PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

REGEN-COV (Generic Casirivimab and Imdevimab Injection)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!


If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.


Casirivimab and imdevimab injection is currently being studied for the treatment and prevention of coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus.

Clinical trial information is available at this time to support the use of casirivimab and imdevimab injection for the treatment of COVID-19. More information is needed to know how well the combination of casirivimab and imdevimab works for the treatment and prevention of COVID-19 and the possible adverse events from it.

Casirivimab and imdevimab injection has not undergone the standard review to be approved by the FDA for use. However, the FDA has approved an Emergency Use Authorization (EUA) to allow certain non-hospitalized adults and children 12 years of age and older to receive casirivimab and imdevimab injection.

Talk to your doctor about the risks and benefits of receiving this medication.

Why is this medication prescribed?

Casirivimab and imdevimab injection is used in certain non-hospitalized adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) and who have certain medical conditions that make them at higher risk for developing severe COVID-19 symptoms, including hospitalization or death:

  • To treat mild to moderate symptoms of COVID-19.
  • To prevent COVID-19 in those who are not fully vaccinated against COVID-19 or who are vaccinated, but have a weakened immune system, or are taking a medication that affects the immune system and who have had close contact or are at high risk of close contact to someone who is infected with the SARS-CoV-2 virus (for example, nursing homes, prisons).

Casirivimab and imdevimab are in a class of medications called monoclonal antibodies. They work by blocking the action of a certain natural substance in the body in order to stop the spread of the virus.

How should this medicine be used?

Casirivimab and imdevimab injection comes as a solution (liquid) to be mixed with liquid and infused (injected slowly) into a vein for 20 to 50 minutes or longer by a doctor or nurse. It also may be given subcutaneously (under the skin) as multiple separate injections in your abdomen, upper thighs, or the back of your upper arms around the same time.

For the treatment of COVID-19, it is given as a one-time dose injected into a vein as soon as possible after a positive test for COVID-19 and within 10 days after the start of COVID-19 infection symptoms such as a fever, cough, or shortness of breath. If your doctor decides that you are not able to receive casirivimab and imdevimab injection by infusion into a vein, it may be given subcutaneously (under the skin) to avoid a delay in treatment of COVID-19.

For the prevention of COVID-19 after exposure to someone who is infected with the SARS-CoV-2 virus, you will receive an initial dose, as either as subcutaneous injections or as an infusion into a vein as soon as possible after exposure. Your doctor will let you know if you need to receive additional monthly doses for ongoing protection.

Casirivimab and imdevimab may cause serious reactions during and after the infusion or injection of the medication. A doctor or nurse will monitor you carefully while you are receiving the medication and for at least 1 hour after you receive it. Tell your doctor or nurse immediately if you experience any of the following symptoms during or after the infusion: fever, chills, nausea, headache, changes in your heartbeat, chest pain, weakness or tiredness, confusion, trouble breathing or shortness of breath, wheezing, throat irritation, rash, hives, itching, muscle pain or aches, sweating, dizziness especially when standing up, or swelling of the face, throat, tongue, lips, or eyes. Your doctor may need to slow down your infusion or stop your treatment if you experience these side effects.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving casirivimab and imdevimab injection,

  • Tell your doctor and pharmacist if you are allergic to casirivimab, imdevimab, any other medications, or any of the ingredients in casirivimab and imdevimab injection. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: immunosuppressive medications such as cyclosporine (Gengraf, Neoral, Sandimmune), prednisone, and tacrolimus (Astagraf, Envarsus, Prograf). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • Tell your doctor if you have received a COVID-19 vaccine or have or have ever had any medical conditions.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving casirivimab and imdevimab, call your doctor.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Casirivimab and imdevimab may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • Pain, bleeding, bruising of the skin, soreness, swelling, or infection at injection site

Some side effects can be serious. If you experience any of these symptoms or those in the HOW section, call your doctor immediately or get emergency medical treatment.

  • Fever
  • Difficulty breathing
  • Changes in heart rate
  • Tiredness or weakness
  • Confusion

Casirivimab and imdevimab may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

What other information should I know?

Keep all appointments with your doctor.

Ask your pharmacist any questions you have about casirivimab and imdevimab injection.

You should continue to isolate as directed by your doctor and follow public health practices such as wearing a mask, social distancing, and frequent hand washing.

Treatment with casirivimab and imdevimab injection is not a substitute for receiving a COVID-19 vaccine. Talk to your healthcare provider about receiving a vaccine if you have not already been vaccinated to prevent COVID-19.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

Copyright © 2023