Why is this medication prescribed?

Recarbrio is a combination antibiotic medication that contains three active ingredients: imipenem, cilastatin, and relebactam. It is prescribed to treat complicated urinary tract infections (cUTI), including pyelonephritis, and complicated intra-abdominal infections (cIAI) in adults.

The three components of Recarbrio work together to combat bacterial infections. Imipenem is a carbapenem antibiotic, cilastatin prevents the breakdown of imipenem in the kidneys, and relebactam is a beta-lactamase inhibitor that helps protect imipenem from being degraded by certain enzymes produced by bacteria, extending its effectiveness.

How should this medicine be used?

Recarbrio is an antibiotic medication that is typically administered intravenously (IV) by a healthcare professional. The specific dosage and duration of treatment can vary based on factors such as the type and severity of the infection, the patient’s age and weight, renal function, and other individual considerations. It’s important to follow the healthcare provider’s instructions carefully. Here are some general guidelines:

• Administration by Healthcare Professional: Recarbrio is usually given by a healthcare professional in a hospital setting or another healthcare facility. The medication is administered through a vein (intravenously) over a specific period. The healthcare provider will determine the appropriate infusion rate.
• Dosage and Schedule: The dosage of Recarbrio will be determined by the healthcare provider based on the specific infection being treated and individual patient factors. The frequency of administration (how often the medication is given) and the duration of treatment will be specified by the healthcare provider.
• Complete the Full Course: It’s important to complete the entire course of treatment, even if symptoms improve before the medication is finished. Stopping the medication prematurely may lead to incomplete eradication of the infection and the potential for the development of antibiotic-resistant bacteria.
• Monitoring and Adjustments: The healthcare provider will monitor the patient’s response to treatment and may make adjustments to the dosage or treatment plan if necessary. Regular monitoring of laboratory parameters, including kidney function, may be performed during the course of treatment.
• Follow-up: After completing the course of Recarbrio, the healthcare provider may conduct follow-up assessments to ensure the infection has been successfully treated and to monitor for any potential side effects.

Always consult with your healthcare provider for specific instructions tailored to your individual health condition and needs. Do not self-prescribe or adjust the dosage without guidance from a healthcare professional, as improper use of antibiotics can contribute to antibiotic resistance and other health risks.

Other uses for this medicine

Recarbrio is primarily indicated for the treatment of complicated urinary tract infections (cUTI), including pyelonephritis, and complicated intra-abdominal infections (cIAI) in adults. It is specifically designed to address infections caused by susceptible Gram-negative microorganisms. The combination of imipenem, cilastatin, and relebactam in Recarbrio provides a broad spectrum of activity against bacteria.

What special precautions should I follow?

As for special precautions, it’s essential to consider the following:

• Allergies: Inform your healthcare provider of any known allergies, especially if you have had a hypersensitivity reaction to beta-lactam antibiotics (such as penicillins or cephalosporins) or any other component of Recarbrio.
• Renal Function: Recarbrio is eliminated primarily through the kidneys. Therefore, it is important to adjust the dosage in patients with impaired renal function. Your healthcare provider will assess your kidney function and determine the appropriate dosage based on your renal status.
• Seizures: Individuals with a history of seizures or other central nervous system disorders should use Recarbrio with caution. Seizures have been reported with the use of beta-lactam antibiotics, including imipenem.
• Clostridium difficile Infection: The use of antibiotics, including Recarbrio, may lead to overgrowth of Clostridium difficile, a bacterium that can cause colitis. Inform your healthcare provider if you experience persistent diarrhea during or after treatment.
• Superinfection: Prolonged use of Recarbrio may result in the overgrowth of non-susceptible bacteria or fungi. If a superinfection occurs, appropriate measures should be taken.
• Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity reactions (such as anaphylaxis) have been reported with beta-lactam antibiotics. If signs of hypersensitivity occur, discontinue the medication and seek medical attention.
• Use in Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The risks and benefits of using Recarbrio during pregnancy and breastfeeding should be discussed.
• Drug Interactions: Inform your healthcare provider about all medications, vitamins, and supplements you are currently taking, as certain drugs may interact with Recarbrio.

It’s crucial to follow your healthcare provider’s instructions and communicate any concerns or side effects promptly. Do not self-prescribe or adjust the dosage without consulting your healthcare professional. If you have specific health concerns or conditions, your healthcare provider can provide personalized advice based on your individual circumstances.

What special dietary instructions should I follow?

There are typically no specific dietary restrictions associated with Recarbrio. However, it’s essential to maintain a well-balanced diet and stay hydrated, especially if you are being treated for an infection.

What should I do if I forget a dose?

If you miss a dose of Recarbrio, it’s important to contact your healthcare provider for guidance. The timing of doses is critical for the effectiveness of the medication. Do not double up on doses to make up for a missed one unless directed by your healthcare provider. They will provide specific instructions on how to proceed based on the circumstances of the missed dose. It’s crucial to follow their guidance to ensure the appropriate and safe use of the medication.

What side effects can this medication cause?

Recarbrio, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed. Common and serious side effects associated with Recarbrio include:

Common Side Effects:

• Diarrhea: This is a common side effect of many antibiotics, including Recarbrio. It can range from mild to severe.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting during or after treatment.
• Headache: Headaches are a possible side effect of Recarbrio.
• Increased Liver Enzymes: There may be an increase in liver enzyme levels, which is typically monitored through blood tests.

Serious Side Effects:

• Allergic Reactions: Serious allergic reactions, including anaphylaxis, can occur. Seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, or severe skin reactions.
• Seizures: Beta-lactam antibiotics, including imipenem (one of the components of Recarbrio), have been associated with seizures.
• Clostridium difficile Infection: Prolonged use of antibiotics, including Recarbrio, may result in overgrowth of the bacterium Clostridium difficile, leading to colitis.
• Superinfection: Use of Recarbrio can lead to the overgrowth of non-susceptible bacteria or fungi.
• Renal Impairment: Kidney problems, including acute kidney injury, have been reported with the use of Recarbrio.

It’s crucial to report any unusual or severe side effects to your healthcare provider promptly. If you experience signs of a severe allergic reaction or a medical emergency, seek immediate medical attention.

This is not an exhaustive list of side effects, and individual responses to medications can vary. Your healthcare provider can provide more detailed information about the potential side effects of Recarbrio and help assess the risks and benefits of the medication based on your specific health condition.

What should I know about storage and disposal of this medication?

Storage and Disposal of Recarbrio:

• Storage:
  • Recarbrio is typically stored by healthcare providers in a healthcare setting, such as a hospital or clinic. It is usually stored in a refrigerator.
  • Follow the storage instructions provided by the healthcare facility or pharmacist.
• Disposal:
  • Disposal of unused or expired medications, including Recarbrio, should be done in accordance with local regulations and guidelines.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Check with your pharmacist or local waste disposal facility for proper disposal instructions.

In case of emergency/overdose

In case of an emergency or suspected overdose, contact your local emergency services or go to the nearest emergency room immediately. Symptoms of an overdose may include severe nausea, vomiting, seizures, or other serious reactions. It’s important to seek prompt medical attention if an overdose is suspected.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take Recarbrio exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider.
• Regular Monitoring: Your healthcare provider may conduct regular monitoring, including blood tests, to check for any potential side effects or changes in your health during the course of treatment.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care about the use of Recarbrio, including dentists and specialists. This information is important for a comprehensive understanding of your medication history.
• Avoid Alcohol: It’s generally advisable to avoid alcohol while taking antibiotics, including Recarbrio. Alcohol may interact with the medication and potentially increase the risk of side effects.
• Complete the Course: Complete the entire course of treatment, even if symptoms improve before the medication is finished. Stopping the medication prematurely may lead to incomplete eradication of the infection.
• Inform About Pregnancy/Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The risks and benefits of using Recarbrio during pregnancy and breastfeeding should be considered.

Always consult your healthcare provider or pharmacist if you have specific questions or concerns about Recarbrio or any medication. They can provide personalized information based on your health status and medical history.