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Prandimet (Generic Repaglinide)

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Why is this medication prescribed?

Repaglinide is an oral medication that belongs to a class of drugs known as meglitinides. It is prescribed to help control blood sugar levels in people with type 2 diabetes. Type 2 diabetes is a condition where the body does not produce enough insulin or does not use insulin effectively, leading to high blood sugar levels.

How should this medicine be used?

Here’s how Repaglinide works and how it is typically used:

  • Mechanism of Action: Repaglinide stimulates the release of insulin from the pancreas. It does this by binding to the beta cells in the pancreas, which then enhances the release of insulin. Insulin helps to lower blood sugar levels by facilitating the uptake of glucose into cells.
  • Prescription and Dosage: Repaglinide is usually prescribed as part of a comprehensive treatment plan for type 2 diabetes, which may include diet, exercise, and other medications. The dosage of Repaglinide varies from person to person and is determined by factors such as blood sugar levels and individual response to the medication.
  • Administration: It is typically taken orally before meals to control postprandial (after-meal) spikes in blood sugar. Repaglinide is generally taken within 15 minutes before each main meal (usually 2 to 4 times daily), but the specific instructions may vary depending on your doctor’s recommendations.
  • Monitoring: Regular monitoring of blood sugar levels is important while using Repaglinide to ensure that the medication is effectively controlling blood sugar without causing it to drop too low (hypoglycemia).
  • Missed Dose: If a dose is missed, it should be taken as soon as you remember. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed.
  • Precautions: It is important to follow your healthcare provider’s instructions carefully and to inform them of any other medications you are taking, as certain drugs can interact with Repaglinide. Additionally, individuals with liver problems should use Repaglinide cautiously, and the medication should not be used by people with type 1 diabetes or diabetic ketoacidosis.

Always consult with your healthcare provider for personalized advice regarding the use of Repaglinide or any other medication.

Other uses for this medicine

Repaglinide is primarily prescribed for the management of type 2 diabetes. It stimulates insulin release from the pancreas, helping to control blood sugar levels. However, it is not typically used for conditions other than diabetes. Its mechanism of action specifically targets glucose regulation in individuals with type 2 diabetes.

What special precautions should I follow?

Regarding special precautions for using Repaglinide, it’s important to follow your healthcare provider’s guidance closely. Here are some general precautions to consider:

  • Allergies: Inform your healthcare provider if you are allergic to Repaglinide or any other medications.
  • Medical Conditions: Before starting Repaglinide, discuss your medical history with your healthcare provider, especially if you have liver disease. Repaglinide is metabolized by the liver, so individuals with liver problems may need special consideration.
  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Repaglinide during pregnancy and breastfeeding is not well-established, and alternative treatments may be considered.
  • Interactions with Other Medications: Repaglinide can interact with other medications, including certain antibiotics, antifungals, and medications that affect liver enzymes. Inform your healthcare provider about all the medications, supplements, and herbal products you are taking.
  • Hypoglycemia (Low Blood Sugar): Repaglinide can cause hypoglycemia (low blood sugar). It’s important to monitor your blood sugar regularly and be aware of symptoms of low blood sugar, such as sweating, shakiness, dizziness, and confusion. Your healthcare provider will provide guidance on how to manage low blood sugar episodes.
  • Meal Timing: Repaglinide is typically taken before meals. Ensure that you take it within 15 minutes before your meals, as directed by your healthcare provider.
  • Missed Doses: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
  • Alcohol: Limit alcohol consumption, as it can increase the risk of hypoglycemia.

It’s crucial to have regular check-ups with your healthcare provider to monitor your diabetes management and adjust your treatment plan as needed. Always consult with your healthcare provider for personalized advice based on your specific health situation.

What special dietary instructions should I follow?

Special Dietary Instructions for Repaglinide:

  • Meal Timing: Repaglinide is most effective when taken before meals. It’s crucial to follow the prescribed meal schedule.
  • Balanced Diet: Maintain a balanced diet as recommended by your healthcare provider or a registered dietitian. This can help in managing blood sugar levels.
  • Consistency in Carbohydrate Intake: Try to be consistent with the amount and timing of carbohydrate intake in your meals to help regulate blood sugar levels.

What should I do if I forget a dose?

If you forget to take a dose of Repaglinide, follow these general guidelines:

  • Take it as Soon as You Remember: If you remember within a short time frame (before the next scheduled dose), take the missed dose as soon as possible.
  • Skip the Dose if It’s Close to the Next: If it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
  • Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking too much Repaglinide at once can increase the risk of hypoglycemia.

Always consult with your healthcare provider if you have questions about missed doses or if you are unsure about how to proceed. They can provide personalized guidance based on your specific health situation.

What side effects can this medication cause?

As with any medication, Repaglinide may cause side effects. It’s important to note that not everyone will experience these side effects, and some people may experience different side effects to varying degrees. If you are prescribed Repaglinide and are concerned about potential side effects, it’s recommended to discuss your specific situation with your healthcare provider. Here are some common side effects associated with Repaglinide:

  • Hypoglycemia (Low Blood Sugar): One of the most common side effects of Repaglinide is hypoglycemia. This can cause symptoms such as sweating, shakiness, dizziness, irritability, headache, and confusion. It’s important to monitor blood sugar levels regularly and be aware of the signs of low blood sugar.
  • Weight Gain: Some individuals may experience weight gain while taking Repaglinide.
  • Upper Respiratory Tract Infections: Respiratory infections, such as the common cold, may occur.
  • Flu-like Symptoms: Some people may experience flu-like symptoms, including a sore throat and sinus congestion.
  • Back Pain: Repaglinide has been associated with back pain in some cases.
  • Gastrointestinal Issues: Digestive system side effects may include nausea, diarrhea, and abdominal pain.
  • Allergic Reactions: Although rare, allergic reactions to Repaglinide can occur. Seek medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
  • Liver Function: There have been reports of changes in liver function tests in some individuals taking Repaglinide. Your healthcare provider may monitor your liver function periodically.

It’s important to report any unusual or severe side effects to your healthcare provider promptly. Additionally, before starting Repaglinide, inform your healthcare provider about any existing medical conditions and medications you are taking, as this information can help them assess potential risks and benefits.

This list is not exhaustive, and individual responses to medications can vary. Always follow your healthcare provider’s instructions, and if you have concerns or experience any side effects, seek guidance from your healthcare team.

What should I know about storage and disposal of this medication?

Storage and Disposal of Repaglinide:

  • Store Repaglinide at room temperature, away from excessive heat and moisture.
  • Keep it in its original packaging to protect it from light.
  • Avoid storing it in the bathroom.


  • Dispose of Repaglinide according to local regulations and guidelines.
  • Do not flush medications down the toilet unless instructed to do so.
  • Consult your healthcare provider or pharmacist for guidance on proper disposal.

In case of emergency/overdose

In the event of an overdose or if you suspect someone has taken too much Repaglinide, seek emergency medical attention or contact a poison control center immediately. Signs of an overdose may include symptoms of hypoglycemia (low blood sugar), such as sweating, shakiness, confusion, and fainting. Provide the healthcare professionals with as much information as possible, including the amount of Repaglinide ingested and the person’s current health status.

What other information should I know?

  • Regular Monitoring: Regularly monitor your blood sugar levels as directed by your healthcare provider.
  • Follow-up Appointments: Keep scheduled follow-up appointments with your healthcare provider to assess the effectiveness of the medication and make any necessary adjustments to your treatment plan.
  • Lab Tests: Your healthcare provider may order periodic blood tests to check your liver function while you are taking Repaglinide.
  • Avoid Alcohol: Limit alcohol consumption, as it can increase the risk of hypoglycemia.
  • Inform Healthcare Providers: Make sure all healthcare providers involved in your care are aware that you are taking Repaglinide, including dentists and emergency medical personnel.
  • Missed Doses: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
  • Diet and Exercise: Follow any dietary and exercise recommendations provided by your healthcare provider. These are important components of managing diabetes.

Always consult with your healthcare provider or pharmacist if you have specific questions about Repaglinide or if you experience any unexpected effects. It’s crucial to communicate openly with your healthcare team to ensure the safe and effective use of this medication in managing your diabetes.

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