and report any unusual or severe symptoms to the healthcare provider promptly.

Always consult with the prescribing healthcare professional or pharmacist if you have any questions or concerns about the proper use of Retevmo. They can provide personalized guidance based on your medical history and the specific details of your treatment plan.

Other uses for this medicine

Retevmo is specifically designed for the treatment of cancers associated with RET alterations. As of last update, there might be ongoing research and clinical trials exploring additional uses for Retevmo, but its primary indications are in the treatment of RET fusion-positive NSCLC and RET-mutant MTC.

What special precautions should I follow?

Special precautions and considerations should be taken into account when using Retevmo. It’s crucial to follow the guidance of your healthcare provider and inform them about your medical history and any other medications or supplements you are taking. Here are some general precautions associated with Retevmo:

  • Liver Function: Retevmo may affect liver function. Regular monitoring of liver function tests is typically recommended during treatment. Inform your healthcare provider if you have a history of liver problems.
  • High Blood Pressure: Retevmo may cause an increase in blood pressure. Blood pressure should be monitored regularly during treatment. If necessary, antihypertensive medications may be prescribed.
  • Bleeding Risk: There may be an increased risk of bleeding associated with Retevmo. Inform your healthcare provider if you have a history of bleeding disorders or are taking anticoagulant medications.
  • Thyroid Function: Retevmo may impact thyroid function. Thyroid function tests may be monitored, and thyroid hormone replacement may be necessary if thyroid function is affected.
  • Interstitial Lung Disease (ILD) or Pneumonitis: Retevmo may cause ILD or pneumonitis, which can be serious. Inform your healthcare provider if you experience new or worsening respiratory symptoms.
  • Pregnancy and Breastfeeding: Pregnant individuals or those planning to become pregnant should discuss the potential risks and benefits of Retevmo with their healthcare provider. It is also not known whether Retevmo passes into breast milk, so breastfeeding should be discussed with the healthcare provider.
  • Drug Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as supplements, that you are taking. Some drugs may interact with Retevmo.
  • Allergic Reactions: Seek medical attention if you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to remember that this information is not exhaustive, and individual patient circumstances may vary. Always follow the specific guidance provided by your healthcare provider and promptly report any concerning symptoms or side effects. Regular communication with your healthcare team is essential for the safe and effective use of Retevmo.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Retevmo. However, it’s crucial to follow any dietary advice provided by your healthcare provider. Always inform your healthcare team about any dietary supplements or herbal products you may be taking.

What should I do if I forget a dose?

If you forget to take a dose of Retevmo, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Retevmo (selpercatinib) may cause side effects, and it’s important for individuals to be aware of these potential adverse reactions. Keep in mind that not everyone will experience these side effects, and their severity can vary. Common side effects may include:

  • Hypertension (High Blood Pressure): Retevmo can lead to an increase in blood pressure. Regular monitoring of blood pressure is usually recommended during treatment.
  • Increased Liver Enzymes: Some individuals may experience elevated liver enzymes, which can be detected through liver function tests.
  • Increased Creatinine Levels: Retevmo may lead to an increase in creatinine levels, indicating potential kidney effects.
  • Fatigue: Feeling tired or fatigued is a common side effect of Retevmo.
  • Constipation: Some people may experience constipation during treatment.
  • Muscle and Joint Pain: Pain in the muscles and joints can occur.
  • Diarrhea: Diarrhea is a common gastrointestinal side effect associated with Retevmo.
  • Edema (Swelling): Swelling, particularly in the hands, feet, or face, may occur.
  • Shortness of Breath: Some individuals may experience difficulty breathing or shortness of breath.
  • Headache: Headaches can be a side effect of Retevmo.
  • Rash: Skin rash or itching may occur.
  • Nausea: Feeling nauseous or experiencing vomiting can be side effects.
  • Abdominal Pain: Pain in the abdominal area may occur.

It’s important to note that these side effects are not exhaustive, and other side effects may occur. Additionally, some side effects may be more severe or less common. If you experience any unusual or severe symptoms while taking Retevmo, it’s crucial to contact your healthcare provider promptly.

Patients are advised to report any side effects to their healthcare team, as they can provide guidance on managing symptoms and may adjust the treatment plan if necessary. In some cases, the benefits of the medication in treating cancer may outweigh the potential risks associated with side effects. Always follow the prescribed dosage and guidelines provided by your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal of Retevmo:

  • Storage:
    • Store Retevmo capsules at room temperature between 20°C to 25°C (68°F to 77°F).
    • Keep the medication in its original container, away from light and moisture.
    • Do not store Retevmo in the bathroom.
  • Disposal:
    • Dispose of unused or expired medication properly. Follow local regulations or guidelines for medication disposal.
    • Do not flush Retevmo down the toilet or throw it into the trash. Check with your pharmacist or local waste disposal facility for guidance on safe disposal.

In case of emergency/overdose

In case of an overdose or emergency, contact your local poison control center or emergency room immediately. Symptoms of overdose may include an increase in the severity of known side effects, and medical attention is essential.

What other information should I know?

  • Regular Follow-Up: Attend regular follow-up appointments with your healthcare provider to monitor the progress of your treatment, adjust the dosage if needed, and address any concerns.
  • Blood Tests: Expect regular blood tests to monitor liver function, blood pressure, and other relevant parameters.
  • Pregnancy and Contraception: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Use effective contraception during treatment and discuss family planning with your healthcare team.
  • Informing Healthcare Providers: Ensure that all healthcare providers (doctors, dentists, and others) are aware that you are taking Retevmo, as it may interact with other medications.
  • Allergies: Inform your healthcare provider about any known allergies or hypersensitivities to medications.
  • Adverse Reactions: Report any unexpected or severe reactions, side effects, or changes in your health to your healthcare provider promptly.
  • Diet and Medication Interactions: Discuss any dietary supplements, herbal products, or changes in diet with your healthcare provider, as they may interact with Retevmo.
  • Clinical Trials: Your healthcare provider may discuss the option of participating in clinical trials that may be investigating new treatments or combinations of treatments.
  • Insurance Coverage: Check with your insurance provider to understand the coverage and any potential financial assistance programs for Retevmo.

Always follow the instructions provided by your healthcare provider and the medication’s packaging. If you have any questions or concerns, don’t hesitate to consult your healthcare team for guidance.

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