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Polivy (Generic Polatuzumab vedotin-piiq Injection)

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Why is this medication prescribed?

Polivy (polatuzumab vedotin) is a prescription medication used in the treatment of certain types of non-Hodgkin lymphoma (NHL). It is specifically indicated for use in combination with other medications for adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma.

Polivy is a type of antibody-drug conjugate. It consists of an anti-CD79b antibody linked to a chemotherapy drug (monomethyl auristatin E or MMAE). CD79b is a protein found on the surface of B-cells, which are a type of immune system cell. Polivy targets and binds to these B-cells, delivering the chemotherapy drug directly to them to help destroy the cancer cells.

How should this medicine be used?

Polivy is typically administered as part of a combination regimen for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma. The specific regimen and dosage may be determined by the treating oncologist based on the patient’s condition.

Here is a general overview of the administration of Polivy:

  • Administration Setting: Polivy is administered intravenously (IV) by a healthcare professional in a clinical setting, such as a hospital or infusion center.
  • Combination Regimen: Polivy is usually given in combination with other medications. The combination therapy may include other chemotherapy drugs and possibly immunotherapy agents. The specific drugs and regimen will be determined by the oncologist.
  • Dosage and Schedule: The dosage and schedule of Polivy administration can vary. The healthcare provider will determine the appropriate dosage and frequency based on factors such as the patient’s weight, overall health, and the specific treatment plan.
  • Monitoring: Patients receiving Polivy will be closely monitored for any potential side effects or adverse reactions during and after the infusion. Regular blood tests and other assessments may be conducted to ensure the patient’s well-being.
  • Preparation and Administration: Polivy is usually prepared and administered by healthcare professionals trained in handling chemotherapy medications. It is important to follow proper handling and safety procedures to minimize the risk of exposure.

It’s crucial to communicate openly with the healthcare team about any concerns, side effects, or changes in health during and after Polivy treatment. If you have been prescribed Polivy or any other medication, consult your healthcare provider for specific and personalized instructions tailored to your medical condition.

Other uses for this medicine

Polivy (polatuzumab vedotin) is primarily indicated for the treatment of specific types of non-Hodgkin lymphoma, specifically relapsed or refractory diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma. The approval and recommended uses of medications may change over time, so it’s important to check with a healthcare professional or refer to the latest prescribing information for the most up-to-date details.

What special precautions should I follow?

Regarding special precautions for Polivy, it’s crucial to follow the guidance provided by the prescribing healthcare provider. The following are general considerations, but individual circumstances may vary:

  • Pre-existing Conditions: Inform your healthcare provider about any pre-existing medical conditions, including heart problems, liver disease, lung disease, or any other significant health issues.
  • Pregnancy and Breastfeeding: Polivy may cause harm to an unborn baby, so it is important to inform your healthcare provider if you are pregnant or planning to become pregnant. Breastfeeding should be avoided during treatment with Polivy.
  • Infections: Polivy can increase the risk of infections, and precautions should be taken to avoid exposure to infections. Inform your healthcare provider if you have a history of infections or any ongoing infections.
  • Blood Disorders: Polivy may affect blood cell counts, leading to a higher risk of anemia, neutropenia, and thrombocytopenia. Regular blood tests will be conducted to monitor blood cell counts during treatment.
  • Infusion Reactions: Infusion reactions, including fever, chills, and difficulty breathing, may occur during or after the administration of Polivy. Healthcare providers will monitor patients closely during and after the infusion.
  • Peripheral Neuropathy: Polivy may cause peripheral neuropathy, which can result in symptoms such as tingling, numbness, and pain in the hands and feet. Report any symptoms to your healthcare provider.
  • Liver Function: Polivy may affect liver function, and regular liver function tests may be conducted during treatment.
  • Fertility: Polivy may impact fertility, and patients are advised to discuss fertility preservation options with their healthcare provider before starting treatment.

It’s important to attend all scheduled appointments, follow the prescribed treatment plan, and communicate openly with your healthcare team about any concerns or side effects you may be experiencing. If you have specific questions or need information about Polivy, consult with your healthcare provider or refer to the latest prescribing information for the medication.

What special dietary instructions should I follow?

There may not be specific dietary restrictions associated with Polivy. However, maintaining a healthy and well-balanced diet is generally advisable during cancer treatment. If you have concerns or questions about dietary considerations, it’s best to discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you miss a dose of Polivy, it’s important to contact your healthcare provider as soon as possible for guidance. Do not try to make up for a missed dose without consulting your healthcare team, as they will provide specific instructions based on your treatment plan.

What side effects can this medication cause?

Polivy (polatuzumab vedotin) may cause a range of side effects, and it’s important for patients to be aware of these potential effects. Keep in mind that individual responses to medications can vary, and not everyone will experience the same side effects. If you are prescribed Polivy, your healthcare provider will closely monitor you for any adverse reactions. Common side effects and serious adverse events associated with Polivy can include:

Common Side Effects:

  • Infusion-related reactions: Symptoms may include fever, chills, nausea, and difficulty breathing during or after the infusion.
  • Low blood cell counts: This may include low red blood cell count (anemia), low white blood cell count (neutropenia), and low platelet count (thrombocytopenia).
  • Peripheral neuropathy: Numbness, tingling, or pain in the hands and feet.
  • Fatigue: Feeling tired or weak.
  • Diarrhea: Changes in bowel habits.
  • Fever: Elevated body temperature.
  • Decreased appetite: Reduced desire to eat.

Serious Adverse Events:

  • Infections: Increased risk of infections due to low white blood cell counts.
  • Liver problems: Abnormal liver function tests.
  • Tumor lysis syndrome: Rapid breakdown of cancer cells leading to the release of substances into the bloodstream; this can cause kidney problems, heart rhythm issues, and other complications.
  • Pneumonitis: Inflammation of the lungs.
  • Infusion-related reactions: Severe reactions may occur, requiring immediate medical attention.
  • Progressive multifocal leukoencephalopathy (PML): A rare, serious viral infection affecting the brain.

It’s important for patients to report any side effects or changes in health to their healthcare provider promptly. Early detection and management of side effects are crucial for optimizing the effectiveness of the treatment and improving the overall well-being of the patient.

This is not an exhaustive list of side effects, and other effects may occur. If you have concerns about potential side effects or if you experience any unusual symptoms while taking Polivy, contact your healthcare provider immediately. They can provide guidance, adjust the treatment plan if necessary, or address any concerns you may have.

What should I know about storage and disposal of this medication?

Storage and Disposal of Polivy:


  • Refrigeration: Polivy is typically stored in the refrigerator. Follow the specific storage instructions provided by your healthcare provider or pharmacist.
  • Protect from Light: Some medications can be light-sensitive. Ensure that Polivy is stored in its original packaging or in a container that protects it from light.
  • Do Not Freeze: Do not freeze Polivy. Freezing can alter the medication’s composition and effectiveness.
  • Keep Out of Reach of Children: Store medications in a safe place, out of reach of children and pets.


  • Follow Guidelines: Follow your healthcare provider’s or pharmacist’s instructions for proper disposal of unused or expired medication.
  • Community Programs: Check if there are community programs or local guidelines for medication disposal. Some areas have take-back programs or special disposal instructions.
  • Do Not Flush: Do not flush medications down the toilet unless specifically instructed to do so by the medication packaging or accompanying literature.

In case of emergency/overdose

In case of emergency or suspected overdose, seek immediate medical attention. Contact your local poison control center (in the U.S., call 1-800-222-1222) or go to the nearest emergency room. Provide them with information about the medication taken, the amount, and any symptoms experienced.

What other information should I know?

  • Regular Monitoring: Attend all scheduled appointments for blood tests and other monitoring as recommended by your healthcare provider. This helps them assess your response to treatment and detect any potential side effects early.
  • Communication with Healthcare Provider: Inform your healthcare provider of any changes in your health, any new symptoms, or any concerns you may have during the course of treatment.
  • Patient Education: Educate yourself about Polivy, its purpose, potential side effects, and any precautions you need to take. This will help you make informed decisions and communicate effectively with your healthcare team.
  • Follow Instructions: Adhere to the prescribed dosage and schedule provided by your healthcare provider. If you have any questions or concerns about the medication, discuss them with your healthcare team.

Always consult with your healthcare provider or pharmacist for specific instructions related to the storage, disposal, and emergency situations associated with Polivy. They can provide personalized guidance based on your individual health needs and the specific treatment plan.

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