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Orapred (Generic Prednisolone)

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Why is this medication prescribed?

Orapred, which contains the active ingredient prednisolone sodium phosphate, is prescribed for several reasons. The medication is a type of corticosteroid, specifically a glucocorticoid, and it has anti-inflammatory and immunosuppressant properties. Here are some common reasons why Orapred may be prescribed:

  • Inflammatory Conditions: Orapred is often prescribed to reduce inflammation in various parts of the body. It can be used to manage inflammatory conditions such as asthma, rheumatoid arthritis, inflammatory bowel disease (Crohn’s disease, ulcerative colitis), and certain dermatological conditions (eczema, psoriasis).
  • Allergic Reactions: Orapred may be prescribed to treat severe allergic reactions, such as anaphylaxis or angioedema, by reducing inflammation and suppressing the immune response.
  • Asthma: Orapred is sometimes used to manage acute asthma exacerbations or to control persistent asthma symptoms in individuals who do not respond well to other asthma medications.
  • Autoimmune Disorders: Orapred can be prescribed for certain autoimmune disorders where the immune system mistakenly attacks healthy tissues, such as systemic lupus erythematosus (lupus) or autoimmune hepatitis.
  • Organ Transplants: After organ transplantation, Orapred may be prescribed to prevent organ rejection. It helps suppress the immune system to reduce the risk of the body rejecting the transplanted organ.
  • Other Conditions: Orapred may be used for other medical conditions where inflammation or immune suppression is necessary, as determined by a healthcare professional.

It’s important to note that Orapred should be used only as prescribed by a healthcare provider, as it can have potential side effects and requires careful monitoring. The specific dosage and duration of treatment will depend on the individual’s condition and response to the medication.

How should this medicine be used?

Orapred should be used exactly as prescribed by your healthcare provider. The medication is available in oral solution form and comes with specific dosing instructions. Here are some general guidelines for using Orapred:

  • Follow the Prescribed Dosage: Take Orapred according to the prescribed dosage provided by your healthcare provider. The dosage may vary depending on your condition, age, and weight.
  • Measure the Dose: Use the oral dosing syringe or measuring device provided with the medication to accurately measure the prescribed dose. Do not use household teaspoons or tablespoons, as they may not provide the correct dose.
  • Take with or without Food: Orapred can be taken with or without food. However, if you experience stomach upset, taking it with food may help alleviate any discomfort.
  • Shake the Bottle: Before each use, shake the Orapred oral solution bottle well to ensure that the medication is properly mixed.
  • Administer the Oral Solution: Using the provided dosing device, carefully measure the prescribed amount of oral solution. You can take the solution directly by mouth or mix it with a small amount of juice or milk to improve the taste. Swallow the mixture immediately without chewing.
  • Follow the Schedule: Take Orapred as directed by your healthcare provider. It is important to take the medication consistently and at the same time each day to maintain its effectiveness.
  • Do Not Stop Suddenly: Do not abruptly stop taking Orapred without consulting your healthcare provider, as this can lead to withdrawal symptoms or a flare-up of the condition being treated. If you need to discontinue the medication, your healthcare provider will provide instructions for gradually tapering the dose.
  • Follow Up with Healthcare Provider: Regularly follow up with your healthcare provider while taking Orapred to monitor your response to the medication and any potential side effects. They may need to adjust the dosage or duration of treatment based on your progress.

Always consult your healthcare provider or pharmacist if you have any specific questions or concerns about using Orapred. They will provide you with personalized instructions based on your condition and medical history.

Other uses for this medicine

However, it is important to note that off-label use should be discussed and prescribed by a healthcare professional. Some potential off-label uses may include:

  • Allergic Reactions: Orapred can be used to manage severe allergic reactions or anaphylaxis when other treatments are not available or appropriate.
  • Asthma: In certain cases, Orapred may be prescribed to manage severe or uncontrolled asthma that is not responding adequately to other medications.
  • Rheumatic Diseases: Orapred can be used to treat various rheumatic conditions, such as rheumatoid arthritis or lupus, to help reduce inflammation and control symptoms.
  • Dermatological Conditions: It may be used for certain skin conditions, including severe allergic reactions, eczema, or psoriasis, to help alleviate inflammation and symptoms.
  • Respiratory Conditions: Orapred may be used to manage respiratory conditions like chronic obstructive pulmonary disease (COPD) or bronchitis in specific situations.

Remember, the information provided here is for general knowledge and should not replace the advice of a healthcare professional. Always consult your doctor or pharmacist for personalized instructions and recommendations regarding the use of Orapred.

What special precautions should I follow?

Regarding special precautions, there are several important considerations to keep in mind when using Orapred:

  • Allergies: Inform your healthcare provider if you have any known allergies to prednisolone or other corticosteroids.
  • Medical History: Provide your healthcare provider with a comprehensive medical history, including any previous or existing medical conditions, infections, or mental health issues.
  • Interactions: Inform your healthcare provider about any other medications, supplements, or herbal products you are currently taking, as they may interact with Orapred and affect its effectiveness or increase the risk of side effects.
  • Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of using Orapred with your healthcare provider.
  • Immunosuppression: Orapred suppresses the immune system, making you more susceptible to infections. Avoid close contact with individuals who have contagious illnesses, such as chickenpox or measles, while taking this medication.
  • Long-term Use: Prolonged use of Orapred may require careful monitoring, as it can lead to side effects such as adrenal suppression, osteoporosis, and increased risk of infections. Regular follow-up with your healthcare provider is important in such cases.

It is crucial to adhere to your healthcare provider’s instructions, dosage, and schedule while taking Orapred and to report any concerning side effects or changes in your health. They can provide personalized guidance and monitor your response to the medication.

What special dietary instructions should I follow?

Regarding dietary instructions, there are no specific dietary restrictions associated with Orapred. However, it is generally recommended to follow a healthy, balanced diet. If you have any specific dietary concerns or restrictions due to other medical conditions, it is advisable to discuss them with your doctor or a registered dietitian. They can provide personalized guidance based on your individual needs.

What should I do if I forget a dose?

Regarding a missed dose of Orapred:

  • If you forget to take a dose, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule.
  • Do not double the dose to make up for a missed one. Taking a double dose can increase the risk of side effects.
  • If you are unsure about what to do or if you have missed multiple doses, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Orapred, like other corticosteroids, can potentially cause side effects. The likelihood and severity of these side effects can vary depending on factors such as the dosage, duration of treatment, and individual susceptibility. It’s important to note that not everyone who takes Orapred will experience side effects, and some individuals may experience different side effects than others. Here are some possible side effects associated with Orapred:

  1. Common side effects:
    • Increased appetite
    • Weight gain
    • Fluid retention and swelling (edema)
    • Mood changes (irritability, mood swings)
    • Difficulty sleeping (insomnia)
    • Increased blood sugar levels (hyperglycemia)
    • Increased risk of infections
    • Gastric irritation or ulcers
    • Acne or skin changes
    • Delayed wound healing
  2. Less common side effects:
    • Adrenal suppression: Long-term use of Orapred may suppress the natural production of cortisol by the adrenal glands, which can lead to adrenal insufficiency when the medication is discontinued.
    • Osteoporosis: Prolonged use of Orapred can increase the risk of bone loss and osteoporosis, leading to an increased susceptibility to fractures.
    • Cataracts and glaucoma: Long-term use or high doses of corticosteroids like Orapred can increase the risk of developing cataracts or glaucoma.
    • Increased blood pressure: Orapred can cause elevated blood pressure in some individuals.
    • Skin thinning and easy bruising: Prolonged use of Orapred can lead to thinning of the skin and increased susceptibility to bruising.
    • Suppressed immune system: Orapred reduces immune system activity, which can increase the risk of infections and impair the body’s ability to fight off illnesses.

It’s important to promptly report any unusual or severe side effects to your healthcare provider. They can evaluate your individual situation and make adjustments to the medication or provide additional guidance to manage the side effects. Additionally, following the prescribed dosage and regularly monitoring your health while on Orapred can help minimize the potential risks and side effects.

What should I know about storage and disposal of this medication?


  • Follow the storage instructions provided on the medication packaging or as advised by your pharmacist or healthcare provider.
  • Store Orapred at room temperature, away from excessive heat, moisture, and direct light.
  • Keep the medication out of reach of children and pets to prevent accidental ingestion.


  • Dispose of unused or expired Orapred properly and safely.
  • Follow any specific disposal instructions provided by your local regulations or healthcare provider.
  • Do not flush the medication down the toilet or pour it into drains unless instructed to do so.
  • Consult your pharmacist or local waste management authority for guidance on safe disposal methods, such as medication take-back programs or designated collection sites.

In case of emergency/overdose

  • In case of an emergency or suspected overdose, immediately contact your local emergency services or go to the nearest emergency room.
  • Inform the medical professionals about the medication you have taken, including the name (Orapred) and the dosage.

What other information should I know?

  • Regularly attend follow-up appointments with your healthcare provider to monitor your response to Orapred and address any concerns or questions.
  • Inform all healthcare professionals involved in your care about your use of Orapred, including dentists, surgeons, or specialists, as the medication may have implications for certain procedures or treatments.
  • Carry a medical identification card or wear a medical bracelet indicating that you are taking Orapred or other corticosteroids. This can be helpful in case of emergencies.
  • Inform your healthcare provider if you experience any new symptoms, changes in mood or behavior, or any unusual side effects while taking Orapred.
  • Be cautious about interactions with other medications, including over-the-counter drugs and supplements. Always inform your healthcare provider about all the medications you are taking to avoid potential interactions.

It’s essential to consult your healthcare provider or pharmacist for specific instructions and advice on storage, disposal, and actions to take in case of emergencies or overdoses based on your individual circumstances and the prescribed medication.

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