WARNING

Promacta, also known as eltrombopag, is a medication used to treat conditions associated with low platelet counts, such as chronic immune thrombocytopenia (ITP) and severe aplastic anemia. While it can be effective in managing these conditions, like any medication, Promacta comes with potential risks and side effects. It’s important to note that individual responses to the medication can vary, and not everyone will experience these issues. Here are some of the potential risks associated with taking Promacta:

• Liver problems: Promacta can affect the liver, leading to an increased risk of liver abnormalities. Regular monitoring of liver function is usually recommended during treatment.
• Blood clotting: There is a potential risk of blood clot formation with Promacta. Patients with a history of blood clotting disorders or other risk factors may require close monitoring.
• Cataracts: Some patients may develop cataracts while taking Promacta. Regular eye examinations are recommended to detect and manage this potential side effect.
• Bone marrow changes: Promacta can stimulate the production of bone marrow cells. Monitoring bone marrow function is important to ensure it does not lead to excessive bone marrow activity.
• Fluid retention: Edema (fluid retention) has been reported in some individuals taking Promacta. Monitoring for signs of swelling or fluid accumulation is advisable.
• Increased risk of hematologic malignancies: Long-term use of Promacta may be associated with an increased risk of developing hematologic malignancies. The benefits of treatment should be weighed against this potential risk.

It’s crucial to discuss your medical history, including any pre-existing conditions or medications you may be taking, with your healthcare provider before starting Promacta. Additionally, regular check-ups and monitoring as recommended by your healthcare team are essential to detect and manage any potential side effects promptly. This information is not exhaustive, and individual responses to the medication may vary, so always consult with your healthcare provider for personalized advice and guidance.

Why is this medication prescribed?

Promacta (eltrombopag) is prescribed to treat certain medical conditions characterized by low platelet counts. Platelets are blood cells that play a crucial role in blood clotting. When platelet counts are too low, it can lead to increased bleeding and other complications. Promacta is primarily used for the following conditions:

• Chronic Immune Thrombocytopenia (ITP): ITP is a disorder in which the immune system mistakenly attacks and destroys platelets, leading to a low platelet count. Promacta is used to increase platelet production and reduce the risk of bleeding in individuals with chronic ITP who have not responded to other treatments.
• Severe Aplastic Anemia: Promacta may also be prescribed for individuals with severe aplastic anemia, a condition where the bone marrow fails to produce enough blood cells, including platelets.

How should this medicine be used?

The dosage and duration of Promacta treatment will be determined by the prescribing healthcare provider based on the specific condition, the severity of the disease, and the individual patient’s response. Here are some general guidelines on how Promacta is commonly used:

• Dosage: The recommended dosage of Promacta can vary depending on the patient’s condition. It is essential to follow the healthcare provider’s instructions regarding the prescribed dosage.
• Administration: Promacta is typically taken orally as a tablet, with or without food. The tablets should be swallowed whole and not crushed or split.
• Regular Monitoring: During treatment with Promacta, regular monitoring of platelet counts and other relevant blood parameters is important. This helps healthcare providers adjust the dosage as needed and monitor for any potential side effects.
• Adherence to Treatment Plan: It is crucial to take Promacta as prescribed by the healthcare provider. Missing doses or altering the dosage without medical guidance can affect the effectiveness of the treatment.
• Potential Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as some substances may interact with Promacta.
• Follow-up Appointments: Regular follow-up appointments with the healthcare provider are recommended to assess the progress of the treatment, monitor for side effects, and make any necessary adjustments to the treatment plan.

It’s important to note that the information provided here is a general overview, and specific instructions may vary based on individual circumstances. Always follow the guidance of your healthcare provider and consult them with any questions or concerns about your treatment with Promacta.

Other uses for this medicine

In addition to its primary uses in treating chronic immune thrombocytopenia (ITP) and severe aplastic anemia, Promacta (eltrombopag) is also prescribed in certain situations related to low platelet counts. These may include:

• Hepatitis C-Related Thrombocytopenia: Promacta may be used to increase platelet counts in patients with chronic hepatitis C infection who are undergoing treatment with interferon and ribavirin and have thrombocytopenia (low platelet counts) as a side effect.
• Thrombocytopenia in Pediatric Patients: Promacta is approved for the treatment of thrombocytopenia in pediatric patients aged 1 year and older with chronic ITP who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy.

What special precautions should I follow?

When using Promacta, certain precautions should be taken, and patients should be closely monitored. Here are some key considerations:

• Liver Function Monitoring: Regular monitoring of liver function is essential during treatment with Promacta, as the medication can affect the liver. Elevated liver enzymes may occur, and in some cases, serious liver problems have been reported.
• Risk of Blood Clots: Promacta can increase the risk of blood clot formation. Patients with a history of blood clotting disorders or risk factors for thromboembolism should be closely monitored, and the benefits of treatment should be weighed against the potential risks.
• Cataract Formation: Regular eye examinations are recommended during Promacta treatment, as cataracts have been reported in some patients.
• Bone Marrow Changes: Promacta can stimulate bone marrow activity. Monitoring of bone marrow function is advised to ensure that excessive bone marrow activity does not occur.
• Pediatric Use: When prescribed for pediatric patients, the healthcare provider should carefully consider the potential benefits and risks of treatment, taking into account the child’s age and overall health.
• Pregnancy and Breastfeeding: The safety of Promacta during pregnancy and breastfeeding is not well established. Pregnant or breastfeeding individuals should discuss the potential risks and benefits with their healthcare provider.
• Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions with Promacta.

As with any medication, it’s crucial to follow your healthcare provider’s instructions, attend regular check-ups, and report any side effects or concerns promptly. The information provided here is a general overview, and individual circumstances may vary, so consult with your healthcare provider for personalized advice.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with Promacta use. However, it’s essential to maintain a well-balanced and healthy diet as advised by your healthcare provider. Certain foods and beverages may interact with medications or impact liver function, so it’s advisable to discuss your diet with your healthcare provider.

What should I do if I forget a dose?

If you forget to take a dose of Promacta, follow these general guidelines:

• Take the missed dose as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• If you are unsure about what to do, contact your healthcare provider for guidance.

What side effects can this medication cause?

Promacta (eltrombopag) may cause various side effects, and individuals may experience them to varying degrees. It’s important to note that not everyone will experience these side effects, and some people may not experience any at all. If you are prescribed Promacta, your healthcare provider will closely monitor your response to the medication. Common side effects of Promacta include:

• Nausea: Feeling sick to your stomach.
• Headache: Pain or discomfort in the head.
• Fatigue: Feeling tired or weak.
• Diarrhea: Abnormally frequent bowel movements that may be watery.
• Upper Respiratory Tract Infection: Infections of the nose, throat, or chest.
• Increased Liver Enzymes: Elevated levels of liver enzymes may occur, so regular monitoring of liver function is essential.

Less common but potentially more serious side effects include:

• Blood Clots: Promacta may increase the risk of blood clot formation, which can be serious. Inform your healthcare provider if you have a history of blood clotting disorders.
• Serious Liver Problems: In rare cases, Promacta has been associated with serious liver problems. It’s important to promptly report any signs of liver issues, such as jaundice (yellowing of the skin or eyes) or dark urine.
• Cataracts: Some patients may develop cataracts during Promacta treatment. Regular eye examinations are recommended.
• Bone Marrow Changes: Promacta can stimulate bone marrow activity, and excessive bone marrow activity may occur in some cases.
• Allergic Reactions: Serious allergic reactions are rare but possible. Seek medical attention immediately if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s crucial to promptly report any unusual or severe side effects to your healthcare provider. Additionally, keep all scheduled appointments for monitoring your blood counts and overall health.

This list is not exhaustive, and individual responses to the medication may vary. Your healthcare provider will provide specific information tailored to your medical history and condition. Always consult with your healthcare provider for personalized advice and guidance regarding the potential side effects of Promacta.

What should I know about storage and disposal of this medication?

Storage and Disposal of Promacta:

• Storage:
  • Store Promacta at room temperature, away from excessive heat and moisture.
  • Keep the medication in its original packaging to protect it from light.
  • Do not freeze Promacta.
• Disposal:
  • Dispose of unused or expired Promacta in accordance with local regulations and guidelines.
  • Do not flush medications down the toilet or pour them into drains unless specifically instructed to do so.
  • Consult with your healthcare provider or pharmacist for proper disposal methods, such as using a medication take-back program.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek immediate medical attention. Symptoms of overdose may include nausea, vomiting, headache, increased liver enzymes, and potential complications related to excessive platelet production.

What other information should I know?

• Regular Monitoring: Follow your healthcare provider’s recommendations for regular monitoring of blood counts and liver function during Promacta treatment.
• Medical Alert Bracelet/ID: If advised by your healthcare provider, consider wearing a medical alert bracelet or carrying identification indicating that you are taking Promacta. This can be helpful in case of emergencies or if you are unable to communicate your medical history.
• Inform Healthcare Providers: Ensure that all healthcare providers involved in your care are aware that you are taking Promacta. This includes dentists, surgeons, and other specialists.
• Interactions with Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as some substances may interact with Promacta.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Promacta with your healthcare provider.
• Travel Considerations: If you plan to travel, ensure that you have an adequate supply of Promacta and any necessary documentation for transportation. Consult your healthcare provider for specific recommendations.
• Patient Assistance Programs: If you are having difficulty affording your medication, inquire about patient assistance programs that may be available to provide financial assistance.

Always follow your healthcare provider’s instructions and seek their guidance for any specific concerns or questions related to your individual situation. The information provided here is a general overview, and your healthcare provider will provide personalized advice based on your medical history and condition.