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Ofev (Generic Nintedanib )

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Why is this medication prescribed?

Ofev (generic name: nintedanib) is a prescription medication used in the treatment of certain lung diseases, particularly idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD).

IPF is a progressive and chronic lung disease characterized by the formation of scar tissue in the lungs, leading to a decline in lung function and difficulty breathing. SSc-ILD is a similar condition that occurs in individuals with systemic sclerosis, a connective tissue disease.

Ofev works by inhibiting specific proteins called tyrosine kinases that are involved in the development of fibrosis, the excessive scarring of tissue. By blocking these proteins, Ofev helps slow down the progression of fibrosis and can help preserve lung function.

How should this medicine be used?

When prescribed Ofev, it is essential to follow the instructions provided by your healthcare professional. Typically, Ofev is taken orally as a capsule. The usual recommended dosage is one capsule (150 mg) twice daily, taken approximately 12 hours apart.

To minimize the potential for gastrointestinal side effects, such as diarrhea, it is generally advised to take Ofev with food. Swallow the capsule whole with water, and do not crush or chew it.

It’s important to note that individual dosages and treatment plans may vary based on the specific lung disease being treated, as well as other factors determined by your healthcare provider. Therefore, always consult with your doctor or healthcare professional for personalized instructions on how to use Ofev. They will provide you with the most accurate and up-to-date information for your condition.

Other uses for this medicine

Ofev (nintedanib) is primarily approved for the treatment of idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD). These are the main indications for which Ofev is prescribed and supported by clinical evidence.

It’s worth noting that Ofev is not approved for other lung diseases or conditions. While there may be ongoing research or off-label use of Ofev in certain cases, it is crucial to follow the approved indications as determined by your healthcare provider.

What special precautions should I follow?

Regarding special precautions, it’s important to consider the following:

  • Pre-existing medical conditions: Inform your healthcare provider about any pre-existing medical conditions you have, such as liver problems, kidney problems, or cardiovascular diseases, as these may affect the use of Ofev.
  • Bleeding risk: Ofev may increase the risk of bleeding. If you have a history of bleeding disorders or are taking medications that increase the risk of bleeding, inform your healthcare provider.
  • Pregnancy and breastfeeding: Ofev can cause harm to unborn babies, so it is not recommended during pregnancy. It is also not known whether Ofev passes into breast milk, so breastfeeding should be avoided while taking this medication.
  • Drug interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Ofev may interact with certain drugs, potentially affecting their effectiveness or causing adverse effects.
  • Side effects: Ofev may cause various side effects, including diarrhea, nausea, vomiting, decreased appetite, weight loss, abdominal pain, liver enzyme elevation, and others. Report any persistent or severe side effects to your healthcare provider.
  • Regular monitoring: Your healthcare provider may order periodic tests, including liver function tests and blood tests, to monitor your response to Ofev and check for any potential side effects.

Remember, these are general precautions, and it is essential to consult with your healthcare provider for personalized advice based on your specific medical history and condition. They will provide you with the most accurate and up-to-date information regarding the use of Ofev and any precautions specific to your case.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with taking Ofev (nintedanib). However, it is generally recommended to take Ofev with food to minimize the potential for gastrointestinal side effects, such as diarrhea. Taking Ofev with a meal or snack can help reduce the likelihood of experiencing stomach-related issues. If you have any specific dietary concerns or restrictions, it’s best to consult with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

If you forget to take a dose of Ofev, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It’s important to adhere to the prescribed dosing schedule as closely as possible to maintain the effectiveness of the medication. If you have any concerns or questions about missed doses, it’s advisable to consult with your healthcare provider for guidance.

What side effects can this medication cause?

Ofev (nintedanib) can cause various side effects. Not everyone who takes Ofev will experience these side effects, and their severity can vary from person to person. Some common side effects of Ofev include:

  • Gastrointestinal issues: The most commonly reported side effect of Ofev is diarrhea. Other gastrointestinal side effects may include nausea, vomiting, decreased appetite, indigestion, abdominal pain, and weight loss.
  • Liver problems: Ofev can cause liver enzyme elevation, which may be a sign of liver damage. Symptoms can include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, and unusual tiredness. Regular monitoring of liver function is typically recommended while taking Ofev.
  • Cardiovascular effects: Ofev has been associated with an increased risk of bleeding, including bleeding in the lungs, gastrointestinal tract, and other parts of the body. It may also cause an increased heart rate (tachycardia).
  • Respiratory issues: Some individuals may experience shortness of breath or difficulty breathing while taking Ofev. If you notice any worsening of respiratory symptoms, it’s important to inform your healthcare provider.
  • Dermatological reactions: Ofev can cause skin reactions such as rash, itching, and dermatitis.
  • Musculoskeletal effects: Muscle pain and joint pain are known side effects of Ofev.

It’s important to note that this is not an exhaustive list of side effects, and others may occur. If you experience any persistent or severe side effects while taking Ofev, it is crucial to contact your healthcare provider for further evaluation and guidance.

Additionally, it’s worth mentioning that some side effects of Ofev may require immediate medical attention. If you experience symptoms of a severe allergic reaction, such as difficulty breathing, hives, swelling of the face, lips, tongue, or throat, seek immediate medical assistance.

Always consult with your healthcare provider for a comprehensive understanding of the potential side effects associated with Ofev and how to manage them effectively. They can provide personalized guidance based on your medical history and individual circumstances.

What should I know about storage and disposal of this medication?


  • Ofev should be stored at room temperature, typically between 68°F to 77°F (20°C to 25°C).
  • Keep the medication in its original container and away from excessive heat, moisture, and direct light.
  • Store Ofev out of reach of children and pets.
  • Do not use Ofev beyond its expiration date. Check the packaging for the expiry date and discard any expired medication.

Disposal of unused Ofev:

  • It is important to dispose of unused or expired Ofev properly.
  • Follow any specific disposal instructions provided by your healthcare provider or local regulations.
  • If no specific instructions are provided, it is generally recommended to contact your local pharmacy or healthcare facility to inquire about proper medication disposal options. They can provide guidance on how to safely dispose of Ofev in an environmentally responsible manner.

In case of emergency/overdose

  • If you believe you or someone else has taken an overdose of Ofev, or if you experience severe symptoms or a life-threatening situation, immediately contact emergency services or your local poison control center.
  • It may also be helpful to have the original packaging or container with you to provide information about the medication.

What other information should I know?

  • Regular follow-up appointments with your healthcare provider are typically recommended to monitor your response to Ofev, evaluate any potential side effects, and make any necessary dosage adjustments.
  • Inform all healthcare providers involved in your care, including dentists and surgeons, that you are taking Ofev. They should be aware of your medication use before any medical or dental procedures.
  • Keep a list of all medications, including Ofev, that you are currently taking. This list can be helpful to provide to healthcare professionals when necessary.
  • Attend all scheduled laboratory tests and monitoring appointments as advised by your healthcare provider.
  • If you have any questions or concerns about Ofev or your treatment plan, do not hesitate to reach out to your healthcare provider for clarification and guidance.

Always consult your healthcare provider or pharmacist for the most up-to-date and accurate information regarding the storage, disposal, emergencies, and other aspects related to Ofev. They can provide specific instructions and address any concerns you may have.

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