WARNING

Taking Pexidartinib, like any medication, involves certain risks and potential side effects. It’s important to note that the following information is not exhaustive, and individual experiences may vary. Always consult with your healthcare provider for personalized advice. Some potential risks associated with Pexidartinib include:

• Liver Function Changes: Pexidartinib may affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function is typically recommended.
• Increased Blood Pressure: Pexidartinib can cause an increase in blood pressure.
• Peripheral Edema: Swelling in the hands or feet (peripheral edema) may occur.
• Changes in Blood Cell Counts: Pexidartinib can affect blood cell counts, leading to changes in white blood cells, red blood cells, and platelets.
• Hair Color Changes: Some patients may experience changes in hair color.
• Fatigue: Feeling tired or fatigued may occur.
• Nausea: Nausea is a common side effect of Pexidartinib.
• Musculoskeletal Pain: Pain in the muscles or joints may be a side effect.

It’s essential to inform your healthcare provider of any existing medical conditions, allergies, or medications you are taking to assess the overall risk-benefit profile for your specific situation. Regular monitoring and communication with your healthcare provider can help manage potential risks and ensure the safe and effective use of Pexidartinib. If you experience any concerning symptoms or side effects, contact your healthcare provider promptly.

Why is this medication prescribed?

Pexidartinib is a medication primarily used for the treatment of symptomatic tenosynovial giant cell tumors (TGCT) in adults. Tenosynovial giant cell tumors are rare, benign tumors that typically affect the synovium-lined joints, bursae, and tendon sheaths. These tumors can cause pain, swelling, and limited range of motion in the affected joints.

Pexidartinib is a tyrosine kinase inhibitor that works by targeting specific enzymes involved in the growth of tumor cells. It is typically prescribed when surgical removal of the tumor is not feasible or when the tumor is recurrent.

How should this medicine be used?

The information provided here is a general guideline for the use of Pexidartinib, and it is important to follow the specific instructions given by your healthcare provider. Dosage and administration may vary based on individual health conditions, and your healthcare provider will determine the appropriate treatment plan for you.

General Guidelines for Pexidartinib Use:

• Dosage: Take Pexidartinib exactly as prescribed by your healthcare provider. Do not change the dosage without consulting your healthcare professional.
• Administration: Pexidartinib is typically taken orally, with or without food. Follow your healthcare provider’s instructions on how to take the medication.
• Regular Schedule: Take Pexidartinib at the same time each day to maintain a consistent level of the medication in your system.
• Do Not Crush or Split: Swallow the whole tablet with water. Do not crush, chew, or split the tablet unless your healthcare provider advises otherwise.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses to make up for a missed one.
• Follow-up Appointments: Attend all follow-up appointments with your healthcare provider. They may monitor your response to the medication and perform necessary tests.
• Liver Function Monitoring: Pexidartinib may affect liver function. Your healthcare provider may order periodic liver function tests to monitor for any changes.
• Special Precautions: Follow any special precautions provided by your healthcare provider, such as dietary restrictions or other specific instructions.
• Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.

Always consult with your healthcare provider or pharmacist for the most accurate and up-to-date information regarding the use of Pexidartinib, and report any concerns or side effects promptly.

Other uses for this medicine

Pexidartinib is primarily indicated for the treatment of symptomatic tenosynovial giant cell tumors (TGCT) in adults. The information provided here may not reflect any new developments or changes in indications that may have occurred since then. It’s crucial to consult with a healthcare professional or refer to the latest medical resources for the most up-to-date information.

What special precautions should I follow?

Regarding special precautions for pexidartinib, it’s important to note that any medication can have potential side effects and interactions. Before starting pexidartinib or any medication, it’s essential to inform your healthcare provider about your medical history, including any allergies, current medications (prescription and over-the-counter), and any pre-existing conditions.

Here are some general precautions that might be associated with pexidartinib:

• Liver Function Monitoring: Pexidartinib can affect liver function, and periodic monitoring of liver function tests may be necessary. Your healthcare provider may order blood tests to check liver enzymes regularly.
• Drug Interactions: Pexidartinib may interact with other medications you are taking. Inform your healthcare provider about all the medications, supplements, and herbal products you are using.
• Pregnancy and Breastfeeding: The safety of pexidartinib during pregnancy and breastfeeding is not well-established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits with your healthcare provider.
• Adverse Reactions: Be aware of potential side effects of pexidartinib and report any unusual or severe symptoms to your healthcare provider promptly.
• Special Populations: Pexidartinib may need to be used with caution in patients with certain pre-existing conditions. Your healthcare provider will assess the risks and benefits based on your individual health status.

Always follow your healthcare provider’s instructions and guidance, and do not hesitate to reach out if you have any concerns or questions about your medication. Additionally, for the latest information on pexidartinib, consult your healthcare provider or refer to the prescribing information provided with the medication.

What special dietary instructions should I follow?

There were no specific dietary restrictions mentioned for Pexidartinib. However, it’s always advisable to follow any dietary instructions provided by your healthcare provider or pharmacist. If there have been updates or changes in the recommendations since then, your healthcare provider will inform you.

What should I do if I forget a dose?

If you forget to take a dose of Pexidartinib, it’s important to follow the instructions provided by your healthcare provider or the prescribing information. In general, if you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Pexidartinib, like any medication, can cause side effects. It’s important to note that the following list is not exhaustive, and individual experiences may vary. Additionally, new information or updates may have occurred since last update. Always consult with your healthcare provider or refer to the most recent prescribing information for the most accurate and up-to-date information.

Common side effects of Pexidartinib may include:

• Changes in Liver Function: Pexidartinib can affect liver function, leading to elevated liver enzymes. Regular monitoring of liver function is typically recommended.
• Hair Color Changes: Some patients may experience changes in hair color.
• Fatigue: Feeling tired or fatigued may occur.
• Nausea: Nausea is a common side effect of Pexidartinib.
• Increased Blood Pressure: Pexidartinib may cause an increase in blood pressure.
• Peripheral Edema: Swelling in the hands or feet (peripheral edema) may occur.
• Changes in Blood Cell Counts: Pexidartinib can affect blood cell counts, leading to changes in white blood cells, red blood cells, and platelets.
• Headache: Some patients may experience headaches.
• Dizziness: Dizziness or feeling lightheaded may occur.
• Musculoskeletal Pain: Pain in the muscles or joints may be a side effect.

It’s important to contact your healthcare provider if you experience any side effects, especially if they are severe, persistent, or concerning. Additionally, seek medical attention immediately if you experience signs of a severe allergic reaction, such as difficulty breathing, swelling of the face or throat, or severe rash.

Patients should also be aware of any potential drug interactions with other medications they are taking and report any new or unusual symptoms to their healthcare provider. Your healthcare provider can provide guidance on managing side effects and determine if any adjustments to your treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Follow the storage instructions provided by your healthcare provider or pharmacist. Typically, medications like Pexidartinib are stored at room temperature, away from excessive heat and moisture. Keep it in its original packaging and out of reach of children.
• Disposal: Dispose of Pexidartinib according to local regulations or guidelines. Do not flush medications down the toilet unless instructed to do so. Your pharmacist or healthcare provider can provide guidance on proper disposal methods.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek immediate medical attention. Contact your local poison control center or emergency room. Symptoms of overdose may include severe nausea, vomiting, dizziness, or loss of consciousness.

What other information should I know?

• Regular Follow-ups: Attend scheduled follow-up appointments with your healthcare provider. They will monitor your response to Pexidartinib, assess for any potential side effects, and adjust your treatment plan as needed.
• Lab Tests: Your healthcare provider may order regular blood tests, including liver function tests, to monitor for any changes while you are taking Pexidartinib.
• Inform Healthcare Providers: Keep your healthcare providers informed about all medications, supplements, and herbal products you are taking. This includes over-the-counter medications.
• Pregnancy/Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The safety of Pexidartinib during pregnancy and breastfeeding is not well-established.
• Drug Interactions: Be aware of potential drug interactions. Inform your healthcare provider of any changes in your medication regimen.
• Allergies: Inform your healthcare provider of any known allergies, especially if you have had an allergic reaction to Pexidartinib or similar medications in the past.
• Driving and Activities: Pexidartinib may cause dizziness. Avoid driving or engaging in activities that require alertness until you know how the medication affects you.

Always follow your healthcare provider’s instructions and refer to the specific guidance provided with your prescription. If you have any concerns or questions, contact your healthcare provider for clarification.