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Priftin (Generic Rifapentine)

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Why is this medication prescribed?

Priftin is a brand name for the medication rifapentine, which belongs to a class of drugs known as rifamycins. Rifapentine is primarily used in the treatment of tuberculosis (TB). It is often prescribed in combination with other anti-tuberculosis medications as part of a comprehensive treatment regimen.

How should this medicine be used?

Here are some key points regarding the use of Priftin:

  • Treatment of Tuberculosis (TB): Priftin is used to treat active pulmonary tuberculosis. It is typically used in combination with other TB medications, such as isoniazid.
  • Duration of Treatment: The duration of treatment with Priftin varies and is usually determined by a healthcare professional based on the specific circumstances of the patient. TB treatment often involves a combination of several drugs taken for an extended period to ensure complete eradication of the bacteria.
  • Dosage: The dosage of Priftin can vary, and it is important to follow the prescribed dose provided by the healthcare provider. The medication is often taken once or twice weekly, and the exact schedule will be determined by the healthcare professional.
  • Administration: Priftin is usually taken orally with food. It is important to take the medication consistently and complete the full course of treatment as prescribed.
  • Monitoring: During the course of treatment, healthcare providers may monitor patients for any side effects or potential interactions with other medications. Regular check-ups and laboratory tests may be recommended to ensure the effectiveness of the treatment.

It’s crucial to note that Priftin should be used only under the supervision and guidance of a healthcare professional. It is essential to inform your healthcare provider about any other medications, supplements, or medical conditions you have, as they can influence the choice of treatment and potential interactions.

As individual cases may vary, it is important to consult with a healthcare professional for personalized advice and information tailored to your specific situation.

Other uses for this medicine

Priftin (rifapentine) is primarily used in the treatment of tuberculosis (TB) and is not typically prescribed for other conditions. It belongs to the rifamycin class of antibiotics, which are particularly effective against mycobacteria, the type of bacteria that cause tuberculosis. As such, the primary use of Priftin is in the context of TB treatment.

What special precautions should I follow?

Special precautions should be taken when using Priftin, and it is important to follow the guidance provided by your healthcare provider. Here are some general precautions associated with Priftin use:

  • TB Treatment Plan: Priftin is usually prescribed as part of a comprehensive TB treatment plan, which may include other medications such as isoniazid. It’s crucial to follow the prescribed regimen exactly as directed by your healthcare provider.
  • Drug Interactions: Priftin may interact with other medications. Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking to ensure there are no potential interactions.
  • Liver Function Monitoring: Rifapentine, like other rifamycins, can affect liver function. Regular monitoring of liver function through blood tests may be required during the course of treatment. If you experience symptoms such as jaundice, dark urine, or persistent nausea, notify your healthcare provider promptly.
  • Allergies: Inform your healthcare provider of any known allergies to rifamycins or other medications.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Priftin with your healthcare provider. The medication may be used during pregnancy if the benefits outweigh the risks, but this decision should be made in consultation with a healthcare professional.
  • HIV Infection: If you have HIV or another immunocompromising condition, the management of TB may require additional considerations. Inform your healthcare provider about your HIV status and any other underlying health conditions.

Always take Priftin exactly as prescribed, and do not stop the medication without consulting your healthcare provider. It’s important to complete the full course of treatment to ensure the effective eradication of TB bacteria and reduce the risk of developing drug-resistant strains. If you have any concerns or experience side effects while taking Priftin, contact your healthcare provider promptly.

What special dietary instructions should I follow?

Special Dietary Instructions:

  • Food Intake: Priftin should be taken with food to enhance absorption. Taking it on an empty stomach may result in reduced absorption.
  • Avoid Alcohol: It’s generally advisable to limit or avoid alcohol while taking Priftin, as both the medication and alcohol can affect the liver. Consult your healthcare provider regarding alcohol consumption.

What should I do if I forget a dose?

  • Missed Dose: If you forget to take a dose of Priftin, take it as soon as you remember. If it’s almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule.
  • Double Dosing: Do not double the dose to make up for a missed one. Taking two doses close together may increase the risk of side effects without providing additional benefits.
  • Consult Your Healthcare Provider: If you have concerns about missed doses or if you frequently miss doses, contact your healthcare provider. They can provide guidance on how to manage missed doses and may adjust the treatment plan if necessary.

What side effects can this medication cause?

Priftin (rifapentine) can cause side effects, and it’s important to be aware of them while undergoing treatment. Not everyone will experience these side effects, and their severity can vary. If you notice any unusual or persistent symptoms, it’s crucial to inform your healthcare provider. Common side effects of Priftin include:

  • Discoloration of Body Fluids: Priftin can cause a harmless but noticeable discoloration of body fluids, including urine, saliva, sweat, and tears. This discoloration is usually orange or red and is not harmful.
  • Digestive System Issues: Some people may experience gastrointestinal side effects, such as nausea, vomiting, stomach upset, or changes in bowel habits.
  • Skin Reactions: Priftin may cause skin reactions, including rash or itching.
  • Flu-like Symptoms: Patients may experience flu-like symptoms, such as fever, chills, and muscle aches.
  • Hepatotoxicity: Rifapentine, like other rifamycins, can affect liver function. Signs of liver problems include jaundice (yellowing of the skin or eyes), dark urine, and persistent nausea. Regular monitoring of liver function through blood tests is typically conducted during treatment.
  • Hypersensitivity Reactions: In rare cases, individuals may experience allergic reactions, including severe skin reactions or difficulty breathing. Seek immediate medical attention if you develop signs of a severe allergic reaction.

It’s important to note that this is not an exhaustive list of side effects, and individual experiences may vary. Some side effects may be more serious, so it’s crucial to promptly report any unexpected or severe symptoms to your healthcare provider.

Additionally, Priftin may interact with other medications, potentially affecting their efficacy or causing adverse effects. Inform your healthcare provider about all the medications, supplements, and herbal products you are taking to minimize the risk of drug interactions.

Remember that the benefits of treating tuberculosis with Priftin generally outweigh the risks of potential side effects. Your healthcare provider will closely monitor your response to the medication and can adjust the treatment plan if needed. Always follow your healthcare provider’s guidance and attend regular check-ups to ensure the effectiveness of the treatment and manage any potential side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Priftin:

  • Store Priftin (rifapentine) at room temperature, away from excessive heat and moisture.
  • Keep the medication in its original packaging or container.
  • Do not store Priftin in the bathroom.
  • Keep Away from Children and Pets:
  • Store Priftin out of the reach of children and pets.
  • Accidental ingestion can be harmful.


  • Dispose of unused or expired Priftin properly.
  • Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
  • Check with your pharmacist or local waste disposal facility for guidance on proper disposal.

In case of emergency/overdose

In case of an overdose or if someone has ingested Priftin accidentally, seek emergency medical attention or contact a poison control center immediately.
Symptoms of overdose may include severe nausea, vomiting, and liver problems.

What other information should I know?

  • Regular Check-ups: Attend regular check-ups with your healthcare provider to monitor the progress of your treatment and address any concerns.
  • Complete the Full Course: Complete the full course of Priftin as prescribed by your healthcare provider, even if you start feeling better before the medication is finished.
  • Follow Instructions: Take Priftin exactly as directed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting them.
  • Inform Your Healthcare Provider: Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential drug interactions.
  • Disclose Medical History: Provide a comprehensive medical history to your healthcare provider, including any history of liver disease, allergies, or other relevant conditions.
  • Birth Control: If you are using hormonal contraceptives, discuss potential interactions with your healthcare provider, as rifapentine may reduce their effectiveness.
  • Discoloration of Body Fluids: Be aware that Priftin can cause a harmless discoloration of body fluids, such as urine, saliva, sweat, and tears.
  • Follow Dietary Instructions: Take Priftin with food to enhance absorption and follow any dietary instructions provided by your healthcare provider.
  • Allergic Reactions: Seek medical attention if you experience signs of a severe allergic reaction, such as difficulty breathing or a severe skin rash.

Always consult with your healthcare provider for personalized advice and information tailored to your specific situation. If you have any questions or concerns about Priftin, do not hesitate to reach out to your healthcare provider for guidance.

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