WARNING

Permitil is a brand name for a medication that contains fluphenazine, which belongs to the class of antipsychotic drugs. It is primarily used to treat conditions such as schizophrenia and other psychotic disorders. However, like any medication, Permitil comes with potential risks and side effects. Here’s a brief overview:

• Extrapyramidal Symptoms (EPS): Permitil can cause extrapyramidal symptoms, which are movement disorders characterized by symptoms such as tremors, rigidity, and bradykinesia (slowness of movement).
• Tardive Dyskinesia (TD): Long-term use of antipsychotic medications, including Permitil, may lead to tardive dyskinesia, a condition characterized by involuntary and repetitive movements of the face and body.
• Neuroleptic Malignant Syndrome (NMS): This is a rare but serious side effect associated with antipsychotic medications. NMS is characterized by symptoms such as hyperthermia, muscle rigidity, altered mental status, and autonomic dysfunction.
• Sedation and Drowsiness: Permitil can cause sedation and drowsiness, which may impair a person’s ability to concentrate or operate machinery.
• Orthostatic Hypotension: This medication may cause a drop in blood pressure upon standing, leading to dizziness or fainting.
• Anticholinergic Effects: Permitil can have anticholinergic effects, resulting in dry mouth, blurred vision, constipation, and urinary retention.
• Metabolic Effects: Some antipsychotic medications are associated with metabolic changes, including weight gain, increased cholesterol levels, and an increased risk of diabetes.
• Hematologic Effects: Permitil may rarely cause changes in blood cell counts, which can lead to conditions such as agranulocytosis.

It’s crucial for individuals taking Permitil or any antipsychotic medication to be closely monitored by healthcare professionals. They should be aware of potential side effects and report any unusual symptoms promptly. This information is a general overview, and specific risks may vary from person to person. It’s important to consult with a healthcare provider for personalized advice based on individual health conditions.

Why is this medication prescribed?

Permitil (fluphenazine) is an antipsychotic medication used to treat certain mental/mood disorders, such as schizophrenia. It belongs to a class of drugs known as phenothiazines and works by affecting the balance of certain natural substances (neurotransmitters) in the brain.

How should this medicine be used?

Here are some general guidelines for the use of Permitil, but it’s essential to follow the specific instructions provided by your healthcare provider:

• Dosage: The dosage is typically started at a low level and gradually increased under the supervision of a healthcare professional until an effective dose is reached.
• Administration: Permitil is usually taken by mouth with or without food. The medication may be taken once or multiple times a day, as directed by the healthcare provider.
• Consistency: It is important to take Permitil regularly and at the same time each day to maintain a consistent level of the medication in the bloodstream.
• Follow Healthcare Provider’s Instructions: Always follow the dosage and administration instructions provided by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your healthcare professional, as abrupt discontinuation can lead to withdrawal symptoms or a relapse of symptoms.
• Monitoring: Regular follow-up appointments with the healthcare provider are necessary to monitor the effectiveness of the medication and to assess for any side effects or adverse reactions.

It’s important to note that Permitil, like any medication, can have potential side effects and interactions with other drugs. Only a qualified healthcare professional can determine if Permitil is the right medication for a specific individual, considering their medical history and overall health.

If you or someone you know is prescribed Permitil or any other medication, it’s crucial to have open communication with the healthcare provider, ask questions, and report any concerns or side effects promptly. Always seek professional medical advice for personalized information and guidance.

Other uses for this medicine

While Permitil is primarily prescribed for schizophrenia and related disorders, healthcare providers may sometimes prescribe it for other off-label uses. Off-label use refers to the use of a medication for a purpose not approved by regulatory authorities. Examples of off-label uses for Permitil may include certain mood disorders or behavioral issues, but these decisions are made by healthcare professionals based on their clinical judgment.

What special precautions should I follow?

When taking Permitil or any medication, it’s important to follow specific precautions to ensure safety and effectiveness. Here are some special precautions associated with Permitil:

• Medical History: Before starting Permitil, inform your healthcare provider about your complete medical history, including any allergies, liver or kidney problems, cardiovascular issues, seizures, or a history of blood disorders.
• Pregnancy and Breastfeeding: Permitil may have risks during pregnancy, and its use should be discussed thoroughly with a healthcare provider. The drug may pass into breast milk, so breastfeeding while taking Permitil should be discussed with a healthcare professional.
• Interactions with Other Medications: Permitil can interact with various medications, including other antipsychotics, certain antibiotics, anticonvulsants, and medications that affect heart rhythm. Inform your healthcare provider about all medications, supplements, or herbal products you are taking.
• Neurological Effects: Fluphenazine, like other antipsychotics, may cause drowsiness, dizziness, or blurred vision. Caution is advised when operating machinery or performing tasks requiring mental alertness until the individual’s response to the medication is known.
• Temperature Regulation: Antipsychotic medications, including Permitil, may impair the body’s ability to regulate temperature. Individuals should avoid overheating and dehydration, especially in hot weather.
• Regular Monitoring: Regular monitoring of blood pressure, heart rate, and blood tests may be recommended during treatment to detect and manage potential side effects.
• Tardive Dyskinesia Monitoring: Regular assessments for signs of tardive dyskinesia, a movement disorder, are important, especially with long-term use.
• Withdrawal: Abruptly stopping Permitil can lead to withdrawal symptoms. If discontinuation is necessary, it should be done under the guidance of a healthcare professional with a gradual tapering of the medication.

It’s crucial to discuss any concerns or questions about Permitil with your healthcare provider, and to attend scheduled follow-up appointments for ongoing monitoring and adjustment of treatment as needed. This information is not exhaustive, and individual circumstances may warrant additional precautions or considerations.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Permitil. However, individuals taking antipsychotic medications may be at a higher risk of weight gain and metabolic changes. Therefore, maintaining a healthy and balanced diet, along with regular exercise, is advisable. It’s essential to discuss any significant dietary changes with your healthcare provider.

What should I do if I forget a dose?

If you miss a dose of Permitil, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

If you are unsure about what to do or have concerns about missed doses, contact your healthcare provider or pharmacist for guidance. It’s important to maintain a consistent medication schedule for optimal effectiveness.

What side effects can this medication cause?

Permitil, which contains the active ingredient fluphenazine, is an antipsychotic medication used to treat conditions such as schizophrenia and other psychotic disorders. Like all medications, it can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience effects that are not listed. If you are prescribed Permitil, it’s crucial to be aware of potential side effects and to promptly report any unusual or severe symptoms to your healthcare provider. Here are some common and serious side effects associated with Permitil:

Common Side Effects:

• Extrapyramidal Symptoms (EPS):
  • Tremors
  • Rigidity
  • Akathisia (restlessness)
  • Dystonia (involuntary muscle contractions)
• Sedation and Drowsiness:
  • Feeling sleepy or tired
• Orthostatic Hypotension:
  • Drop in blood pressure upon standing, leading to dizziness or fainting
• Anticholinergic Effects:
  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention
• Metabolic Effects:
  • Weight gain
  • Increased cholesterol levels
  • Increased risk of diabetes

Serious Side Effects:

• Neuroleptic Malignant Syndrome (NMS): A rare but serious condition characterized by hyperthermia, muscle rigidity, altered mental status, and autonomic dysfunction.
• Tardive Dyskinesia (TD): Involuntary, repetitive movements, particularly of the face and tongue. This can be a serious and potentially irreversible side effect associated with long-term use of antipsychotic medications.
• Hematologic Effects: Changes in blood cell counts, which can lead to conditions such as agranulocytosis.
• Cardiovascular Effects: Irregular heartbeats (arrhythmias)
• Seizures: Permitil may lower the seizure threshold, increasing the risk of seizures.
• Hyperprolactinemia: Increased levels of the hormone prolactin, which can lead to menstrual irregularities, breast enlargement (in both males and females), and other reproductive issues.
• Cognitive Effects: Cognitive impairment or confusion, particularly in older adults.
• Allergic Reactions:
  • Rash
  • Itching
  • Swelling
  • Severe dizziness
  • Difficulty breathing

It’s important to attend regular follow-up appointments with your healthcare provider for monitoring and to discuss any side effects or concerns you may have. If you experience severe or concerning side effects, seek medical attention promptly. Do not stop taking Permitil without consulting your healthcare provider, as abrupt discontinuation can lead to withdrawal symptoms or a relapse of symptoms.

What should I know about storage and disposal of this medication?

Storage and Disposal of Permitil:

• Storage:
  • Store Permitil at room temperature, away from light and moisture.
  • Keep it out of reach of children and pets.
  • Do not store Permitil in the bathroom, where it may be exposed to moisture.
• Disposal:
  • Dispose of unused or expired medication in accordance with local regulations and guidelines.
  • Do not flush medications down the toilet unless specifically instructed to do so.
  • Check with your pharmacist or local waste disposal facility for proper disposal instructions.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects, seek emergency medical attention or contact your local poison control center immediately. Overdose symptoms may include extreme drowsiness, severe dizziness, fainting, or difficulty breathing.

What other information should I know?

• Regular Monitoring: Attend regular follow-up appointments with your healthcare provider to monitor the effectiveness of the medication and assess for any potential side effects.
• Blood Tests: Your healthcare provider may perform regular blood tests to monitor for changes in blood cell counts and metabolic parameters.
• Cautions for Driving and Operating Machinery: Be cautious about activities requiring mental alertness, as Permitil may cause drowsiness, dizziness, or blurred vision.
• Avoid Alcohol and CNS Depressants: Limit or avoid alcohol while taking Permitil, as it may enhance the sedative effects of the medication. Exercise caution when using other central nervous system (CNS) depressants, such as certain medications or substances, as they may interact with Permitil.
• Inform Healthcare Providers: Inform all healthcare providers, including dentists and emergency medical personnel, about your use of Permitil. This includes over-the-counter medications and herbal supplements.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Permitil with your healthcare provider.
• Potential Withdrawal Symptoms: Do not abruptly stop taking Permitil, as it can lead to withdrawal symptoms or a relapse of symptoms. If discontinuation is necessary, it should be done under the guidance of a healthcare professional with a gradual tapering of the medication.
• Patient Education: Educate yourself about the medication, its purpose, potential side effects, and the importance of adherence to the prescribed treatment plan.

Always follow the specific instructions provided by your healthcare provider and pharmacist. If you have any questions or concerns about Permitil or its use, don’t hesitate to reach out to your healthcare team for clarification and guidance.