WARNING

Chlorpromazine is an antipsychotic medication used to treat various mental health conditions, such as schizophrenia and bipolar disorder. While it can be effective in managing symptoms, there are potential risks and side effects associated with its use. It’s essential to note that the following information is a general overview, and individual responses may vary.

• Extrapyramidal Symptoms (EPS): Chlorpromazine can cause EPS, which include symptoms like tremors, muscle stiffness, and difficulty in voluntary movements. Tardive dyskinesia, a potentially irreversible movement disorder, may also occur with long-term use.
• Sedation and Drowsiness: Chlorpromazine can cause sedation and drowsiness, affecting an individual’s ability to concentrate or operate machinery. This may be particularly significant when starting the medication or adjusting the dosage.
• Orthostatic Hypotension: A sudden drop in blood pressure upon standing, known as orthostatic hypotension, can occur with chlorpromazine. This may lead to dizziness, lightheadedness, or fainting.
• Anticholinergic Effects: Chlorpromazine may cause anticholinergic side effects, including dry mouth, blurred vision, constipation, and urinary retention.
• Weight Gain: Some individuals may experience weight gain while taking chlorpromazine, which could contribute to other health issues over time.
• Metabolic Effects: There is an association between certain antipsychotic medications, including chlorpromazine, and metabolic effects such as elevated blood sugar levels, increased cholesterol, and weight gain. Regular monitoring of metabolic parameters is essential.
• Neuroleptic Malignant Syndrome (NMS): Although rare, NMS is a severe and potentially life-threatening reaction to antipsychotic medications like chlorpromazine. Symptoms may include hyperthermia, muscle rigidity, altered mental status, and autonomic dysfunction.
• Blood Disorders: Chlorpromazine may affect blood cells, potentially leading to conditions like agranulocytosis (a severe reduction in white blood cells) or other blood disorders.
• Increased Risk of Falls: Due to the sedative and orthostatic hypotensive effects, there is an increased risk of falls, especially in older adults.

It’s crucial for individuals taking chlorpromazine to have regular check-ups with their healthcare provider to monitor for potential side effects and adjust the treatment plan as needed. Always follow the prescribed dosage and inform your healthcare provider of any concerns or changes in your health status. This information is not exhaustive, and it’s essential to consult with a healthcare professional for personalized advice based on individual health conditions.

Why is this medication prescribed?

Chlorpromazine is prescribed primarily to treat various mental health conditions, particularly psychotic disorders. It belongs to a class of medications known as typical antipsychotics or first-generation antipsychotics. Here are some common reasons why chlorpromazine may be prescribed:

• Schizophrenia: Chlorpromazine is often used in the treatment of schizophrenia, a severe mental disorder characterized by distorted thinking, hallucinations, and a diminished ability to engage in daily activities.
• Bipolar Disorder: It may be prescribed to manage symptoms of bipolar disorder, especially during manic episodes.
• Severe Anxiety: In some cases, chlorpromazine may be used to alleviate severe anxiety or agitation.
• Severe Behavioral Disorders: It might be prescribed for individuals with severe behavioral disorders or aggression.
• Nausea and Vomiting: Chlorpromazine can also be used to control severe nausea and vomiting.
• Hiccups: In certain situations, chlorpromazine is prescribed to alleviate persistent hiccups.

How should this medicine be used?

It is crucial to follow the prescribed dosage and instructions provided by the healthcare professional. The dosing regimen may vary depending on the specific condition being treated, the individual’s response to the medication, and other factors. Here are some general guidelines:

• Dosage: The initial dosage is usually low and is gradually increased based on the patient’s response. It’s important not to adjust the dosage without consulting the healthcare provider.
• Administration: Chlorpromazine is typically taken orally, with or without food. The tablets or liquid form should be taken as directed.
• Consistency: It is important to take chlorpromazine regularly and consistently. Missing doses may reduce its effectiveness.
• Monitoring: Regular check-ups with a healthcare provider are necessary to monitor the individual’s response to the medication and assess for any potential side effects.
• Duration of Treatment: The duration of treatment varies depending on the condition being treated. It’s important not to stop taking chlorpromazine abruptly without consulting a healthcare professional, as this can lead to withdrawal symptoms.
• Special Instructions: Individuals should inform their healthcare provider about any other medications, supplements, or medical conditions they have, as chlorpromazine may interact with other drugs or exacerbate certain health issues.

It’s crucial for individuals taking chlorpromazine to communicate openly with their healthcare provider, report any side effects promptly, and attend regular follow-up appointments. This information provides a general overview, and specific instructions may vary based on the individual’s health status and the prescribing healthcare professional’s recommendations

Other uses for this medicine

While chlorpromazine is primarily prescribed for psychotic disorders, bipolar disorder, severe anxiety, and nausea/vomiting, it may also be used off-label for other conditions. Some of these off-label uses include:

• Agitation and Aggressive Behavior: Chlorpromazine may be used to manage severe agitation and aggressive behavior in various clinical settings.
• Delirium: In some cases, chlorpromazine may be considered for the treatment of delirium, a state of severe confusion and disorientation.
• Chronic Hiccups: Chlorpromazine has been used to alleviate persistent and severe hiccups that do not respond to other treatments.
• Intractable Pain: In certain situations, chlorpromazine may be used as an adjuvant for managing intractable pain, particularly when other treatments have not been successful.

What special precautions should I follow?

When taking chlorpromazine, individuals should follow specific precautions to ensure safe and effective use. Here are some important considerations:

• Medical History: Inform your healthcare provider of your complete medical history, especially if you have a history of liver or kidney problems, blood disorders, cardiovascular issues, seizures, or glaucoma.
• Allergies: Inform your healthcare provider about any allergies to medications or other substances.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of chlorpromazine with your healthcare provider. The medication may be used cautiously during pregnancy if the potential benefits outweigh the risks.
• Driving and Operating Machinery: Due to the potential for sedation and drowsiness, individuals taking chlorpromazine should exercise caution when driving or operating heavy machinery.
• Alcohol and Other Substances: Avoid or limit the consumption of alcohol while taking chlorpromazine. Additionally, inform your healthcare provider about any other medications, supplements, or recreational drugs you may be using, as they can interact with chlorpromazine.
• Regular Monitoring: Regular monitoring of blood pressure, heart rate, and other relevant parameters is essential during chlorpromazine treatment.
• Heat Exposure: Chlorpromazine may impair the body’s ability to regulate temperature. Therefore, individuals should avoid excessive heat exposure, such as hot baths or prolonged sun exposure.
• Blood Tests: Periodic blood tests may be necessary to monitor for potential side effects, such as changes in blood cell count or metabolic parameters.

It’s crucial to communicate openly with your healthcare provider, attend regular check-ups, and report any unusual or severe side effects promptly. These precautions can help ensure the safe and effective use of chlorpromazine for your specific health condition.

What special dietary instructions should I follow?

Special Dietary Instructions for Chlorpromazine:

• Grapefruit Juice: Avoid consuming grapefruit or grapefruit juice while taking chlorpromazine, as it can interfere with the metabolism of the medication.
• Dietary Fiber: A diet rich in fiber may help alleviate constipation, a common side effect of chlorpromazine. Ensure an adequate intake of fruits, vegetables, and whole grains.
• Hydration: Stay well-hydrated, as chlorpromazine can cause dry mouth. Drinking water or chewing sugarless gum can help manage this side effect.

What should I do if I forget a dose?

If you forget to take a dose of chlorpromazine, follow these general guidelines:

• Take it as Soon as Possible: If you remember shortly after the missed dose, take it as soon as you remember.
• Skip If It’s Almost Time for the Next Dose: If it’s almost time for your next scheduled dose, skip the missed one. Do not double the dose to make up for the missed one.
• Inform Your Healthcare Provider: If you consistently forget doses or have concerns about your medication schedule, inform your healthcare provider. They can provide guidance and may adjust your treatment plan if necessary.

What side effects can this medication cause?

Chlorpromazine, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Common side effects of chlorpromazine include:

• Sedation: Chlorpromazine can cause drowsiness and sedation, particularly when you first start taking it or when the dosage is increased.
• Orthostatic Hypotension: A sudden drop in blood pressure upon standing, leading to dizziness or fainting.
• Extrapyramidal Symptoms (EPS):
  • Tardive Dyskinesia: Involuntary, repetitive movements of the face and body that can be irreversible.
  • Parkinsonism: Symptoms similar to Parkinson’s disease, such as tremors, muscle stiffness, and difficulty with balance and coordination.
  • Akathisia: Restlessness and an inability to sit still.
• Anticholinergic Effects:
  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention
• Weight Gain: Some individuals may experience weight gain while taking chlorpromazine.
• Metabolic Effects: There is an association between chlorpromazine and metabolic effects, including elevated blood sugar levels, increased cholesterol, and weight gain.
• Neuroleptic Malignant Syndrome (NMS): A rare but serious condition characterized by fever, muscle rigidity, altered mental status, and autonomic dysfunction. NMS requires immediate medical attention.
• Blood Disorders: Chlorpromazine may affect blood cells, potentially leading to conditions like agranulocytosis (a severe reduction in white blood cells) or other blood disorders.
• Photosensitivity: Increased sensitivity to sunlight, making individuals more prone to sunburn.
• Endocrine Effects: Rarely, chlorpromazine may affect hormonal regulation, leading to conditions like galactorrhea (abnormal lactation) or menstrual irregularities.

It’s important to promptly report any unusual or severe side effects to your healthcare provider. Additionally, the prescribing healthcare professional may monitor your health through regular check-ups and blood tests to identify and address any potential adverse effects. This list is not exhaustive, and individuals may experience side effects not mentioned here. Always consult with your healthcare provider for personalized information based on your health status and medication history.

What should I know about storage and disposal of this medication?

Storage and Disposal of Chlorpromazine:

• Storage:
  • Keep chlorpromazine in its original packaging and at room temperature, away from moisture and heat.
  • Store the medication out of reach of children and pets.
  • Follow any specific storage instructions provided by your healthcare provider or pharmacist.
• Disposal:
  • Dispose of unused or expired chlorpromazine according to local regulations or guidelines.
  • Do not flush medications down the toilet unless instructed to do so. Instead, consult with your local pharmacy or healthcare provider on proper disposal methods.
  • Some communities have drug take-back programs or designated disposal sites for medications. Check with local authorities for options in your area.

In case of emergency/overdose

In case of an overdose or emergency, contact your local poison control center at 1-800-222-1222 or seek immediate medical attention. Symptoms of overdose may include severe drowsiness, fainting, irregular heartbeats, or uncontrollable movements.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take chlorpromazine exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting them.
• Regular Monitoring: Attend scheduled check-ups with your healthcare provider to monitor your response to chlorpromazine and assess for any potential side effects.
• Inform Healthcare Provider: Keep your healthcare provider informed about all medications, supplements, and over-the-counter drugs you are taking to avoid potential interactions.
• Avoid Alcohol: Limit or avoid alcohol consumption while taking chlorpromazine, as it can enhance the sedative effects of the medication.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of chlorpromazine with your healthcare provider.
• Driving and Operating Machinery: Be cautious when driving or operating heavy machinery, especially when you first start taking chlorpromazine, as it may cause drowsiness.
• Sun Exposure: Use sunscreen and protective clothing to minimize the risk of sunburn, as chlorpromazine can increase sensitivity to sunlight.
• Medical Alert Bracelet/ID: In certain cases, wearing a medical alert bracelet or carrying identification indicating the use of chlorpromazine may be advisable, especially if you have a medical condition that could require emergency medical attention.

Always consult with your healthcare provider or pharmacist for specific guidance based on your individual health status and the prescribed dosage of chlorpromazine. If you have any concerns or experience unusual symptoms, seek medical advice promptly.