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Pralatrexate Injection

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Why is this medication prescribed?

Pralatrexate is a medication prescribed for the treatment of a type of cancer known as peripheral T-cell lymphoma (PTCL). PTCL is a rare and aggressive form of non-Hodgkin lymphoma that affects T cells, a type of white blood cell. Pralatrexate is specifically indicated for relapsed or refractory PTCL, meaning it is used when the cancer has come back after previous treatment or has not responded to other treatments.

How should this medicine be used?

The following information provides a general overview of the usage of Pralatrexate Injection. However, it’s essential to note that specific instructions may vary based on individual patient factors, the type and stage of cancer, and the prescribing physician’s recommendations. Always follow your healthcare provider’s instructions precisely.

  • Administration: Pralatrexate is typically administered by a healthcare professional in a clinical setting, such as a hospital or a doctor’s office. It is given as an intravenous (IV) infusion, which means it is injected directly into a vein.
  • Dosage and Schedule: The dosage and treatment schedule are determined by the prescribing physician based on factors such as the type of cancer, its stage, and the patient’s overall health. It is crucial to follow the recommended dosage and schedule provided by the healthcare provider.
  • Frequency of Administration: Pralatrexate is often administered once a week for a specified number of weeks, followed by a rest period. This cycle may be repeated as needed, depending on the patient’s response to treatment and the progression of the disease.
  • Pre-treatment Measures: Prior to each administration, the healthcare team may conduct blood tests to assess the patient’s blood cell counts and overall health. Depending on the results, adjustments to the dosage or treatment schedule may be made.
  • Precautions: Patients should inform their healthcare provider about any existing medical conditions, medications, or allergies before starting Pralatrexate. This information is crucial for ensuring the safety and efficacy of the treatment.
  • Side Effects Management: Pralatrexate may cause side effects, and patients should be monitored for any adverse reactions. Common side effects may include nausea, fatigue, decreased appetite, and changes in blood cell counts. If side effects occur, they should be promptly reported to the healthcare team.
  • Follow-up Appointments: Regular follow-up appointments will be scheduled to monitor the patient’s response to treatment, assess any side effects, and make any necessary adjustments to the treatment plan.

It’s important to note that the information provided here is a general guideline, and individualized instructions should always be obtained from the prescribing healthcare professional. If you have any questions or concerns about the use of Pralatrexate Injection, discuss them with your healthcare provider for personalized guidance.

Other uses for this medicine

Pralatrexate Injection is primarily indicated for the treatment of peripheral T-cell lymphoma (PTCL) in patients who have relapsed or refractory disease. It is a targeted chemotherapy drug, and its use is generally limited to this specific condition. There may have been updates or additional indications since then, so it’s crucial to consult with a healthcare professional or refer to the latest medical literature for the most current information.

What special precautions should I follow?

Regarding special precautions for Pralatrexate Injection, it is essential to follow your healthcare provider’s advice closely and be aware of the following considerations:

  • Medical History: Before starting Pralatrexate, inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or previous reactions to medications.
  • Pregnancy and Breastfeeding: Pralatrexate may harm an unborn baby, so it is important to discuss pregnancy plans with your healthcare provider. If you are pregnant or breastfeeding, the risks and benefits of using Pralatrexate should be carefully evaluated.
  • Liver and Kidney Function: Pralatrexate is eliminated from the body through the kidneys and liver. Your healthcare provider may assess your kidney and liver function before and during treatment to ensure that the drug is appropriately metabolized.
  • Blood Cell Counts: Pralatrexate can affect blood cell counts, including white blood cells, red blood cells, and platelets. Regular blood tests may be conducted to monitor these counts, and dosage adjustments may be made accordingly.
  • Infections: Pralatrexate may increase the risk of infections. Notify your healthcare provider if you experience symptoms of infection, such as fever, chills, or persistent sore throat.
  • Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking. Some drugs may interact with Pralatrexate, affecting its effectiveness or increasing the risk of side effects.
  • Sun Exposure: Pralatrexate may make your skin more sensitive to sunlight. It is advisable to use sun protection measures, such as sunscreen and protective clothing, to minimize the risk of sunburn.
  • Side Effects: Be aware of potential side effects of Pralatrexate, and promptly report any unusual or severe symptoms to your healthcare provider. Common side effects may include nausea, fatigue, and mucositis (inflammation of the mucous membranes).

Remember, individual patient circumstances may vary, and these precautions are general guidelines. Always consult with your healthcare provider for personalized advice and information specific to your medical condition and treatment plan.

What special dietary instructions should I follow?

Special Dietary Instructions:

  • Folic Acid Supplementation: Your healthcare provider may recommend folic acid supplementation to help reduce certain side effects of Pralatrexate. Follow their recommendations regarding folic acid intake.
  • Hydration: Staying well-hydrated is often important during cancer treatment. Your healthcare provider may provide specific hydration guidelines.

What should I do if I forget a dose?

  • Contact Your Healthcare Provider: If you forget a dose of Pralatrexate, contact your healthcare provider immediately. They will provide guidance on how to proceed, which may include adjusting the schedule or dosage.
  • Do Not Double Dose: Do not take a double dose to make up for a missed one, as this can increase the risk of side effects.
  • Follow Instructions: Follow your healthcare provider’s instructions for missed doses carefully. They may provide specific guidance based on your individual treatment plan.

What side effects can this medication cause?

Pralatrexate Injection, like many chemotherapy medications, can cause various side effects. It’s important to note that not all individuals will experience the same side effects, and the severity can vary. Common side effects of Pralatrexate include:

  • Nausea and Vomiting: Pralatrexate can cause nausea and vomiting. Your healthcare provider may prescribe anti-nausea medications to help manage these symptoms.
  • Fatigue: Feeling tired or fatigued is a common side effect of Pralatrexate treatment. Adequate rest and pacing yourself may help alleviate fatigue.
  • Mucositis: Inflammation of the mucous membranes, known as mucositis, may occur. This can lead to soreness or ulcers in the mouth and throat.
  • Decreased Appetite: Some individuals may experience a decrease in appetite while undergoing Pralatrexate treatment.
  • Changes in Blood Cell Counts: Pralatrexate can affect the bone marrow, leading to changes in blood cell counts. This may result in an increased risk of infections (due to low white blood cell count), anemia (due to low red blood cell count), and bleeding or bruising tendencies (due to low platelet count).
  • Liver Enzyme Abnormalities: Pralatrexate may cause elevated levels of liver enzymes. Regular monitoring of liver function through blood tests is typically performed.
  • Skin Reactions: Skin reactions, such as rash or redness, may occur.
  • Kidney Function: Pralatrexate is eliminated through the kidneys, and some patients may experience changes in kidney function.
  • Folic Acid Deficiency: Pralatrexate inhibits the action of folic acid, which is necessary for normal cell function. To mitigate this, folic acid supplementation is often prescribed.
  • Infections: There may be an increased risk of infections due to the impact of Pralatrexate on the immune system.

It’s crucial to report any side effects or symptoms to your healthcare provider promptly. They can provide guidance on managing side effects and may adjust the treatment plan if necessary. In some cases, supportive medications may be prescribed to alleviate specific side effects.

It’s important to keep in mind that the benefits of Pralatrexate treatment in managing cancer often outweigh the potential side effects. Your healthcare team will monitor your response to treatment and work with you to manage any side effects effectively. Always follow your healthcare provider’s instructions and communicate openly about any concerns you may have.

What should I know about storage and disposal of this medication?

Storage and Disposal of Pralatrexate Injection:

  • Storage: Pralatrexate Injection is typically stored by healthcare professionals in a controlled environment, such as a hospital or clinic. It is important to follow the storage guidelines provided by the healthcare facility or pharmacist.
  • Disposal: Proper disposal of medical waste, including empty vials and syringes used for Pralatrexate Injection, is crucial. Healthcare providers or facilities usually have specific protocols for the safe disposal of medical waste. Do not dispose of medications in household trash or wastewater unless specifically instructed to do so.

In case of emergency/overdose

In case of an emergency or suspected overdose of Pralatrexate Injection, seek immediate medical attention. The symptoms of an overdose may include severe nausea, vomiting, or other adverse reactions. It’s important to contact your local poison control center or emergency room for guidance.

What other information should I know?

  • Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. These appointments allow the healthcare team to monitor your response to treatment, assess for potential side effects, and make any necessary adjustments to your treatment plan.
  • Lab Tests: Regular blood tests and other laboratory assessments are often conducted during Pralatrexate treatment to monitor blood cell counts, liver function, and other relevant parameters.
  • Inform Healthcare Providers: Make sure all your healthcare providers are aware of your Pralatrexate treatment, including your oncologist, primary care physician, and any specialists you may see. This ensures comprehensive and coordinated care.
  • Medication Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as certain medications may interact with Pralatrexate.
  • Pregnancy and Contraception: Pralatrexate may cause harm to an unborn baby. If you are pregnant or planning to become pregnant, discuss this with your healthcare provider, and appropriate contraceptive measures may be recommended.
  • Breastfeeding: Breastfeeding is not recommended during Pralatrexate treatment, as the drug may be excreted in breast milk and could harm the nursing infant.

Always consult with your healthcare provider for specific guidance and information tailored to your individual situation. Your healthcare team is your primary source of information and support throughout your Pralatrexate treatment.

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