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Praluent (Generic Alirocumab Injection)

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Why is this medication prescribed?

Praluent (alirocumab) is a medication used to treat high cholesterol. It belongs to a class of drugs known as PCSK9 inhibitors. High levels of low-density lipoprotein (LDL) cholesterol, often referred to as “bad” cholesterol, can contribute to the development of cardiovascular diseases such as heart attacks and strokes. Praluent helps lower LDL cholesterol levels by inhibiting the action of PCSK9, a protein that plays a role in cholesterol regulation.

How should this medicine be used?

The information provided here is general in nature, and it is crucial to follow the specific dosing and administration instructions provided by your healthcare provider. The following general guidelines may apply to the use of Praluent (alirocumab):

  • Administration: Praluent is typically administered as a subcutaneous injection, which means it is injected under the skin. Healthcare providers often provide instructions and training on how to self-administer the injections.
  • Frequency: The frequency of Praluent injections can vary depending on the prescribed dosage and the individual’s response to the medication. It may be administered once every two weeks or once a month.
  • Dosage: The prescribed dosage of Praluent is determined by the healthcare provider based on the patient’s specific medical condition, cholesterol levels, and other factors.
  • Injection Sites: Praluent injections are commonly administered in the thigh or abdomen. Healthcare providers may recommend rotating injection sites to minimize the risk of injection site reactions.
  • Storage: Praluent should be stored according to the manufacturer’s instructions, typically in the refrigerator. It is important to check the medication’s expiration date and not use it if it has expired.

It’s crucial to attend regular follow-up appointments with your healthcare provider while taking Praluent to monitor your cholesterol levels and assess the medication’s effectiveness and any potential side effects.

Always follow your healthcare provider’s instructions and reach out to them if you have any questions or concerns about the use of Praluent. Additionally, be aware that there may have been updates or changes to the prescribing information since last update, so consulting with a healthcare professional or referring to the latest medical sources is essential for the most current information.

Other uses for this medicine

Praluent (alirocumab) is primarily prescribed for the treatment of high cholesterol, specifically to lower low-density lipoprotein (LDL) cholesterol levels. It is a PCSK9 inhibitor designed to reduce the risk of cardiovascular events such as heart attacks and strokes in patients with hypercholesterolemia.

What special precautions should I follow?

Special precautions for using Praluent may include:

  • Hypersensitivity: Inform your healthcare provider if you have a history of hypersensitivity or allergic reactions to Praluent or any of its components.
  • Infections: If you develop signs of infection, such as fever, redness, swelling, or tenderness at the injection site, contact your healthcare provider promptly.
  • Liver function: Praluent may affect liver enzymes, so regular monitoring of liver function may be necessary. Inform your healthcare provider of any existing liver conditions or if you experience symptoms of liver problems.
  • Pregnancy and breastfeeding: The safety of Praluent during pregnancy and breastfeeding is not well-established. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
  • Interactions with other medications: Inform your healthcare provider about all the medications, including prescription and over-the-counter drugs, as well as dietary supplements, that you are currently taking. Certain medications may interact with Praluent.
  • Muscle symptoms: Report any unexplained muscle pain, weakness, or tenderness to your healthcare provider, as these symptoms may be indicative of a serious condition known as myopathy.
  • Immunizations: Inform your healthcare provider if you are scheduled to receive any vaccinations, as the use of Praluent may affect the immune response to certain vaccines.

Always follow your healthcare provider’s instructions and attend regular check-ups to monitor your response to Praluent and address any potential side effects or concerns. Additionally, since medical information may have changed since my last update, consult with your healthcare provider or refer to the latest medical literature for the most current information on Praluent.

What special dietary instructions should I follow?

Praluent is not typically associated with specific dietary restrictions. However, maintaining a heart-healthy diet as advised by your healthcare provider is essential when managing high cholesterol. This may include:

  • Reducing saturated and trans fats: Limit intake of foods high in saturated and trans fats, such as red meat, processed foods, and fried foods.
  • Increasing fiber intake: Include fruits, vegetables, and whole grains in your diet to promote heart health.
  • Limiting cholesterol intake: Limit dietary cholesterol intake by choosing lean proteins and incorporating more plant-based sources.

Always follow your healthcare provider’s dietary recommendations tailored to your specific health needs.

What should I do if I forget a dose?

If you forget to take a dose of Praluent, contact your healthcare provider for guidance. It’s essential not to double up on doses unless specifically instructed to do so. Your healthcare provider may provide instructions on when to take the missed dose or adjust your dosing schedule accordingly.

What side effects can this medication cause?

Praluent (alirocumab) is generally well-tolerated, but like any medication, it may cause side effects. Not everyone will experience these side effects, and some individuals may experience no side effects at all. Common side effects and more serious reactions associated with Praluent can include:

Common Side Effects:

  • Injection Site Reactions: Redness, itching, swelling, or pain at the injection site are common and usually mild.
  • Flu-Like Symptoms: Some people may experience symptoms such as fever, chills, or muscle aches.
  • Nasopharyngitis: Inflammation of the nose and throat, causing symptoms like a runny or stuffy nose.

Serious Side Effects:

  • Allergic Reactions: While rare, some individuals may experience serious allergic reactions to Praluent. Seek immediate medical attention if you notice signs of an allergic reaction, such as difficulty breathing, severe dizziness, or swelling of the face/tongue.
  • Liver Problems: In some cases, Praluent may affect liver function. Contact your healthcare provider if you experience symptoms such as persistent nausea, yellowing of the eyes or skin (jaundice), dark urine, or abdominal pain.
  • Muscle Symptoms: Unexplained muscle pain, tenderness, or weakness could be indicative of a serious condition known as myopathy. Report these symptoms to your healthcare provider promptly.

It’s important to note that this is not an exhaustive list of side effects, and individual responses to medications can vary. Additionally, new information may have emerged since last update. If you are prescribed Praluent and experience any unusual or severe side effects, contact your healthcare provider promptly. They can provide guidance, adjust your treatment plan if necessary, or address any concerns you may have. Always follow your healthcare provider’s instructions and attend regular check-ups to monitor your response to the medication.

What should I know about storage and disposal of this medication?

Here are some general guidelines regarding the storage, disposal, emergency/overdose procedures, and additional information about Praluent (alirocumab). However, it’s crucial to follow the specific instructions provided by your healthcare provider and refer to the medication’s latest prescribing information or contact a healthcare professional for the most up-to-date advice.

Refrigeration: Praluent is often stored in the refrigerator. Follow the specific storage instructions provided with your medication. Do not freeze.

Expiration Date: Check the expiration date on the medication packaging. Do not use Praluent if it has expired.


Unused Medication: If you have unused or expired Praluent, consult your healthcare provider or pharmacist regarding proper disposal methods. Do not dispose of it in household trash without guidance.

In case of emergency/overdose

  • Seek Medical Attention: In the case of an overdose or if you suspect an adverse reaction, seek emergency medical attention immediately.
  • Symptoms of Overdose: Symptoms of an overdose may include severe allergic reactions, muscle pain, weakness, or other severe side effects. Prompt medical attention is essential.

What other information should I know?

Regular Monitoring: Attend regular follow-up appointments with your healthcare provider to monitor your response to Praluent and assess its effectiveness.

Lab Tests: Your healthcare provider may order regular blood tests, including tests for liver function, while you are taking Praluent.

Informing Healthcare Providers: Inform all healthcare professionals involved in your care, including dentists and emergency room personnel, that you are taking Praluent.

Drug Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as dietary supplements, that you are currently taking, as Praluent may interact with certain medications.

Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider, as the safety of Praluent in these situations may not be well-established.

Always follow the guidance of your healthcare provider and the instructions provided with the medication. If you have specific questions or concerns about Praluent, consult with your healthcare professional for personalized advice based on your health condition and the most current medical information available.

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