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Prudoxin Cream (Generic Doxepin Topical)

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Why is this medication prescribed?

Prudoxin (doxepin) is an antidepressant medication that belongs to the class of tricyclic antidepressants (TCAs). Prudoxin Cream, or any doxepin cream, is sometimes prescribed for the treatment of certain skin conditions, such as pruritus (itching) associated with various dermatological conditions. The cream may have anti-itching properties and can be applied topically to relieve itching.

How should this medicine be used?

Here is a general guideline on how Prudoxin Cream might be used:

  • Clean the affected area: Wash and dry the affected skin area before applying the cream.
  • Apply a thin layer: Use a small amount of Prudoxin Cream to cover the affected area with a thin layer. Rub it in gently.
  • Frequency of application: The frequency of application may vary based on the specific instructions provided by the prescribing healthcare professional. Follow the recommended dosage and application schedule.
  • Avoid contact with eyes, nose, and mouth: Be careful to avoid getting the cream in your eyes, nose, or mouth. If accidental contact occurs, rinse the affected area with water.
  • Consult your healthcare provider: If you have any questions or concerns about the use of Prudoxin Cream, consult your healthcare provider. They can provide specific instructions based on your medical condition and needs.

It is crucial to use the medication exactly as prescribed by your healthcare provider and not to exceed the recommended dosage. Additionally, inform your healthcare provider about any other medications you are taking to avoid potential interactions.

Keep in mind that the information provided here is based on knowledge, and there may have been developments or changes since then. Always consult with a healthcare professional or pharmacist for the most up-to-date and personalized information.

Other uses for this medicine

Prudoxin Cream, which contains doxepin, is primarily used for the treatment of pruritus (itching) associated with certain skin conditions. However, the use of medications can evolve, and new indications may emerge. It’s crucial to consult with a healthcare professional or refer to the latest medical resources for the most current information on the uses of Prudoxin Cream.

What special precautions should I follow?

In terms of special precautions for Prudoxin Cream, it’s important to consider the following:

  • Avoid sensitive areas: Be cautious when applying Prudoxin Cream near the eyes, nose, mouth, or other sensitive areas. Avoid contact with mucous membranes.
  • Allergic reactions: If you are allergic to doxepin or any other ingredients in the cream, inform your healthcare provider. Allergic reactions can include itching, swelling, severe dizziness, or difficulty breathing.
  • Medical history: Provide your healthcare provider with a comprehensive medical history, especially if you have a history of certain medical conditions such as glaucoma, urinary retention, or other conditions that may be affected by the use of tricyclic antidepressants.
  • Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Prudoxin Cream with your healthcare provider. It’s important to weigh the potential risks to the fetus or nursing infant.
  • Interactions with other medications: Inform your healthcare provider about all the medications you are currently taking, including prescription and over-the-counter drugs, as well as any herbal supplements. Drug interactions can occur, and your healthcare provider will need this information to ensure your safety.
  • Avoid excessive sunlight: Doxepin can increase sensitivity to sunlight. Limit sun exposure, wear protective clothing, and use sunscreen when outdoors.
  • Drowsiness and impairment: Prudoxin Cream, like other tricyclic antidepressants, may cause drowsiness or impair your ability to perform certain tasks. Avoid activities that require alertness until you know how the medication affects you.
  • Regular follow-up with healthcare provider: Attend regular follow-up appointments with your healthcare provider to monitor your response to the medication and address any concerns or side effects.

These precautions are general guidelines, and your specific situation may warrant additional considerations. Always follow your healthcare provider’s instructions and consult with them if you have any questions or concerns about the use of Prudoxin Cream.

What special dietary instructions should I follow?

As of last update, there were no specific dietary restrictions associated with Prudoxin Cream. However, it’s essential to maintain a balanced and healthy diet. If you have concerns about potential interactions with specific foods or dietary supplements, consult your healthcare provider.

What should I do if I forget a dose?

Since Prudoxin Cream is applied topically, the concept of forgetting a dose may not be applicable in the same way it is for oral medications. However, if you miss an application, follow these general guidelines:

  • Apply as Soon as Possible: If you remember shortly after missing a dose, apply the cream as soon as possible.
  • Skip If Close to Next Dose: If it’s almost time for your next scheduled application, skip the missed dose and continue with your regular dosing schedule.
  • Do Not Double Dose: Do not apply extra cream to make up for a missed dose. Double dosing may increase the risk of side effects.

What side effects can this medication cause?

Doxepin, the active ingredient in Prudoxin Cream, belongs to the class of tricyclic antidepressants. When applied topically, some individuals may experience side effects. Keep in mind that not everyone will experience these side effects, and the severity can vary from person to person. Common side effects of Prudoxin Cream may include:

  • Local Irritation: Mild redness, itching, or burning at the application site.
  • Dry Skin: Some individuals may experience dryness of the skin.
  • Skin Rash: In some cases, a rash may occur.
  • Hypersensitivity Reactions: Allergic reactions such as swelling, severe itching, or rash.

If you experience severe or persistent side effects, contact your healthcare provider promptly.

It’s important to note that systemic side effects (those affecting the entire body) are less likely with topical application compared to oral forms of doxepin. However, systemic absorption can still occur, especially if the cream is applied to a large area or if the skin barrier is compromised.

Seek immediate medical attention if you experience any signs of a serious allergic reaction, such as difficulty breathing, swelling of the face or throat, or severe dizziness.

This list of side effects is not exhaustive, and individuals may react differently to the medication. Always follow your healthcare provider’s instructions, report any unusual symptoms, and seek medical advice if you have concerns about side effects. Additionally, consult your healthcare provider for the most up-to-date and personalized information regarding the use of Prudoxin Cream.

What should I know about storage and disposal of this medication?

Here are general guidelines for storage and disposal:


  • Room Temperature: Store Prudoxin Cream at room temperature, away from excessive heat or cold.
  • Closed Container: Keep the cream in its original, tightly closed container to protect it from light and moisture.
  • Keep Out of Reach of Children: Store medications out of the reach of children and pets to prevent accidental ingestion.
  • Do Not Freeze: Avoid freezing the cream.
  • Follow Expiry Date: Check the expiration date on the packaging and do not use the cream beyond that date.


  • Follow Local Guidelines: Follow your local guidelines for medication disposal. Do not flush medications down the toilet unless specifically instructed to do so.
  • Medication Take-Back Programs: Check if there are medication take-back programs in your community or consult with your pharmacist for safe disposal options.
  • Discard Properly: If no take-back program is available, discard the medication in a way that prevents accidental ingestion by others. You can mix it with an undesirable substance (e.g., coffee grounds, kitty litter) in a sealed bag before throwing it in the trash.

In case of emergency/overdose

In the case of an emergency or suspected overdose, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention immediately. Overdose symptoms may include extreme drowsiness, confusion, seizures, irregular heartbeat, or fainting.

What other information should I know?

  • Follow Healthcare Provider’s Instructions: Always use Prudoxin Cream according to the instructions provided by your healthcare provider. Follow the recommended dosage and application frequency.
  • Inform Healthcare Provider: Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter drugs, and herbal supplements, to avoid potential interactions.
  • Regular Follow-up: Attend regular follow-up appointments with your healthcare provider to monitor your response to the medication and address any concerns or side effects.
  • Avoid Sun Exposure: Due to the potential for increased sensitivity to sunlight, limit sun exposure, wear protective clothing, and use sunscreen.
  • Report Side Effects: Report any unusual or severe side effects to your healthcare provider promptly.

These guidelines are general in nature, and it’s important to follow specific instructions provided by your healthcare provider and adhere to any additional recommendations on the medication packaging. If there have been updates or changes to the information since last update, consult the latest medical resources or your healthcare provider for the most current information.

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