Why is this medication prescribed?

Rayaldee is a prescription medication used to treat secondary hyperparathyroidism (SHPT) in adults with stage 3 or 4 chronic kidney disease (CKD) and serum total 25-hydroxyvitamin D levels less than 30 ng/mL. SHPT is a condition where the parathyroid glands produce too much parathyroid hormone (PTH) due to low levels of vitamin D. Rayaldee helps to raise and maintain vitamin D levels in the body, which can help regulate PTH levels.

How should this medicine be used?

It’s important to note that Rayaldee should be used under the supervision and guidance of a healthcare professional, and the dosage may vary depending on the individual’s specific condition. Here are some general guidelines on how Rayaldee may be used:

• Dosage: The typical starting dose of Rayaldee is 30 micrograms (mcg) once daily. The dosage may be adjusted by a healthcare provider based on individual patient needs.
• Administration: Rayaldee is usually taken by mouth with food. It’s important to take it consistently with a meal that contains some fat.
• Monitoring: Patients taking Rayaldee may have their vitamin D levels and other laboratory parameters monitored regularly by their healthcare provider to ensure that the medication is effective and well-tolerated.
• Compliance: It’s crucial for patients to follow their healthcare provider’s instructions regarding the use of Rayaldee and to take the medication as prescribed.
• Other Medications: Patients should inform their healthcare provider about all the medications they are taking, including over-the-counter drugs and supplements, as they may interact with Rayaldee.

As with any prescription medication, it’s essential for individuals to consult with their healthcare provider for personalized advice and to discuss any potential side effects or concerns. Only a qualified healthcare professional can determine the appropriate dosage and usage based on an individual’s specific health condition.

Other uses for this medicine

Rayaldee (calcifediol) is primarily indicated for the treatment of secondary hyperparathyroidism (SHPT) in adults with stage 3 or 4 chronic kidney disease (CKD) and serum total 25-hydroxyvitamin D levels less than 30 ng/mL. It’s important to note that the information provided here is based on the approved indications up to that date, and there may have been updates or changes since then.

What special precautions should I follow?

Regarding special precautions for Rayaldee, it’s crucial to follow the advice and guidelines provided by your healthcare provider. Here are some general precautions and considerations:

• Medical History: Before starting Rayaldee, inform your healthcare provider about your complete medical history, including any allergies, existing medical conditions, and current medications.
• Pregnancy and Breastfeeding: The safety of Rayaldee during pregnancy and breastfeeding is not well established. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as they will weigh the potential risks and benefits.
• Kidney Function: Since Rayaldee is used in individuals with chronic kidney disease, your healthcare provider will monitor your kidney function regularly. Adjustments to the dosage may be necessary based on kidney function.
• Drug Interactions: Inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking, as Rayaldee may interact with certain medications.
• Hypercalcemia: Rayaldee can increase calcium levels in the blood. Your healthcare provider will monitor your calcium levels regularly. If you experience symptoms of high calcium (such as nausea, vomiting, constipation, weakness), contact your healthcare provider.
• Gastrointestinal Issues: Rayaldee should be taken with food that contains some fat to enhance absorption. If you have gastrointestinal issues or malabsorption problems, discuss this with your healthcare provider.

Always follow your healthcare provider’s instructions and attend regular check-ups to monitor your response to Rayaldee. If you have specific concerns or questions about your treatment, don’t hesitate to discuss them with your healthcare team. It’s important to consulting with a healthcare professional for the most recent and personalized information is crucial.

What special dietary instructions should I follow?

• Food Intake: Rayaldee is usually taken with a meal that contains some fat. Follow your healthcare provider’s advice on dietary considerations while taking Rayaldee.
• Calcium Intake: Discuss with your healthcare provider the appropriate level of dietary calcium intake, as excessive calcium intake from food or supplements may contribute to hypercalcemia.

What should I do if I forget a dose?

If you forget to take a dose of Rayaldee, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure about what to do, contact your healthcare provider for guidance.

What side effects can this medication cause?

Rayaldee (calcifediol) may cause side effects, and it’s essential to be aware of potential reactions. Remember that individual responses can vary, and not everyone will experience the same side effects. If you are prescribed Rayaldee, your healthcare provider will discuss the potential risks and benefits with you. Common side effects of Rayaldee include:

• Headache: Some individuals may experience headaches as a side effect of Rayaldee.
• Dizziness: Rayaldee may cause dizziness in some people. It’s advisable to be cautious when engaging in activities that require alertness until you know how the medication affects you.
• Nausea: Nausea is another potential side effect of Rayaldee.
• Vomiting: Some individuals may experience vomiting while taking Rayaldee.
• Constipation: Constipation is a possible side effect. Maintaining adequate fluid intake and a fiber-rich diet may help alleviate this symptom.
• Hypercalcemia: Rayaldee can increase calcium levels in the blood, leading to hypercalcemia. Symptoms of hypercalcemia may include nausea, vomiting, constipation, weakness, and confusion. If you experience these symptoms, contact your healthcare provider promptly.
• Urinary Tract Infections (UTIs): UTIs have been reported as a side effect of Rayaldee.
• Respiratory Tract Infections: In some cases, individuals taking Rayaldee may experience respiratory tract infections.

It’s crucial to report any unusual or severe side effects to your healthcare provider promptly. Additionally, inform your healthcare provider about all medications, supplements, and over-the-counter drugs you are taking, as they may interact with Rayaldee.

This is not an exhaustive list of potential side effects, and there may be other reactions not mentioned here. If you have concerns about the side effects of Rayaldee or if you experience any unexpected symptoms, contact your healthcare provider for guidance. They can provide personalized advice based on your health history and current medications.

What should I know about storage and disposal of this medication?

Here are some general guidelines for Rayaldee:

Storage:

• Store as Directed: Keep Rayaldee stored according to the instructions provided by your healthcare provider or on the prescription label. Typically, it should be stored at room temperature away from light and moisture.
• Keep Out of Reach of Children: Store medications in a place that is inaccessible to children and pets.
• Avoid Extreme Conditions: Avoid storing Rayaldee in extreme temperatures (too hot or too cold) or in the bathroom, where moisture levels can be high.

Disposal:

• Follow Guidelines: Dispose of Rayaldee as instructed by your healthcare provider or pharmacist. Do not flush medications down the toilet unless specifically instructed to do so.
• Community Disposal Programs: Check if there are community programs or take-back events for medication disposal in your area. Many communities have designated locations for safe medication disposal.
• Ask Your Pharmacist: If you are unsure about how to dispose of Rayaldee or any other medications, ask your pharmacist for guidance.

In case of emergency/overdose

In case of emergency or overdose, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention immediately. Be prepared to provide information about the medication, the amount taken, and the time of ingestion.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Always take Rayaldee exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your healthcare provider.
• Regular Check-ups: Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness of the treatment and address any concerns or side effects.
• Inform Healthcare Provider: Keep your healthcare provider informed about all medications, supplements, and over-the-counter drugs you are taking to avoid potential interactions.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Rayaldee with your healthcare provider.
• Consultation with Healthcare Provider: If you have any questions or concerns about Rayaldee or your treatment plan, consult with your healthcare provider for guidance.

Always follow the specific instructions provided by your healthcare provider or pharmacist. This information is not exhaustive, and your healthcare team can provide personalized advice based on your individual health situation.