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Orenitram (Generic Treprostinil)

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Why is this medication prescribed?

Orenitram (generic name: treprostinil) is a medication that is prescribed for the treatment of pulmonary arterial hypertension (PAH). PAH is a condition characterized by high blood pressure in the arteries of the lungs, which can lead to various symptoms such as shortness of breath, fatigue, chest pain, and difficulty exercising. Orenitram belongs to a class of medications called prostacyclin analogs, which help to dilate the blood vessels and improve blood flow in the lungs.

Orenitram is typically prescribed to adults with PAH who are classified as World Health Organization (WHO) functional class II-III. It is used to improve exercise capacity and delay disease progression. It is not a cure for PAH, but it can help manage the symptoms and improve quality of life.

How should this medicine be used?

Orenitram (treprostinil) is available as extended-release tablets or as an extended-release oral suspension. The specific dosing and administration instructions for Orenitram should be provided by a healthcare professional, as they can vary depending on the individual’s specific needs and the severity of their pulmonary arterial hypertension (PAH). It’s important to follow the instructions provided by your doctor or pharmacist. However, here are some general guidelines:

  • Orenitram tablets should be taken with food to help minimize stomach-related side effects. The tablets should be swallowed whole and not crushed or chewed.
  • Orenitram oral suspension should be mixed with water using the provided dosing syringe or oral dispenser. Follow the instructions on how to measure the correct dose. Shake the suspension well before each use and discard any unused portion after 60 days.
  • The starting dosage and subsequent adjustments will be determined by your doctor based on your individual needs. They will consider factors such as your body weight, tolerability, and response to the medication.
  • Orenitram is usually taken multiple times per day. The frequency and timing of doses will be determined by your doctor. It’s important to adhere to the prescribed schedule and not miss any doses.
  • Regular follow-up visits with your doctor are essential to monitor the effectiveness of the medication and make any necessary adjustments to the dosage.
  • Do not make any changes to your dosage or stop taking Orenitram without consulting your healthcare professional.

It’s important to note that these are general guidelines, and individual dosing instructions may differ. Always consult your doctor or pharmacist for specific instructions on how to use Orenitram properly. They will provide you with detailed information and answer any questions you may have.

Other uses for this medicine

While Orenitram is primarily used for PAH, there are no known other approved uses for this medication. It’s important to consult with a healthcare professional or refer to the latest prescribing information to obtain the most up-to-date and accurate information on the approved uses of Orenitram.

What special precautions should I follow?

Regarding special precautions, it’s crucial to follow your healthcare provider’s instructions and consider the following:

  • Allergies: Inform your doctor if you have any known allergies, particularly to treprostinil or any other prostacyclin analogs.
  • Medical history: Provide your healthcare provider with a comprehensive medical history, especially if you have liver problems, bleeding disorders, low blood pressure, or any other significant medical conditions.
  • Pregnancy and breastfeeding: Notify your doctor if you are pregnant or planning to become pregnant, as Orenitram may pose risks to the unborn baby. Additionally, it is not known whether treprostinil passes into breast milk, so discuss the potential risks and benefits with your doctor if you are breastfeeding or planning to breastfeed.
  • Drug interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking, as certain drugs may interact with Orenitram and affect its effectiveness or increase the risk of side effects.
  • Side effects: Be aware of the potential side effects associated with Orenitram, which may include headache, nausea, vomiting, diarrhea, jaw pain, flushing, and others. Consult your doctor if you experience any bothersome or severe side effects.

It’s important to note that this information may not be comprehensive or up to date, and it’s always best to consult a healthcare professional or refer to the prescribing information and medication guide provided with the medication for specific instructions and precautions related to Orenitram.

What special dietary instructions should I follow?

When taking Orenitram, it’s important to follow your healthcare provider’s instructions regarding dietary guidelines. There are no specific dietary restrictions associated with Orenitram. Generally, it is recommended to maintain a balanced and healthy diet while taking this medication. Nevertheless, it’s always advisable to consult with your healthcare provider or refer to the medication guide for any specific dietary instructions related to Orenitram, as there may be updates or individual considerations that apply.

What should I do if I forget a dose?

If you forget to take a dose of Orenitram, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for the missed one. If you have any concerns or questions about missed doses or your dosing schedule, it’s best to reach out to your healthcare provider for guidance.

What side effects can this medication cause?

Orenitram (treprostinil) may cause side effects in some individuals. The following list includes some common and potentially serious side effects associated with Orenitram, although not all individuals will experience these effects:

Common side effects of Orenitram may include:

  • Headache
  • Diarrhea
  • Nausea
  • Vomiting
  • Flushing (redness and warmth of the skin)
  • Jaw pain
  • Decreased appetite
  • Abdominal pain
  • Peripheral edema (swelling in the hands, feet, or ankles)
  • Dizziness
  • Insomnia (difficulty sleeping)
  • Pain in extremities
  • Rash
  • Back pain
  • Muscle cramps

It’s important to note that these are not all the possible side effects of Orenitram. Some individuals may experience other side effects, and there is also a potential for more serious adverse reactions. If you experience any severe or persistent side effects or any signs of an allergic reaction (such as rash, itching, swelling, severe dizziness, or difficulty breathing), it is crucial to seek immediate medical attention.

Remember to consult your healthcare provider or refer to the medication guide for a comprehensive list of possible side effects associated with Orenitram. They will be able to provide you with more detailed information and guidance based on your specific situation.

What should I know about storage and disposal of this medication?


  • Orenitram should be stored at room temperature, away from excessive heat and moisture.
  • Keep the medication in its original container, tightly closed, and out of reach of children and pets.
  • Do not use Orenitram after the expiration date printed on the container or packaging.

Disposal of unused or expired medication:

  • It is important to properly dispose of any unused or expired Orenitram.
  • Follow local regulations or guidelines for medication disposal in your area.
  • Do not dispose of Orenitram by flushing it down the toilet or pouring it down the drain unless instructed to do so by the appropriate authorities.

In case of emergency/overdose

  • If you suspect an overdose or have any severe or life-threatening symptoms, call emergency services or go to the nearest emergency room immediately.
  • Contact your local poison control center or healthcare provider for further guidance on how to manage an overdose of Orenitram.

What other information should I know?

  • Regularly refill your prescription in a timely manner to avoid running out of medication.
  • Attend all scheduled appointments with your healthcare provider to monitor your progress and discuss any concerns or potential adjustments to your treatment plan.
  • Inform all healthcare professionals involved in your care, including dentists and surgeons, that you are taking Orenitram.
  • Carry an identification card or wear a medical alert bracelet indicating that you are taking Orenitram.
  • Do not change your dosage or stop taking Orenitram without consulting your healthcare provider, as it may affect the effectiveness of your treatment.

It’s important to note that this information may not be exhaustive, and it’s always best to consult with your healthcare provider or refer to the medication guide and prescribing information provided with Orenitram for the most accurate and up-to-date instructions and recommendations specific to your situation.

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