PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance!

Pluvicto (Generic Lutetium Lu 177 Vipivotide Tetraxetan Injection)

Actual product appearance may differ slightly.

Click the CARD below to print or take a screenshot on your mobile phone or tablet. There is no need to download another app!

If you would like to personalize your card enter your full name in the member name field below the card at this link and click the Update button.

Why is this medication prescribed?

Lutetium Lu 177 Vipivotide Tetraxetan Injection is prescribed for the treatment of certain types of neuroendocrine tumors (NETs). Neuroendocrine tumors are a group of rare tumors that can develop in various organs throughout the body, such as the pancreas, gastrointestinal tract, and lungs. These tumors express specific receptors called somatostatin receptors. Lutetium Lu 177 Vipivotide Tetraxetan is a radiopharmaceutical designed to target and deliver radiation directly to these somatostatin receptors on the surface of the tumor cells.

How should this medicine be used?

The medication consists of two components: lutetium-177, a radioactive isotope, and vipivotide tetraxetan, a peptide that binds to somatostatin receptors. The combination allows for the targeted delivery of radiation to the tumor cells, which can be effective in treating neuroendocrine tumors.

Lutetium Lu 177 Vipivotide Tetraxetan Injection is Used:

  • Administration: The injection is administered intravenously (into a vein) by a healthcare professional, typically in a specialized nuclear medicine or oncology setting.
  • Dosage: The dosage and frequency of Lutetium Lu 177 Vipivotide Tetraxetan depend on various factors, including the specific type and stage of neuroendocrine tumors, as well as the individual patient’s characteristics.
  • Preparation: Prior to the injection, patients may undergo pre-treatment imaging scans, such as SPECT/CT (Single-Photon Emission Computed Tomography/Computed Tomography) or PET/CT (Positron Emission Tomography/Computed Tomography), to identify and assess the somatostatin receptor expression in the tumors.
  • Precautions: Special precautions are taken to minimize radiation exposure to healthcare workers, caregivers, and other individuals who may come into close contact with the patient after the injection.
  • Monitoring: After the injection, patients are closely monitored for potential side effects, and follow-up imaging studies may be conducted to assess the response of the tumors to the treatment.

It’s important for patients to discuss the specific details of their treatment plan, including the rationale for using Lutetium Lu 177 Vipivotide Tetraxetan, with their healthcare provider. The decision to use this medication is typically based on factors such as the type and extent of neuroendocrine tumors, previous treatment history, and the overall health of the patient. Patients should also receive detailed instructions from their healthcare team regarding any necessary precautions and follow-up care.

Other uses for this medicine

Other uses for Lutetium Lu 177 Vipivotide Tetraxetan Injection may include:

  • Neuroendocrine Tumors (NETs): The primary and most established use of this radiopharmaceutical is in the treatment of neuroendocrine tumors.
  • Clinical Trials: Lutetium Lu 177 Vipivotide Tetraxetan may be investigated in clinical trials for its efficacy in other types of cancer or medical conditions.

What special precautions should I follow?

Lutetium Lu 177 Vipivotide Tetraxetan is a specialized radiopharmaceutical used in targeted radionuclide therapy. If you are undergoing or considering this treatment, it’s important to follow specific precautions to ensure your safety and the effectiveness of the therapy. Here are some general precautions that patients may be advised to take:

  • Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant or breastfeeding. Lutetium Lu 177 Vipivotide Tetraxetan can be harmful to a developing fetus, and breastfeeding may need to be temporarily discontinued.
  • Radiation Safety: Due to the radioactive nature of lutetium-177, precautions are taken to minimize radiation exposure to others. Limit close contact with infants, children, and pregnant women for a certain period following the injection. Your healthcare provider will provide specific guidelines.
  • Hydration: Adequate hydration is often recommended to help protect the kidneys from potential toxicity. Drinking plenty of fluids before and after the injection can help flush the radioactive substance from your system.
  • Monitoring: Regular blood tests may be required to monitor your blood cell counts, kidney function, and liver enzymes. This helps your healthcare team assess your body’s response to the treatment and make any necessary adjustments.
  • Symptom Management: Inform your healthcare team about any side effects or symptoms you may experience, such as nausea, vomiting, pain, or fatigue. They can provide guidance on managing these symptoms and may adjust your treatment plan if necessary.
  • Follow-Up Imaging: Follow-up imaging studies, such as scans, may be scheduled to assess the response of the tumors to the treatment.
  • Isolation Precautions: In some cases, patients may be advised to follow isolation precautions for a certain period after receiving the injection to minimize radiation exposure to others. This may include specific instructions about using separate bathroom facilities and limiting close contact with others.
  • Medical History and Medications: Provide a comprehensive medical history to your healthcare team, including information about any pre-existing conditions and medications you are currently taking. Some medications may need to be adjusted or temporarily discontinued during the treatment.

It’s crucial to discuss these precautions and any specific guidelines with your healthcare provider before and after receiving Lutetium Lu 177 Vipivotide Tetraxetan. They will provide personalized recommendations based on your individual health status and the specific details of your treatment plan.

What special dietary instructions should I follow?

Specific dietary instructions for Lutetium Lu 177 Vipivotide Tetraxetan Injection, if applicable, would be provided by your healthcare provider. Certain medications may have dietary considerations, such as avoiding certain foods or substances that could interact with the drug.

What should I do if I forget a dose?

If you forget a dose of any medication, it is crucial to contact your healthcare provider promptly for guidance. Missing a dose can have implications for the effectiveness of the treatment, and your healthcare provider can provide specific advice based on your situation.

What side effects can this medication cause?

Lutetium Lu 177 Vipivotide Tetraxetan is a radiopharmaceutical used in targeted radionuclide therapy, primarily for the treatment of certain types of neuroendocrine tumors. The medication combines a radioactive isotope, lutetium-177, with a peptide (vipivotide tetraxetan) that binds to specific receptors on the tumor cells. While this treatment can be effective, it may also be associated with some side effects. It’s important to note that individual responses can vary, and not everyone will experience the same side effects. Common side effects of Lutetium Lu 177 Vipivotide Tetraxetan may include:

  • Nausea and Vomiting: These are relatively common side effects and can often be managed with medications prescribed by your healthcare provider.
  • Fatigue: Patients may experience increased tiredness or weakness during and after treatment.
  • Hematologic Toxicity: This refers to changes in blood cell counts, including a decrease in white blood cells, red blood cells, and platelets. This may lead to an increased risk of infection, anemia, and bleeding.
  • Kidney Toxicity: Lutetium Lu 177 is excreted through the kidneys, and there is a potential risk of renal (kidney) toxicity. Adequate hydration before and after treatment is often recommended to help protect the kidneys.
  • Liver Toxicity: Some patients may experience elevated liver enzymes.
  • Pain at the Injection Site: Discomfort or pain at the site where the injection is administered is possible.
  • Gastrointestinal Effects: Diarrhea and abdominal pain may occur.

It’s essential to communicate any side effects or concerns promptly with your healthcare team. They can provide guidance on managing side effects and adjust the treatment plan if necessary. Additionally, the benefits of the treatment, in terms of controlling or shrinking tumors, will be weighed against potential side effects. This information is not exhaustive, and the specific risks and side effects should be discussed with your healthcare provider based on your individual health status and medical history.

What should I know about storage and disposal of this medication?

Storage and Disposal of Lutetium Lu 177 Vipivotide Tetraxetan Injection:


  • Professional Handling: Lutetium Lu 177 Vipivotide Tetraxetan Injection should be handled and administered by healthcare professionals trained in the safe use of radiopharmaceuticals.
  • Radiation Safety: Store the injection in a controlled and secure environment that complies with regulations for the safe storage of radioactive materials.
  • Temperature Control: Follow the storage instructions provided by the manufacturer, paying attention to recommended temperature ranges.


  • Radiation Safety Measures: Dispose of any unused portions or empty vials according to local regulations for radioactive waste disposal.
  • Authorized Facilities: Dispose of radioactive materials only in facilities authorized to handle such waste. This is crucial to prevent environmental contamination and ensure public safety.

In case of emergency/overdose

  • Contact Healthcare Provider: In case of an emergency or suspected overdose, contact your healthcare provider or seek medical attention immediately.
  • Radiation Safety Protocols: Follow established radiation safety protocols for managing accidental exposure. Healthcare providers will have procedures in place to address potential radiation exposure incidents.

What other information should I know?

  • Patient Information: Patients should be informed about the purpose of the procedure, potential side effects, and any necessary preparations or post-procedure care.
  • Pregnancy and Breastfeeding: If there is a possibility of pregnancy, breastfeeding, or plans for pregnancy, inform healthcare providers, as there may be specific precautions to take.
  • Follow-up Monitoring: Regular follow-up appointments may be necessary to assess the patient’s response to treatment and monitor for any delayed side effects.
  • Compliance with Regulations: Ensure compliance with local, state, and national regulations governing the use, storage, and disposal of radioactive materials.
  • Patient Communication: Open communication between healthcare providers and patients is essential. Patients should feel comfortable asking questions and expressing any concerns related to the procedure.

Always follow the specific guidance provided by healthcare professionals, including the facility’s protocols and guidelines, to ensure the safe handling, storage, and disposal of Lutetium Lu 177 Vipivotide Tetraxetan Injection.

Copyright © 2023