Why is this medication prescribed?

Prevalite is a brand name for cholestyramine, which is a medication used to lower high levels of cholesterol in the blood. Cholestyramine belongs to a class of drugs known as bile acid sequestrants. It works by binding to bile acids in the intestine, preventing them from being reabsorbed into the bloodstream. As a result, the body uses more cholesterol to produce new bile acids, leading to a reduction in overall cholesterol levels.

Prevalite is prescribed for the treatment of:

• Hypercholesterolemia: Elevated levels of low-density lipoprotein (LDL) cholesterol, often referred to as “bad” cholesterol.
• Pruritus associated with partial biliary obstruction: It may also be used to relieve itching caused by bile duct disorders.

How should this medicine be used?

The usual dosage and administration instructions for Prevalite can vary depending on the individual’s condition and the healthcare provider’s recommendations. Generally, Prevalite is taken orally in the form of a powder or granules, which should be mixed with water, fruit juice, or other beverages before ingestion. Here are some general guidelines for using Prevalite:

• Mix the prescribed dose with a sufficient amount of water, non-carbonated beverage, or a liquid of your choice.
• Stir well and drink the mixture immediately.
• It is important to take Prevalite as directed by your healthcare provider, usually one to six times per day, with meals or as recommended.
• It is crucial to follow a proper diet, exercise, and other lifestyle modifications as advised by your healthcare professional to achieve the best results in managing cholesterol levels.
• Prevalite may interfere with the absorption of certain medications, so it’s essential to take other medications at least 1 hour before or 4 to 6 hours after taking Prevalite.

Always consult with your healthcare provider for personalized advice on dosage, administration, and any potential interactions with other medications you may be taking. It’s important to attend regular follow-up appointments to monitor your cholesterol levels and adjust your treatment plan as needed.

Other uses for this medicine

In addition to its primary use in managing cholesterol levels and relieving itching associated with bile duct disorders, cholestyramine (Prevalite) may have other off-label uses. It has been explored in the management of diarrhea related to certain gastrointestinal conditions, such as bile acid malabsorption.

What special precautions should I follow?

Special precautions should be taken when using Prevalite, and it’s important to discuss your medical history and any other medications you are taking with your healthcare provider. Here are some key precautions:

• Allergies: Inform your healthcare provider if you have any allergies to cholestyramine or any other ingredients in Prevalite.
• Digestive Disorders: If you have a history of gastrointestinal disorders, such as constipation, blockages, or difficulty swallowing, discuss this with your healthcare provider before using Prevalite.
• Vitamin Deficiencies: Cholestyramine may interfere with the absorption of fat-soluble vitamins (A, D, E, K). Your healthcare provider may recommend vitamin supplements if needed.
• Other Medications: Cholestyramine can interact with other medications, reducing their absorption. Inform your healthcare provider about all prescription and over-the-counter medications, as well as any supplements, you are taking.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Prevalite with your healthcare provider.
• Kidney Function: Individuals with impaired kidney function may need dosage adjustments or careful monitoring when using cholestyramine.
• Blood Clotting Disorders: Cholestyramine may interfere with the absorption of certain anticoagulant medications. Inform your healthcare provider if you have a history of blood clotting disorders or are taking blood-thinning medications.
• Diabetes: Cholestyramine may affect blood sugar levels. Diabetic patients should monitor their blood sugar levels closely, and adjustments to diabetes medications may be necessary.

Always follow your healthcare provider’s instructions and attend regular check-ups to monitor your response to the medication. If you experience any unusual or severe side effects, contact your healthcare provider promptly. Do not stop or adjust your medication without consulting your healthcare professional.

What special dietary instructions should I follow?

• Low-Fat Diet: Follow a low-fat diet as recommended by your healthcare provider to enhance the effectiveness of Prevalite in reducing cholesterol levels.
• Separation from Other Medications: Take other medications at least 1 hour before or 4 to 6 hours after taking Prevalite to avoid interference with their absorption.

What should I do if I forget a dose?

• If you miss a dose, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do not double the dose to make up for a missed one.

What side effects can this medication cause?

Prevalite (cholestyramine) may cause side effects, and it’s important to be aware of potential adverse reactions. Not everyone will experience these side effects, and some individuals may tolerate the medication well. Common side effects include:

• Gastrointestinal Distress: The most common side effects are related to the gastrointestinal tract and may include constipation, flatulence (gas), bloating, stomach pain, and nausea.
• Vitamin Deficiencies: Cholestyramine can interfere with the absorption of fat-soluble vitamins (A, D, E, K), potentially leading to deficiencies. Your healthcare provider may recommend vitamin supplements.
• Decreased Absorption of Medications: Cholestyramine may interfere with the absorption of other medications, reducing their effectiveness. It’s important to take other medications at least 1 hour before or 4 to 6 hours after taking Prevalite.
• Allergic Reactions: While rare, some individuals may experience allergic reactions to cholestyramine. Seek medical attention if you develop symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Gastrointestinal Obstruction: In individuals with pre-existing gastrointestinal conditions, there may be a risk of intestinal obstruction, especially if the product is not mixed well with liquid before ingestion.
• Liver Function Abnormalities: There have been reports of liver function abnormalities in some patients taking cholestyramine. Your healthcare provider may monitor your liver function through blood tests.
• Increased Bleeding Risk: Cholestyramine may interfere with the absorption of vitamin K, potentially increasing the risk of bleeding in individuals taking anticoagulant medications.

It’s essential to report any unusual or severe side effects to your healthcare provider promptly. Additionally, inform your healthcare provider about all medications and supplements you are taking to minimize the risk of drug interactions.

This is not an exhaustive list of side effects, and individual responses may vary. Always follow your healthcare provider’s instructions, and if you have any concerns about the side effects of Prevalite, discuss them with your healthcare professional.

What should I know about storage and disposal of this medication?

Storage and Disposal of Prevalite:
Storage:

• Store Prevalite at room temperature away from moisture and heat.
• Keep it in its original container, tightly closed.

Disposal:

• Follow any specific disposal instructions provided by your healthcare provider or pharmacist.
• Do not flush medications down the toilet unless instructed to do so.
• Dispose of unused or expired medication in accordance with local regulations. Contact your local waste disposal facility for guidance on medication disposal.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention. Overdose symptoms may include severe constipation, stomach cramps, or difficulty swallowing.

What other information should I know?

• Regular Monitoring: Regularly monitor your cholesterol levels as directed by your healthcare provider to assess the effectiveness of Prevalite.
• Diet and Lifestyle: Follow a low-fat diet and make necessary lifestyle changes, including exercise, as recommended by your healthcare provider.
• Medication Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, as Prevalite may interact with them.
• Follow Instructions: Take Prevalite exactly as prescribed by your healthcare provider. Do not adjust the dose without consulting them.
• Medical Alert Bracelet: If you have a history of gastrointestinal disorders or other medical conditions, consider wearing a medical alert bracelet to inform healthcare providers in case of emergencies.
• Regular Follow-up: Attend regular follow-up appointments with your healthcare provider to monitor your response to the medication and make any necessary adjustments to your treatment plan.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Prevalite with your healthcare provider.
• Allergic Reactions: Be aware of allergic reaction symptoms, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek medical attention if you experience these symptoms.

Always consult your healthcare provider or pharmacist for specific guidance tailored to your individual health needs. This information serves as a general guide and does not replace professional medical advice.